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公开(公告)号：US20230302050A1
公开(公告)日：2023-09-28
申请号：US17925411
申请日：2021-05-20
申请人： Institut Curie , Centre National de la Recherche Scientifique , The University of Zurich , Honing Biosciences
IPC分类号： A61K35/17 , C12N15/63 , C07K16/28 , G01N33/574
CPC分类号： A61K35/17 , C12N15/63 , C07K16/2863 , G01N33/574 , C07K2317/565 , C07K2317/569 , C07K2317/567
摘要： The present application relates to fully humanized anti-FGFR4 single domain antibodies (sdAbs) and variants thereof. The present invention further relates to functionalized drug nanocarriers, nucleic acids, vectors, host cells, immune cells comprising said sdAbs, and compositions comprising thereof, as well as their use for therapy.
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公开(公告)号：US20210347855A1
公开(公告)日：2021-11-11
申请号：US17190626
申请日：2021-03-03
申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) , Institut Curie , Universite Paul Sabatier Toulouse III , Centre National de la Recherche Scientifique (CNRS)
发明人： Aurelien Olichon , Sandrine Moutel , Franck Perez
摘要： The invention relates to the identification of a highly stable single domain antibody scaffold (hs2dAb) and its use in generating synthetic single domain antibody library (hs2dAb-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
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公开(公告)号：US10968281B2
公开(公告)日：2021-04-06
申请号：US16341529
申请日：2017-10-13
申请人： INSTITUT CURIE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
IPC分类号： A61K39/395 , A61K39/00 , G01N33/53 , C07K16/46 , C07K16/00 , C07K16/30 , G01N33/50 , A61K38/00
摘要： The present invention provides a new anti-LSP1 (Leukocyte specific protein 1) antibody. This new antibody allows the specific staining of inflammatory dendritic cells and can be used in diagnosis methods or as a medicament when conjugated to a drug.
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公开(公告)号：US20180327481A1
公开(公告)日：2018-11-15
申请号：US16016738
申请日：2018-06-25
申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) , Institut Curie , Universite Paul Sabatier Toulouse III , Centre National de la Recherche Scientifique (CNRS)
发明人： Aurelien Olichon , Sandrine Moutel , Franck Perez
CPC分类号： C07K16/005 , C07K16/32 , C07K16/40 , C07K16/44 , C07K2317/22 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/80 , C07K2317/92 , C40B40/10 , C40B50/06
摘要： The invention relates to the identification of a highly stable single domain antibody scaffold (hs2dAb) and its use in generating synthetic single domain antibody library (hs2dAb-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
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公开(公告)号：US10017559B2
公开(公告)日：2018-07-10
申请号：US15030541
申请日：2014-11-04
申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) , Institut Curie , Universite Paul Sabatier Toulouse III , Centre National de la Recherche Scientifique (CNRS)
发明人： Aurellen Olichon , Sandrine Moutel , Franck Perez
CPC分类号： C07K16/005 , C07K16/32 , C07K16/40 , C07K16/44 , C07K2317/22 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/80 , C07K2317/92 , C40B40/10 , C40B50/06
摘要： The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain antibody library (hs2d Ab-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
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公开(公告)号：US20160237142A1
公开(公告)日：2016-08-18
申请号：US15030541
申请日：2014-11-04
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , INSTITUT CURIE , UNIVERSITE PAUL SABATIER TOULOUSE III , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS
发明人： Aurellen Olichon , Sandrine Moutel , Franck Perez
CPC分类号： C07K16/005 , C07K16/32 , C07K16/40 , C07K16/44 , C07K2317/22 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/80 , C07K2317/92 , C40B40/10 , C40B50/06
摘要： The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain antibody library (hs2d Ab-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
摘要翻译： 本发明涉及高稳定性单结构域抗体支架（hs2d Ab）的鉴定及其在产生合成单结构域抗体文库（hs2d Ab-L1）中的应用。 本发明还涉及包含所述稳定单结构域抗体支架及其用途，特别是作为治疗剂的抗原结合蛋白。
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公开(公告)号：US10030068B2
公开(公告)日：2018-07-24
申请号：US15638509
申请日：2017-06-30
申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) , Institut Curie , Universite Paul Sabatier Toulouse III , Centre National de la Recherche Scientifique (CNRS)
发明人： Aurelien Olichon , Sandrine Moutel , Franck Perez
摘要： The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain antibody library (hs2d Ab-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
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公开(公告)号：US20180030117A1
公开(公告)日：2018-02-01
申请号：US15638509
申请日：2017-06-30
申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) , Institut Curie , Universite Paul Sabatier Toulouse III , Centre National de la Recherche Scientifique (CNRS)
发明人： Aurelien Olichon , Sandrine Moutel , Franck Perez
CPC分类号： C07K16/005 , C07K16/32 , C07K16/40 , C07K16/44 , C07K2317/22 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/80 , C07K2317/92 , C40B40/10 , C40B50/06
摘要： The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain antibody library (hs2d Ab-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
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公开(公告)号：US11866484B2
公开(公告)日：2024-01-09
申请号：US17190626
申请日：2021-03-03
申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) , Institut Curie , Universite Paul Sabatier Toulouse III , Centre National de la Recherche Scientifique (CNRS)
发明人： Aurelien Olichon , Sandrine Moutel , Franck Perez
CPC分类号： C07K16/005 , C07K16/32 , C07K16/40 , C07K16/44 , C40B40/08 , C07K2317/22 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/80 , C07K2317/92 , C40B40/10 , C40B50/06
摘要： The invention relates to the identification of a highly stable single domain antibody scaffold (hs2dAb) and its use in generating synthetic single domain antibody library (hs2dAb-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
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公开(公告)号：US20230183675A1
公开(公告)日：2023-06-15
申请号：US17925401
申请日：2021-05-20
发明人： Franck Perez , Sandrine Moutel
CPC分类号： C12N15/1037 , C07K16/005 , C07K16/2863 , C07K2317/569 , C07K2317/565 , C07K2317/567 , C07K2317/92 , C07K2317/24
摘要： The present invention relates to the identification of a fully humanized single domain antibody scaffold as well as its use in generating synthetic single domain antibodies. The invention further relates to antigen-binding proteins comprising said single domain antibody scaffold and their use in therapy.
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