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    REDUCING SIGNAL DISTORTIONS
    4.
    发明申请
    REDUCING SIGNAL DISTORTIONS 审中-公开
    减少信号失常

    公开(公告)号：US20110031988A1

    公开(公告)日：2011-02-10

    申请号：US12697712

    申请日：2010-02-01

    申请人： Lindy Jane Murphy ,  Hugh Allen Oliver Hill

    发明人： Lindy Jane Murphy ,  Hugh Allen Oliver Hill

    IPC分类号： G01R27/08

    CPC分类号： C12Q1/001

    摘要： The invention relates to reducing signal distortions occurring when a potential is applied to an electrochemical cell. Electrochemical measurements are obtained in the presence of a specific chemical entity which is an aminoglycoside, an organic polyamine and/or a substance capable of raising the ionic strength of the sample.

    摘要翻译： 本发明涉及减少当将电位施加到电化学电池时发生的信号失真。 在特定化学实体存在下获得电化学测量，所述特定化学实体是氨基糖苷，有机多胺和/或能够提高样品的离子强度的物质。

    Oxidation by Hydrogen Peroxide
    6.
    发明申请
    Oxidation by Hydrogen Peroxide 审中-公开
    过氧化氢氧化

    公开(公告)号：US20080044882A1

    公开(公告)日：2008-02-21

    申请号：US10590426

    申请日：2005-02-23

    申请人： Hugh Allen Oliver Hill ,  Luet Lok Wong ,  Barry Dean Fleming

    发明人： Hugh Allen Oliver Hill ,  Luet Lok Wong ,  Barry Dean Fleming

    IPC分类号： C12N9/08 ,  C12N9/04

    CPC分类号： C12P7/00

    摘要： The present invention provides a method of carrying out an oxidation reaction catalysed by a monooxygenase enzyme and using hydrogen peroxide as an oxidant, in which reaction a low level of oxidation damage of the monooxygenase occurs, said method comprising producing the hydrogen peroxide simultaneously with the oxidation reaction, wherein the hydrogen peroxide is produced at a rate less than or equal to the rate at which it is used in the reaction or said method comprising carrying out the reaction in the presence of an H2O2 or hydroxyl radical sequestering agent that controls the H2O2 or hydroxyl radical concentration.

    摘要翻译： 本发明提供一种进行由单加氧酶催化的氧化反应并使用过氧化氢作为氧化剂的方法，其中发生单加氧酶的低水平的氧化损伤，所述方法包括与氧化物同时生产过氧化氢 反应，其中所述过氧化氢的产生速率小于或等于其在反应中使用的速率或所述方法，包括在H 2 O 2存在下进行反应， 或者羟基自由基螯合剂，其控制H 2 O 2 O 2或羟基自由基浓度。

    Method for the selection and identification of peptide or protein molecules by means of phage display
    8.
    发明申请
    Method for the selection and identification of peptide or protein molecules by means of phage display 审中-公开
    通过噬菌体展示法选择和鉴定肽或蛋白质分子的方法

    公开(公告)号：US20050014135A1

    公开(公告)日：2005-01-20

    申请号：US10855668

    申请日：2004-05-27

    申请人： Oliver Hill ,  Holger Ottleben ,  Stefan Dickopf ,  Klaus Burkert

    发明人： Oliver Hill ,  Holger Ottleben ,  Stefan Dickopf ,  Klaus Burkert

    IPC分类号： B01L3/00 ,  G01N21/55 ,  C12Q1/70

    CPC分类号： G01N21/553 ,  B01L3/5085 ,  B82Y30/00

    摘要： The invention relates to a method for the selection and identification of at least on representative (interaction partner) from a plurality of peptide or protein molecules, which can specifically interact with at least one representative from a plurality of target molecules, forming a bond. The inventive method comprises the following steps: (a) a virus system consisting of a plurality of viruses, wherein each virus respectively presents at least on representative from the plurality of peptide or protein molecules on the surface thereof, is brought into contact with the plurality of target molecules (ligands) which are immobilized on the surface of a solid phase carrier such that they are position addressable in a two-dimensional grade; (b) unbound viruses removed from the surface thereof; and (c) the interaction partner is identified by detection and determination of the position of the bond between the immobilized ligand and the interaction partner presented by the virus with the aid of a marker-free detection method. The described method makes it possible to concentrate viruses presenting interaction partners by means of an optionally cyclic repetition of selection. Optionally, selected interaction partners are recombinantly expressed after identification of the coding nucleotide sequence.

    摘要翻译： 本发明涉及一种用于从多个肽或蛋白质分子中选择和鉴定至少一个代表性（相互作用配偶体）的方法，其可与多个靶分子的至少一个代表特异性相互作用，形成键。 本发明的方法包括以下步骤：（a）由多种病毒组成的病毒系统，其中每个病毒分别至少表现出其表面上的多个肽或蛋白质分子的代表，与多个病毒接触 的固定在固相载体的表面上的靶分子（配体），使得它们位于二维等级的位置; （b）从其表面去除未结合的病毒; 和（c）通过利用无标记检测方法的检测和确定固定的配体与病毒所呈现的相互作用配偶之间的键的位置来鉴定相互作用配偶体。 所描述的方法使得可以通过可选地循环重复的选择来浓缩呈现相互作用伴侣的病毒。 任选地，在识别编码核苷酸序列后重组表达所选择的相互作用伴侣。

    Method of producing phosphoric acid from high iron and aluminum content phosphate rocks using nitric acid
    9.
    发明授权
    Method of producing phosphoric acid from high iron and aluminum content phosphate rocks using nitric acid 失效
    使用硝酸从高铁和铝含量磷酸盐岩生产磷酸的方法

    公开(公告)号：US4039624A

    公开(公告)日：1977-08-02

    申请号：US596777

    申请日：1975-07-17

    申请人： Robert Oliver Hill

    发明人： Robert Oliver Hill

    IPC分类号： C01B25/22 ,  C01B25/234 ,  C05B11/06 ,  C01B25/16

    CPC分类号： C05B11/06 ,  C01B25/22 ,  C01B25/234

    摘要： This invention concerns the solubilization of phosphate values in phosphate bearing rock which contains high contents of aluminium and/or iron by attacking the phosphate rock with a nitric acid leach solution for a time suitable to produce a phosphate rich leach solution containing no more than 10 parts Fe and Al in solution calculated as R.sub.2 O.sub.3 per 100 parts of P.sub.2 O.sub.5 in solution.

    摘要翻译： 本发明涉及通过用硝酸浸出溶液攻击磷酸盐岩，适当地生产含有不超过10份的富含磷酸盐的浸出溶液的时间，使磷酸盐值溶解在含磷酸盐岩的含磷岩石中 Fe和Al在溶液中按每100份P 2 O 5计算为R2O3。