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公开(公告)号：US20160015787A1
公开(公告)日：2016-01-21
申请号：US14630184
申请日：2015-02-24
发明人： Kuniaki Yoshioka , Ko Sato , Toru Gotanda , Akira Ito , Emiko Isogai , Kazuaki Takehara , Nobutoshi Maehara
CPC分类号： A61K38/212 , A23K20/147 , A23K50/40 , A23L33/10 , A23L33/17 , A23V2002/00 , A61K9/0063
摘要： The present invention provides oral compositions which contain interferon α (IFNα) as an active ingredient for preventing and/or treating periodontal disease. The number of causative microorganisms of periodontal disease can be suppressed by administering the compositions into the oral cavity. IFNα of the present invention can produce a sufficient effect even when administered at a very low dose. Furthermore, the compositions of the present invention can also be readily administered to animals such as dogs by formulating them into feed or such.
摘要翻译： 本发明提供含有干扰素α（IFNα）作为预防和/或治疗牙周病的活性成分的口服组合物。 牙周病的致病微生物的数量可以通过将组合物施用于口腔来抑制。 即使以非常低的剂量施用，本发明的IFNα也能产生足够的效果。 此外，本发明的组合物还可以通过将它们配制成饲料等而容易地施用于动物如狗。
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公开(公告)号：US09629900B2
公开(公告)日：2017-04-25
申请号：US14630184
申请日：2015-02-24
发明人： Kuniaki Yoshioka , Ko Sato , Toru Gotanda , Akira Ito , Emiko Isogai , Kazuaki Takehara , Nobutoshi Maehara
IPC分类号： A61K38/21 , A61K38/00 , A61K47/00 , A61K9/00 , A23K20/147 , A23K50/40 , A23L33/10 , A23L33/17
CPC分类号： A61K38/212 , A23K20/147 , A23K50/40 , A23L33/10 , A23L33/17 , A23V2002/00 , A61K9/0063
摘要： The present invention provides oral compositions which contain interferon α (IFNα) as an active ingredient for preventing and/or treating periodontal disease. The number of causative microorganisms of periodontal disease can be suppressed by administering the compositions into the oral cavity. IFNα of the present invention can produce a sufficient effect even when administered at a very low dose. Furthermore, the compositions of the present invention can also be readily administered to animals such as dogs by formulating them into feed or such.
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3.发明申请公开(公告)号：US20190029953A1
公开(公告)日：2019-01-31
申请号：US15562870
申请日：2016-01-12
发明人： Akira Ito , Takeshi Matsumura , Toru Gotanda , Noriko Tabayashi , Noriko Itchoda , Takashi Aoki , Uiko Kagaya
CPC分类号： A61K9/0053 , A23L33/00 , A61K9/0056 , A61K9/0058 , A61K9/20 , A61K38/212 , A61P27/16
摘要： The object of the present invention is to provide a therapeutic agent illustrating an immediate and sustained effect on chronic intractable external otitis. The present invention provide a composition, pharmaceutical composition, food and feed for preventing and/or treating chronic intractable external otitis, each comprising interferon-α (IFNα) as an active ingredient. Orally administering the composition of the present invention can provide inhibition, alleviation, treatment and prevention for chronic intractable external otitis. According to the present invention, IFNα can give a sufficient effect even when administered in a very small amount.
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公开(公告)号：US09937271B2
公开(公告)日：2018-04-10
申请号：US15039628
申请日：2014-11-25
申请人： IDEMITSU KOSAN CO., LTD. , NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY , HOKUSAN CO. LTD
发明人： Kazutoshi Sawada , Takeshi Matsui , Eiji Takita , Takeshi Matsumura , Akira Ito , Noriko Tabayashi
IPC分类号： A61K38/00 , A61K48/00 , A61K39/108
CPC分类号： A61K48/005 , A23K20/00 , A23K50/30 , A61K38/00 , A61K39/0258 , A61K2039/552 , C07K14/245 , C07K14/25 , Y02A50/474
摘要： The present invention provides an agent for controlling Escherichia coli diarrhea comprising a Shiga toxin as an active ingredient.
