公开(公告)号：US20050118680A1

公开(公告)日：2005-06-02

申请号：US11035998

申请日：2005-01-18

申请人： Haodong Li ,  Steven Ruben ,  Granger Sutton

发明人： Haodong Li ,  Steven Ruben ,  Granger Sutton

IPC分类号： A61K38/00 ,  C07K14/52 ,  C12N15/12 ,  C12N15/19 ,  A61K38/19 ,  C07H21/04 ,  C07K14/705

CPC分类号： C07K14/523 ,  A61K38/00

摘要： A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

摘要翻译： 公开了人趋化多肽，编码它的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了将多肽用于多种目的的方法，包括：干细胞动员，髓过保护，神经元保护，治疗肿瘤，伤口愈合，治疗寄生虫感染和调节造血。 还公开了多肽拮抗剂和用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

公开(公告)号：US6100389A

公开(公告)日：2000-08-08

申请号：US44855

申请日：1998-03-20

申请人： Haodong Li ,  Steven M. Ruben ,  Granger Sutton, III

发明人： Haodong Li ,  Steven M. Ruben ,  Granger Sutton, III

IPC分类号： A61K38/00 ,  C07K14/52 ,  C12N15/12 ,  C12N15/19 ,  C12N1/20 ,  C12N5/10

CPC分类号： C07K14/523 ,  A61K38/00

摘要： A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

摘要翻译： 公开了人趋化多肽，编码它的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了将多肽用于多种目的的方法，包括：干细胞动员，髓过保护，神经元保护，治疗肿瘤，伤口愈合，治疗寄生虫感染和调节造血。 还公开了多肽拮抗剂和用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

公开(公告)号：US06867006B2

公开(公告)日：2005-03-15

申请号：US10141965

申请日：2002-05-10

申请人： Haodong Li ,  Steven M. Ruben ,  Granger Sutton, III

发明人： Haodong Li ,  Steven M. Ruben ,  Granger Sutton, III

IPC分类号： A61K38/00 ,  C07K14/52 ,  C12N15/12 ,  C12N15/19 ,  C07K16/00 ,  C07K16/18 ,  C07K16/22 ,  C07K16/24 ,  C07K16/26

CPC分类号： C07K14/523 ,  A61K38/00

摘要： A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

摘要翻译： 公开了人趋化多肽，编码它的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了将多肽用于多种目的的方法，包括：干细胞动员，髓过保护，神经元保护，治疗肿瘤，伤口愈合，治疗寄生虫感染和调节造血。 还公开了多肽拮抗剂和用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

公开(公告)号：US06419917B1

公开(公告)日：2002-07-16

申请号：US09453416

申请日：1999-12-03

申请人： Haodong Li ,  Steven M. Ruben ,  Granger Sutton, III

发明人： Haodong Li ,  Steven M. Ruben ,  Granger Sutton, III

IPC分类号： A61K3816

CPC分类号： C07K14/523 ,  A61K38/00

摘要： A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

摘要翻译： 公开了人趋化多肽，编码它的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了将多肽用于多种目的的方法，包括：干细胞动员，髓过保护，神经元保护，治疗肿瘤，伤口愈合，治疗寄生虫感染和调节造血。 还公开了多肽拮抗剂和用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

公开(公告)号：US06075124A

公开(公告)日：2000-06-13

申请号：US44856

申请日：1998-03-20

申请人： Haodong Li ,  Steven M. Ruben ,  Granger Sutton, III

发明人： Haodong Li ,  Steven M. Ruben ,  Granger Sutton, III

IPC分类号： A61K38/00 ,  C07K14/52 ,  C07K14/435 ,  C07K14/00

CPC分类号： C07K14/523 ,  A61K38/00

摘要： A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

摘要翻译： 公开了人趋化多肽，编码它的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了将多肽用于多种目的的方法，包括：干细胞动员，髓过保护，神经元保护，治疗肿瘤，伤口愈合，治疗寄生虫感染和调节造血。 还公开了多肽拮抗剂和用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。