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公开(公告)号：US12077791B2
公开(公告)日：2024-09-03
申请号：US18339829
申请日：2023-06-22
申请人： HALOZYME, INC.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C07K14/00 , A61K9/00 , A61K38/00 , A61K38/16 , A61K38/28 , A61K38/43 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12N9/26 , C12Q1/34
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/28 , A61K2300/00 , A61K38/47 , A61K2300/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US12104185B2
公开(公告)日：2024-10-01
申请号：US18599428
申请日：2024-03-08
申请人： Halozyme, Inc.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , A61K9/00 , A61K38/00 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/28 , A61K2300/00 , A61K38/47 , A61K2300/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US12037618B2
公开(公告)日：2024-07-16
申请号：US17327586
申请日：2021-05-21
申请人： HALOZYME, INC.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , A61K9/00 , A61K38/00 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/28 , A61K2300/00 , A61K38/47 , A61K2300/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US20240011008A1
公开(公告)日：2024-01-11
申请号：US18338189
申请日：2023-06-20
申请人： HALOZYME,INC.
发明人： Ge WEI , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , A61K38/47 , A61K38/28 , A61K45/06 , A61K9/00 , A61K47/10 , C12Q1/34 , A61P35/00 , C07K14/47
CPC分类号： C12N9/2474 , A61K38/47 , A61K38/28 , A61K45/06 , C12Y302/01035 , A61K9/0019 , A61K47/10 , C12Q1/34 , A61P35/00 , C07K14/47 , G01N2333/926 , G01N2333/928 , Y02A50/30 , C07K2319/30 , A61K38/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US20230295593A1
公开(公告)日：2023-09-21
申请号：US18068218
申请日：2022-12-19
申请人： HALOZYME, INC.
发明人： Ge WEI , H. Michael Shepard , Qiping Zhao , Robert James Connor
CPC分类号： C12N9/2474 , A61K38/47 , A61K38/28 , A61K45/06 , C12Y302/01035 , A61K9/0019 , A61K47/10 , C12Q1/34 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US12091692B2
公开(公告)日：2024-09-17
申请号：US17327568
申请日：2021-05-21
申请人： HALOZYME, INC.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： A61K38/28 , A61K9/00 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12N9/26 , C12Q1/34 , A61K38/00
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/28 , A61K2300/00 , A61K38/47 , A61K2300/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US12054758B2
公开(公告)日：2024-08-06
申请号：US18066960
申请日：2022-12-15
申请人： HALOZYME, INC.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , A61K9/00 , A61K38/00 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P3/04 , A61P3/10 , A61P11/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12Q1/34
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/28 , A61K2300/00 , A61K38/47 , A61K2300/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US12049652B2
公开(公告)日：2024-07-30
申请号：US18064886
申请日：2022-12-12
申请人： HALOZYME, INC.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , A61K9/00 , A61K38/00 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P3/04 , A61P3/10 , A61P11/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12Q1/34
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/28 , A61K2300/00 , A61K38/47 , A61K2300/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US20240026327A1
公开(公告)日：2024-01-25
申请号：US18339829
申请日：2023-06-22
申请人： HALOZYME, INC.
发明人： Ge WEI , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , A61K38/47 , A61K38/28 , A61K45/06 , A61K9/00 , A61K47/10 , C12Q1/34 , A61P35/00 , C07K14/47
CPC分类号： C12N9/2474 , A61K38/47 , A61K38/28 , A61K45/06 , C12Y302/01035 , A61K9/0019 , A61K47/10 , C12Q1/34 , A61P35/00 , C07K14/47 , G01N2333/926 , G01N2333/928 , Y02A50/30 , C07K2319/30 , A61K38/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US20240002826A1
公开(公告)日：2024-01-04
申请号：US18340786
申请日：2023-06-23
申请人： HALOZYME, INC.
发明人： Ge WEI , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , A61K38/47 , A61K38/28 , A61K45/06 , A61K9/00 , A61K47/10 , C12Q1/34 , A61P35/00 , C07K14/47
CPC分类号： C12N9/2474 , A61K38/47 , A61K38/28 , A61K45/06 , C12Y302/01035 , A61K9/0019 , A61K47/10 , C12Q1/34 , A61P35/00 , C07K14/47 , G01N2333/926 , G01N2333/928 , Y02A50/30 , C07K2319/30 , A61K38/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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