公开(公告)号：US20230302050A1

公开(公告)日：2023-09-28

申请号：US17925411

申请日：2021-05-20

申请人： Institut Curie ,  Centre National de la Recherche Scientifique ,  The University of Zurich ,  Honing Biosciences

发明人： Sandrine Moutel ,  Franck Perez ,  Michele Bernasconi ,  Nagjie Laila Alijaj ,  Zélia Gouveia

IPC分类号： A61K35/17 ,  C12N15/63 ,  C07K16/28 ,  G01N33/574

CPC分类号： A61K35/17 ,  C12N15/63 ,  C07K16/2863 ,  G01N33/574 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/567

摘要： The present application relates to fully humanized anti-FGFR4 single domain antibodies (sdAbs) and variants thereof. The present invention further relates to functionalized drug nanocarriers, nucleic acids, vectors, host cells, immune cells comprising said sdAbs, and compositions comprising thereof, as well as their use for therapy.

公开(公告)号：US20240317890A1

公开(公告)日：2024-09-26

申请号：US18269615

申请日：2022-01-14

申请人： INSTITUT CURIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  HONING BIOSCIENCES

发明人： Franck PEREZ ,  Sandrine MOUTEL ,  Zélia GOUVEIA

IPC分类号： C07K16/32 ,  A61K39/00 ,  C07K14/705 ,  C07K14/725 ,  G01N33/574

CPC分类号： C07K16/32 ,  C07K14/7051 ,  C07K14/70578 ,  G01N33/57484 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/569 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/03

摘要： The present invention relates to humanized HER2 single domain antibodies and variants thereof and their use in therapy and for cancer diagnosis. The invention most particularly proposes chimeric antigen receptors including said humanized HER2 sdAb in their antigen binding domain and their use in cancer cell therapy.

公开(公告)号：US20240084354A1

公开(公告)日：2024-03-14

申请号：US18252941

申请日：2021-11-15

申请人： HONING BIOSCIENCES ,  INSTITUT CURIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Franck PEREZ ,  Zelia GOUVEIA

IPC分类号： C12P21/00 ,  C07K14/36 ,  C07K14/54 ,  C07K14/55 ,  C12N15/85

CPC分类号： C12P21/005 ,  C07K14/36 ,  C07K14/5434 ,  C07K14/55 ,  C12N15/85 ,  C07K2319/04 ,  C07K2319/20 ,  C12N2740/15043 ,  C12N2830/002

摘要： The present invention relates to a polynucleotide comprising a gene encoding a hook protein and a gene encoding a protein of interest, said protein of interest being either a secretory protein or a cell membrane-anchored protein, wherein:



said gene encoding the hook protein is under the control of a first transcription-activating signal,
said gene encoding the protein of interest is under the control of a second transcription-activating signal, said second transcription-activating signal allowing a lower rate or frequency of transcription initiation than the first transcription-activating signal,
said hook protein is fused to a cellular compartment-retention peptide, and
said protein of interest is fused to a hook protein-binding domain




It also related to vectors comprising the polynucleotide, cells comprising the polynucleotide or the vector and compositions comprising the same. It further relates to methods and uses for modulating the secretion or cell membrane-anchorage of a protein of interest, or for preventing and/or treating a disease in a subject in need thereof.