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公开(公告)号：US20110218343A1
公开(公告)日：2011-09-08
申请号：US13111543
申请日：2011-05-19
IPC分类号： C07D207/12
CPC分类号： C07D401/06 , A61K31/444 , C07D207/16 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
摘要翻译： 本发明涉及对FKBP型免疫亲和素具有亲和力的神经营养化合物，它们的制备和用作与免疫亲和素蛋白相关的酶活性的抑制剂，特别是肽基 - 脯氨酰异构酶或旋转异构酶活性抑制剂。
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公开(公告)号：US07153883B2
公开(公告)日：2006-12-26
申请号：US09920017
申请日：2001-08-02
IPC分类号： A61K31/40 , C07D207/10
CPC分类号： C07D403/04 , A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/445 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/55 , C07D207/09 , C07D207/12 , C07D207/16 , C07D211/34 , C07D403/06 , C07D405/12 , C07D409/12 , C07D413/04
摘要： This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, for treating alopecia and promoting hair growth, for treating vision disorders and/or improving vision, and for treating memory impairment and/or enhancing memory performance by administering such compounds.
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3.发明授权Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity 失效具有同时阻断L型钙通道并抑制磷酸二酯酶3型活性的化合物公开(公告)号：US07098211B2
公开(公告)日：2006-08-29
申请号：US10679303
申请日：2003-10-07
IPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , A61K31/501
CPC分类号： C07D401/04 , C07D211/90 , C07D213/85 , C07D237/04 , C07D401/12 , C07D487/04
摘要： The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine.
摘要翻译： 本发明提供对PDE-3和L型钙通道具有抑制活性的化合物。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗心血管疾病，中风，癫痫，眼科障碍或偏头痛的方法。
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4.发明授权公开(公告)号：US06429215B1
公开(公告)日：2002-08-06
申请号：US09893568
申请日：2001-06-29
IPC分类号： A61K3144
CPC分类号： A61K8/4926 , A61K8/49 , A61K8/4913 , A61K8/492 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61Q7/00 , Y10S514/88
摘要： This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using an N-oxide of a heterocyclic ester, amide, thioester, or ketone.
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公开(公告)号：US06395758B1
公开(公告)日：2002-05-28
申请号：US09134475
申请日：1998-08-14
IPC分类号： A61K31445
CPC分类号： A61K31/401 , A61K31/17 , A61K31/27 , A61K31/4439
摘要： This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using small molecule carbamates and ureas.
摘要翻译： 本发明涉及用于治疗视力障碍，改善视力，治疗记忆障碍或使用小分子氨基甲酸酯和脲增强记忆性能的药物组合物和方法。
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公开(公告)号：US06384056B1
公开(公告)日：2002-05-07
申请号：US09134424
申请日：1998-08-14
IPC分类号： A61K31445
CPC分类号： A61K31/4025 , A61K31/445
摘要： This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic thioesters and ketones.
摘要翻译： 本发明涉及药物组合物和治疗视力障碍，改善视力，治疗记忆障碍或使用杂环硫酯和酮增强记忆性能的方法。
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7.发明授权Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders 失效具有视觉和记忆障碍的多个杂原子的杂环化合物的羧酸和等离子体公开(公告)号：US06337340B1
公开(公告)日：2002-01-08
申请号：US09134476
申请日：1998-08-14
IPC分类号： A61K31445
CPC分类号： A61K31/675 , A61K31/00 , A61K31/4164 , A61K31/4172 , A61K31/4178 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4439
摘要： This invention relates to novel compositions and uses of carboxylic acid or isostere of a heterocyclic ring compound having two or more heteroatoms within the heterocyclic ring and wherein the heterocyclic ring has at least one substituent attached thereto, the substituent selected from the group consisting of a diketo, a sulfonamide, a urea, a carbamate, and substituted derivatives thereof for treating a vision disorder or improving vision or treating memory impairment or enhancing memory performance in an animal.
摘要翻译： 本发明涉及在杂环中具有两个或更多个杂原子的杂环化合物的羧酸或等排物的新型组合物和用途，其中该杂环具有至少一个与之相连的取代基，该取代基选自二酮 ，磺酰胺，尿素，氨基甲酸酯及其取代的衍生物，用于治疗视力障碍或改善视力或治疗记忆障碍或增强动物的记忆功能。
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公开(公告)号：US06294551B1
公开(公告)日：2001-09-25
申请号：US09516239
申请日：2000-03-01
申请人： Gregory S. Hamilton , Jai-He Li , Wei Huang
发明人： Gregory S. Hamilton , Jai-He Li , Wei Huang
IPC分类号： A61K3147
CPC分类号： C07D207/48 , C07D211/96
摘要： This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
摘要翻译： 本发明涉及对FKBP型免疫亲和素具有亲和性的杂环硫酯的神经营养性低分子量N-连接磺酰胺，以及它们作为与免疫亲和素蛋白特别是肽基 - 脯氨酰异构酶或旋转异构酶相关的酶活性的抑制剂的用途， 酶活性。
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公开(公告)号：US06245783B1
公开(公告)日：2001-06-12
申请号：US09419801
申请日：1999-10-18
IPC分类号： A61K31445
CPC分类号： A61K31/40 , A61K31/18 , A61K31/44 , A61K31/4439 , A61K31/445
摘要： This invention relates to a method of using neurotrophic low molecular weight, small molecule sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
摘要翻译： 本发明涉及使用具有与FKBP型免疫亲和素亲和力的神经营养性低分子量磺酰胺化合物作为与免疫亲和素蛋白特异性肽基 - 脯氨酰异构酶或旋转异构酶相关的酶活性的抑制剂的酶的活性的方法。
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10.发明授权公开(公告)号：US06187806B1
公开(公告)日：2001-02-13
申请号：US09359709
申请日：1999-07-23
IPC分类号： A06K3140
CPC分类号： C07D417/12 , A61K8/4913 , A61K31/00 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/426 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K45/06 , A61K2800/70 , A61Q7/00 , C07D401/06 , C07D401/12 , Y10S514/88
摘要： This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using N-linked sulfonamides of heterocyclic thioesters.
摘要翻译： 本发明涉及使用杂环硫代酯的N-连接磺酰胺治疗脱发并促进毛发生长的药物组合物和方法。
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