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公开(公告)号:US07960570B2
公开(公告)日:2011-06-14
申请号:US12633464
申请日:2009-12-08
IPC分类号: C07D207/16
CPC分类号: C07D401/06 , A61K31/444 , C07D207/16 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
摘要翻译: 本发明涉及对FKBP型免疫亲和素具有亲和力的神经营养化合物,它们的制备和用作与免疫亲和素蛋白相关的酶活性的抑制剂,特别是肽基 - 脯氨酰异构酶或旋转异构酶活性抑制剂。
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公开(公告)号:US20100145071A1
公开(公告)日:2010-06-10
申请号:US12633464
申请日:2009-12-08
IPC分类号: C07D207/16
CPC分类号: C07D401/06 , A61K31/444 , C07D207/16 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
摘要翻译: 本发明涉及对FKBP型免疫亲和素具有亲和力的神经营养化合物,它们的制备和用作与免疫亲和素蛋白相关的酶活性的抑制剂,特别是肽基 - 脯氨酰异构酶或旋转异构酶活性抑制剂。
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公开(公告)号:US20110218343A1
公开(公告)日:2011-09-08
申请号:US13111543
申请日:2011-05-19
IPC分类号: C07D207/12
CPC分类号: C07D401/06 , A61K31/444 , C07D207/16 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
摘要翻译: 本发明涉及对FKBP型免疫亲和素具有亲和力的神经营养化合物,它们的制备和用作与免疫亲和素蛋白相关的酶活性的抑制剂,特别是肽基 - 脯氨酰异构酶或旋转异构酶活性抑制剂。
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4.
公开(公告)号:US20050059693A1
公开(公告)日:2005-03-17
申请号:US10876785
申请日:2004-06-28
申请人: Joseph Steiner , Gregory Hamilton
发明人: Joseph Steiner , Gregory Hamilton
IPC分类号: A61K8/49 , A61K31/00 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/426 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/4745 , A61K45/06 , A61Q7/00 , C07D401/06 , C07D401/12 , C07D417/12
CPC分类号: A61K8/4913 , A61K31/00 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/426 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K45/06 , A61K2800/70 , A61Q7/00 , C07D401/06 , C07D401/12 , C07D417/12 , Y10S514/88
摘要: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using heterocyclic thioesters and ketones.
摘要翻译: 本发明涉及使用杂环硫酯和酮来治疗脱发和促进毛发生长的药物组合物和方法。
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公开(公告)号:US20080090897A1
公开(公告)日:2008-04-17
申请号:US11893100
申请日:2007-08-13
申请人: Joseph Steiner , Avindra Nath , Norman Haughey
发明人: Joseph Steiner , Avindra Nath , Norman Haughey
IPC分类号: A61K31/366
CPC分类号: A61K31/366
摘要: Disclosed herein are neuroprotective compounds. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of neurodegenerative conditions are provided.
