公开(公告)号：US20060256338A1

公开(公告)日：2006-11-16

申请号：US11342273

申请日：2006-01-27

申请人： Enrico Gratton ,  Guido Motolese ,  Abdel Tahari

发明人： Enrico Gratton ,  Guido Motolese ,  Abdel Tahari

IPC分类号： G01N21/64

CPC分类号： G01N15/1463 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2015/0088 ,  G01N2015/1486 ,  G01N2015/1497 ,  G01N2021/6482

摘要： The invention provides methods and devices for detecting, identifying, classifying and characterizing particles in a fluid sample. Optical analyzers are provided having a rotating and/or translating sample container for measuring the concentrations of fluorescent particles present in very low concentrations and for characterizing fluorescent particles on the basis of size, shape, diffusion constant and/or composition. Scanning optical analyzers are provided using pattern recognitions data analysis techniques and multichannel detection.

公开(公告)号：US20090230324A1

公开(公告)日：2009-09-17

申请号：US12415004

申请日：2009-03-31

申请人： Enrico GRATTON ,  Guido MOTOLESE ,  Abdel TAHARI

发明人： Enrico GRATTON ,  Guido MOTOLESE ,  Abdel TAHARI

IPC分类号： G01N21/64

CPC分类号： G01N15/1463 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2015/0088 ,  G01N2015/1486 ,  G01N2015/1497 ,  G01N2021/6482

摘要： The invention provides methods and devices for detecting, identifying, classifying and characterizing particles in a fluid sample. Optical analyzers are provided having a rotating and/or translating sample container for measuring the concentrations of fluorescent particles present in very low concentrations and for characterizing fluorescent particles on the basis of size, shape, diffusion constant and/or composition. Scanning optical analyzers are provided using pattern recognitions data analysis techniques and multichannel detection.

摘要翻译： 本发明提供用于检测，识别，分类和表征流体样品中的颗粒的方法和装置。 提供具有旋转和/或平移样品容器的光学分析器，用于测量以非常低的浓度存在的荧光颗粒的浓度，并且基于尺寸，形状，扩散常数和/或组成来表征荧光颗粒。 使用模式识别数据分析技术和多通道检测来提供扫描光学分析仪。

公开(公告)号：US07528384B2

公开(公告)日：2009-05-05

申请号：US11342273

申请日：2006-01-27

申请人： Enrico Gratton ,  Guido Motolese ,  Abdel Tahari

发明人： Enrico Gratton ,  Guido Motolese ,  Abdel Tahari

IPC分类号： G01N21/64

CPC分类号： G01N15/1463 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2015/0088 ,  G01N2015/1486 ,  G01N2015/1497 ,  G01N2021/6482

摘要： The invention provides methods and devices for detecting, identifying, classifying and characterizing particles in a fluid sample. Optical analyzers are provided having a rotating and/or translating sample container for measuring the concentrations of fluorescent particles present in very low concentrations and for characterizing fluorescent particles on the basis of size, shape, diffusion constant and/or composition. Scanning optical analyzers are provided using pattern recognitions data analysis techniques and multichannel detection.

摘要翻译： 本发明提供用于检测，识别，分类和表征流体样品中的颗粒的方法和装置。 提供具有旋转和/或平移样品容器的光学分析器，用于测量以非常低的浓度存在的荧光颗粒的浓度，并且基于尺寸，形状，扩散常数和/或组成来表征荧光颗粒。 使用模式识别数据分析技术和多通道检测来提供扫描光学分析仪。

公开(公告)号：US07973294B2

公开(公告)日：2011-07-05

申请号：US12415004

申请日：2009-03-31

申请人： Enrico Gratton ,  Guido Motolese ,  Abdel Tahari

发明人： Enrico Gratton ,  Guido Motolese ,  Abdel Tahari

IPC分类号： G01N21/64

CPC分类号： G01N15/1463 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2015/0088 ,  G01N2015/1486 ,  G01N2015/1497 ,  G01N2021/6482

摘要： The invention provides methods and devices for detecting, identifying, classifying and characterizing particles in a fluid sample. Optical analyzers are provided having a rotating and/or translating sample container for measuring the concentrations of fluorescent particles present in very low concentrations and for characterizing fluorescent particles on the basis of size, shape, diffusion constant and/or composition. Scanning optical analyzers are provided using pattern recognitions data analysis techniques and multichannel detection.

摘要翻译： 本发明提供了用于检测，识别，分类和表征流体样品中的颗粒的方法和装置。 提供具有旋转和/或平移样品容器的光学分析器，用于测量以非常低的浓度存在的荧光颗粒的浓度，并且基于尺寸，形状，扩散常数和/或组成来表征荧光颗粒。 使用模式识别数据分析技术和多通道检测来提供扫描光学分析仪。

公开(公告)号：US5371350A

公开(公告)日：1994-12-06

申请号：US93825

申请日：1993-07-20

申请人： Guido Motolese

发明人： Guido Motolese

IPC分类号： G01J1/04 ,  G01N21/76

CPC分类号： G01J1/04 ,  G01J1/044 ,  G01N21/76 ,  G01J1/0204 ,  G01J1/0223

摘要： An electronic device for measuring extremely faint light emissions comprises a photomultiplier tube surrounded by a sleeve made of a material which is a good heat conductor, cooled to a low temperature and insulated from the outside, a thermally insulating and optically transparent lightguide body being stably glued to the photocathode of the photomultiplier tube to receive the light radiation emitted by a specimen to be examined, which is inserted in a cavity of a supporting structure holding a rotary body which can be turned in front of the lightguide body, so as to operate as a shutter for the lightguide in a first turned measurement position thereof to allow measurement of the dark signal and then allow, as the rotary body and the specimen held therein are turned to a second measurement position, to measure the light emission from the specimen.

摘要翻译： 用于测量极微弱发光的电子设备包括光电倍增管，该光电倍增管被由被冷却至低温并与外部绝缘的良好热导体的材料制成的套筒包围，该绝缘和光学透明的光导体被稳定地胶合 到光电倍增管的光电阴极，以接收由待检查样本发射的光辐射，其被插入到保持可转动在光导体前面的旋转体的支撑结构的空腔中，以便作为 用于在第一转动测量位置中的光导的快门，以允许测量暗信号，然后当保持在其中的旋转体和样本转到第二测量位置时，允许测量来自样本的光发射。