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1.
公开(公告)号:US3959314A
公开(公告)日:1976-05-25
申请号:US442401
申请日:1974-02-14
IPC分类号: C07C67/00 , C07C239/00 , C07C251/34 , C07C251/48 , C07D307/54 , C07D333/24
CPC分类号: C07D333/24 , C07D307/54
摘要: 2-Aryl-2-hydroxyiminoacetic acids rich in the syn isomer are prepared by reaction of an arylglyoxylic acid with hydroxylamine in an aqueous reaction medium, e.g. water, in the presence of a source of magnesium, calcium or zinc ions, e.g. magnesium hydroxide. The acids so obtained are of value as synthetic intermediates in the preparation of penicillin and cephalosporin antibiotics containing syn-2-aryl-2-hydroxyiminoacetamido side chains.
摘要翻译: 富含顺式异构体的2-芳基-2-羟基亚氨基乙酸通过芳基乙醛酸与羟胺在水性反应介质中反应来制备, 在存在镁,钙或锌离子的源的情况下,例如水。 氢氧化镁。 如此获得的酸在制备含有顺式-2-芳基-2-羟基亚氨基乙酰氨基侧链的青霉素和头孢菌素抗生素中具有价值。
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公开(公告)号:US4014869A
公开(公告)日:1977-03-29
申请号:US528944
申请日:1974-12-02
IPC分类号: C07D307/46 , C07D307/54 , C07D333/22 , C07D333/24 , C07D499/00 , C07D499/44 , C07D499/46 , C07D501/20 , C07D501/30 , C07D501/36 , C07D501/42 , C07D501/57
CPC分类号: C07D333/24 , C07D307/46 , C07D307/54 , C07D333/22 , C07D499/00
摘要: Novel antibiotic compounds which are 7.beta.-acrylamidoceph-3-em-4-carboxylic acids, and 6.beta.-acrylamidopenam-3-carboxylic acids and non-toxic derivatives thereof wherein the acrylamido group has the structure ##STR1## wherein A is aryl group and B is a substituted or unsubstituted lower alkyl, lower alkenyl or lower alkynyl group; or an aryl, cycloalkyl or cycloalkenyl group. These compounds possess antibacterial activity against gram-positive and gram-negative organisms coupled with stability to .beta.-lactamases. The invention further relates to the administration of the compounds.
摘要翻译: 作为7β-丙烯酰胺氨基-3-元-4-羧酸的新型抗生素化合物和6种β-丙烯酰胺氨基-3-羧酸及其无毒性衍生物,其中丙烯酰氨基具有结构
,其中A是芳基 和B是取代或未取代的低级烷基,低级烯基或低级炔基; 或芳基,环烷基或环烯基。 这些化合物具有抗革兰氏阳性和革兰氏阴性菌与β-内酰胺酶稳定性的抗菌活性。 本发明还涉及给药化合物。
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