HYALURONIC ACID DERIVATIVE EFFECTIVE AGAINST ATOPIC DERMATITIS, AND METHOD FOR MANUFACTURING SAME
    2.
    发明申请
    HYALURONIC ACID DERIVATIVE EFFECTIVE AGAINST ATOPIC DERMATITIS, AND METHOD FOR MANUFACTURING SAME 审中-公开
    抗真菌药物的杀真菌剂衍生物及其制备方法

    公开(公告)号:US20120283428A1

    公开(公告)日:2012-11-08

    申请号:US13513133

    申请日:2010-09-13

    IPC分类号: C08B37/08

    CPC分类号: A61K31/728 C08B37/0072

    摘要: Disclosed are a hyaluronic acid derivative effective against atopic dermatitis, and a method for manufacturing same. The method for manufacturing the hyaluronic acid derivative of the present invention comprises: a first step of chlorinating ascorbic acid; a second step of producing a tetrabutylamonium hydroxide (TBA) salt of hyaluronic acid; and a third step of conjugating the ascorbic acid chlorinated in the first step and the TBA salt of hyaluronic acid produced in the second step. The hyaluronic acid derivative can effectively decrease the substances causing skin lesions, can contribute toward the remission of atopic disease, and is effective in skin renewal.

    摘要翻译: 公开了对抗特应性皮炎有效的透明质酸衍生物及其制造方法。 本发明的透明质酸衍生物的制造方法包括:将抗坏血酸氯化的第一工序; 生产透明质酸的四丁基氢氧化铵(TBA)盐的第二步骤; 以及将第一步中氯化的抗坏血酸与第二步产生的透明质酸的TBA盐共轭的第三步骤。 透明质酸衍生物可以有效减少引起皮肤损伤的物质,有助于缓解特应性疾病,并且对皮肤更新有效。