摘要翻译: 本文公开了神经保护性化合物。 公开了制备这些化合物的方法。 还公开了包含化合物的药物组合物。 提供了使用单独或与其它治疗剂组合公开的化合物用于治疗神经变性病症的方法。
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公开(公告)号:US20050272780A1
公开(公告)日:2005-12-08
申请号:US11166220
申请日:2005-06-27
申请人: Gregory Hamilton , Joseph Steiner
发明人: Gregory Hamilton , Joseph Steiner
IPC分类号: C12N9/99 , A61K31/00 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/405 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K38/00 , A61K45/00 , A61P21/00 , A61P21/02 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/24 , A61P25/28 , A61P37/00 , A61P43/00 , C07B53/00 , C07D207/16 , C07D401/04 , C07D401/06 , C07D405/06 , C07D405/10 , C07D405/12 , C07D407/04 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/02 , C07D417/04 , C07D417/12 , C07K5/078 , C07D43/02 , C07D49/02
CPC分类号: C07D401/06 , A61K31/444 , C07D207/16 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要: This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
摘要翻译: 本发明涉及对FKBP型免疫亲和素具有亲和性的神经营养的N-乙醛酰脯氨酰酯化合物,它们的制备和用作与免疫亲和素蛋白相关的酶活性的抑制剂,特别是肽基 - 脯氨酰异构酶或旋转异构酶活性的抑制剂。
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公开(公告)号:US20050182870A1
公开(公告)日:2005-08-18
申请号:US10780013
申请日:2004-02-17
申请人: Joseph Steiner , Lloyd Clark , Ramon Hernandez-Marti , Soetjipno Soetandio , Suzanne Richardson
发明人: Joseph Steiner , Lloyd Clark , Ramon Hernandez-Marti , Soetjipno Soetandio , Suzanne Richardson
CPC分类号: E21B47/12
摘要: A wireline logging method including estimating a data rate requirement associated with a tool string to be connected to a wireline cable and determining an operating characteristic of a wireline cable at the surface. The operating characteristic is indicative of the wireline cable's data rate capacity. Before inserting the wireline cable into a well bore, a down hole value of the operating characteristic is modeled and a down hole data rate capacity is derived based thereon. Upon determining that the estimated data rate requirement does not match the down hole data rate capacity, the tool string is modified to remove or add tools to the tools string to match the tool strings data rate requirements with the estimated data rate capacity of the tool string and cable.
摘要翻译: 一种电缆测井方法,包括估计与要连接到有线电缆的工具串相关联的数据速率要求并确定表面处的有线电缆的操作特性。 操作特性表示有线电缆的数据速率容量。 在将有线电缆插入井眼之前,对工作特性的井下值进行建模,并且基于此导出井下数据速率容量。 在确定估计的数据速率要求与井下数据速率容量不匹配时,修改工具串以移除或添加工具字符串的工具,以将工具串数据速率要求与工具串的估计数据速率容量相匹配 和电缆。
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公开(公告)号:US20080076817A1
公开(公告)日:2008-03-27
申请号:US11871358
申请日:2007-10-12
申请人: Gregory Hamilton , Joseph Steiner
发明人: Gregory Hamilton , Joseph Steiner
IPC分类号: A61K31/401 , A61K31/4025 , A61P25/00 , C07D207/16 , C07D405/02
CPC分类号: C07D401/06 , A61K31/444 , C07D207/16 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
摘要翻译: 本发明涉及对FKBP型免疫亲和素具有亲和力的神经营养化合物,它们的制备和用作与免疫亲和素蛋白相关的酶活性的抑制剂,特别是肽基 - 脯氨酰异构酶或旋转异构酶活性抑制剂。
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公开(公告)号:US5435430A
公开(公告)日:1995-07-25
申请号:US297562
申请日:1994-08-31
CPC分类号: B65G47/40 , B65G2201/0211
摘要: There is utilized a particular bucket conveyor apparatus for the transport of fragile articles such as cookies and crackers from an input feed point to a multiple number of discharge areas. At the discharge areas the bucket conveyors are tilted rearwardly to spread the fragile crackers and cookies over a lower transverse belt or vibrating conveyor. In the operation of the apparatus each of the buckets is filled initially to less than about 50 percent of its volume. In this way if there is not an available discharge point, the bucket can once again go through the cycle before it would reach a point of overflowing. When the buckets are in a full condition, they will empty half or more of their contents onto a storage station conveyor prior to passing the input feed point. This bucket conveyor mechanism lends itself to a high degree of computerized control.
摘要翻译: 利用特定的斗式输送机装置将诸如饼干和饼干的脆弱物品从输入进料点输送到多个排放区域。 在排放区域,铲斗输送机向后倾斜,以将易碎的饼干和饼干放在下横向带或振动输送机上。 在装置的操作中,每个桶都开始填充到其体积的不到约50%。 以这种方式,如果没有可用的排放点,则桶可以在它到达溢出点之前再次经过循环。 当水桶处于完全状态时,在通过输入进料点之前,将其一半或更多的内容物清空到储存站输送机上。 这种斗式输送机机构本身具有高度的计算机控制能力。
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