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公开(公告)号：US20210292382A1
公开(公告)日：2021-09-23
申请号：US16330623
申请日：2017-09-04
申请人： Hokusan Co. Ltd. , National Institute of Advanced Industrial Science and Technology , School Juridical Person The Kitasato Institute
发明人： Noriko Tabayashi , Toru Gotanda , Hanae Sasaki , Noriko Itchoda , Uiko Kagaya , Takeshi Matsumura , Akira Ito , Hiromi Ikadai
IPC分类号： C07K14/445 , A61K39/015 , A61K9/00 , A61P33/06 , C12N15/82
摘要： It is an object of the present invention to provide a transmission-blocking vaccine using an immunogenic protein which is specifically expressed in the oocyst stage of malaria parasites or a peptide fragment thereof, and an oral transmission-blocking vaccine capable of immunizing various animals involved in the malaria infectious cycle with such a vaccine.
The present invention relates to a malaria transmission-blocking vaccine for oral administration containing an immunogenic protein derived from malaria parasite which is specifically expressed in the oocyst stage of malaria parasites or a peptide fragment thereof, and a method of blocking the transmission of malaria using the same.-
公开(公告)号：US11427620B2
公开(公告)日：2022-08-30
申请号：US16330623
申请日：2017-09-04
申请人： Hokusan Co. Ltd. , National Institute of Advanced Industrial Science and Technology , School Juridical Person The Kitasato Institute
发明人： Noriko Tabayashi , Toru Gotanda , Hanae Sasaki , Noriko Itchoda , Uiko Kagaya , Takeshi Matsumura , Akira Ito , Hiromi Ikadai
IPC分类号： A61K39/015 , C07K14/445 , A61K39/00 , C12N15/82 , A61P33/06 , A61K9/00
摘要： It is an object of the present invention to provide a transmission-blocking vaccine using an immunogenic protein which is specifically expressed in the oocyst stage of malaria parasites or a peptide fragment thereof, and an oral transmission-blocking vaccine capable of immunizing various animals involved in the malaria infectious cycle with such a vaccine.
The present invention relates to a malaria transmission-blocking vaccine for oral administration containing an immunogenic protein derived from malaria parasite which is specifically expressed in the oocyst stage of malaria parasites or a peptide fragment thereof, and a method of blocking the transmission of malaria using the same.-
7.发明授权公开(公告)号：US10799448B2
公开(公告)日：2020-10-13
申请号：US15562870
申请日：2016-01-12
发明人： Akira Ito , Takeshi Matsumura , Toru Gotanda , Noriko Tabayashi , Noriko Itchoda , Takashi Aoki , Uiko Kagaya
摘要： The object of the present invention is to provide a therapeutic agent illustrating an immediate and sustained effect on chronic intractable external otitis. The present invention provide a composition, pharmaceutical composition, food and feed for preventing and/or treating chronic intractable external otitis, each comprising interferon-α (IFNα) as an active ingredient. Orally administering the composition of the present invention can provide inhibition, alleviation, treatment and prevention for chronic intractable external otitis. According to the present invention, IFNα can give a sufficient effect even when administered in a very small amount.
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公开(公告)号：US20170173179A1
公开(公告)日：2017-06-22
申请号：US15039628
申请日：2014-11-25
申请人： IDEMITSU KOSAN CO., LTD. , NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY , HOKUSAN CO. LTD
发明人： Kazutoshi SAWADA , Takeshi MATSUI , Eiji TAKITA , Takeshi MATSUMURA , Akira ITO , Noriko TABAYASHI
IPC分类号： A61K48/00 , A61K39/108 , A61K38/00
CPC分类号： A61K48/005 , A23K20/00 , A23K50/30 , A61K38/00 , A61K39/0258 , A61K2039/552 , C07K14/245 , C07K14/25 , Y02A50/474
摘要： The present invention provides an agent for controlling Escherichia coli diarrhea comprising a Shiga toxin as an active ingredient.
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