公开(公告)号：US12077791B2

公开(公告)日：2024-09-03

申请号：US18339829

申请日：2023-06-22

申请人： HALOZYME, INC.

发明人： Ge Wei ,  H. Michael Shepard ,  Qiping Zhao ,  Robert James Connor

IPC分类号： C07K14/00 ,  A61K9/00 ,  A61K38/00 ,  A61K38/16 ,  A61K38/28 ,  A61K38/43 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61P35/00 ,  C07K14/47 ,  C12N9/26 ,  C12Q1/34

CPC分类号： C12N9/2474 ,  A61K9/0019 ,  A61K38/28 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/34 ,  C12Y302/01035 ,  A61K38/00 ,  C07K2319/30 ,  G01N2333/926 ,  G01N2333/928 ,  Y02A50/30 ,  A61K38/28 ,  A61K2300/00 ,  A61K38/47 ,  A61K2300/00

摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

公开(公告)号：US11414489B2

公开(公告)日：2022-08-16

申请号：US15444151

申请日：2017-02-27

申请人： HALOZYME, INC.

发明人： Sanna Rosengren ,  H. Michael Shepard ,  Curtis B. Thompson

IPC分类号： C07K16/28 ,  A61K38/47 ,  A61K39/395 ,  C12N9/26 ,  A61K9/00 ,  A61K31/573 ,  A61P35/00 ,  C12N15/00 ,  A61K47/60 ,  A61K39/00 ,  A61K9/127

摘要： Provided are methods of treatments with combinations or compositions containing a soluble hyaluronidase, such as a polymer-modified hyaluronidase, and an immune checkpoint inhibitor treating cancers, including solid and non-solid tumors. The combinations and compositions also are provided.

公开(公告)号：US20170290796A1

公开(公告)日：2017-10-12

申请号：US15625177

申请日：2017-06-16

申请人： Halozyme, Inc.

发明人： Daniel C. Maneval ,  H. Michael Shepard ,  Curtis B. Thompson

IPC分类号： A61K31/337 ,  C12N9/26 ,  A61K9/00 ,  C12N9/06 ,  A61K31/56 ,  A61K31/7076 ,  A61K38/47 ,  A61K31/37

CPC分类号： A61K31/337 ,  A61K9/0019 ,  A61K31/37 ,  A61K31/42 ,  A61K31/56 ,  A61K31/573 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/7076 ,  A61K31/7088 ,  A61K38/47 ,  A61K45/06 ,  A61K47/56 ,  A61K47/60 ,  A61K47/643 ,  C12N9/003 ,  C12N9/2474 ,  C12Y105/01003 ,  C12Y302/01035 ,  A61K2300/00

摘要： Provided herein is combination cancer therapy effected by administering a polymer-conjugated hyaluronidase, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.

公开(公告)号：US12104185B2

公开(公告)日：2024-10-01

申请号：US18599428

申请日：2024-03-08

申请人： Halozyme, Inc.

发明人： Ge Wei ,  H. Michael Shepard ,  Qiping Zhao ,  Robert James Connor

IPC分类号： C12N9/26 ,  A61K9/00 ,  A61K38/00 ,  A61K38/28 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/34

CPC分类号： C12N9/2474 ,  A61K9/0019 ,  A61K38/28 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/34 ,  C12Y302/01035 ,  A61K38/00 ,  C07K2319/30 ,  G01N2333/926 ,  G01N2333/928 ,  Y02A50/30 ,  A61K38/28 ,  A61K2300/00 ,  A61K38/47 ,  A61K2300/00

摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

公开(公告)号：US12037618B2

公开(公告)日：2024-07-16

申请号：US17327586

申请日：2021-05-21

申请人： HALOZYME, INC.

发明人： Ge Wei ,  H. Michael Shepard ,  Qiping Zhao ,  Robert James Connor

IPC分类号： C12N9/26 ,  A61K9/00 ,  A61K38/00 ,  A61K38/28 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/34

CPC分类号： C12N9/2474 ,  A61K9/0019 ,  A61K38/28 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/34 ,  C12Y302/01035 ,  A61K38/00 ,  C07K2319/30 ,  G01N2333/926 ,  G01N2333/928 ,  Y02A50/30 ,  A61K38/28 ,  A61K2300/00 ,  A61K38/47 ,  A61K2300/00

摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

公开(公告)号：US20240011008A1

公开(公告)日：2024-01-11

申请号：US18338189

申请日：2023-06-20

申请人： HALOZYME,INC.

发明人： Ge WEI ,  H. Michael Shepard ,  Qiping Zhao ,  Robert James Connor

IPC分类号： C12N9/26 ,  A61K38/47 ,  A61K38/28 ,  A61K45/06 ,  A61K9/00 ,  A61K47/10 ,  C12Q1/34 ,  A61P35/00 ,  C07K14/47

CPC分类号： C12N9/2474 ,  A61K38/47 ,  A61K38/28 ,  A61K45/06 ,  C12Y302/01035 ,  A61K9/0019 ,  A61K47/10 ,  C12Q1/34 ,  A61P35/00 ,  C07K14/47 ,  G01N2333/926 ,  G01N2333/928 ,  Y02A50/30 ,  C07K2319/30 ,  A61K38/00

摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

公开(公告)号：US20230295593A1

公开(公告)日：2023-09-21

申请号：US18068218

申请日：2022-12-19

申请人： HALOZYME, INC.

发明人： Ge WEI ,  H. Michael Shepard ,  Qiping Zhao ,  Robert James Connor

IPC分类号： C12N9/26 ,  A61K38/47 ,  A61K38/28 ,  A61K45/06 ,  A61K9/00 ,  A61K47/10 ,  C12Q1/34

CPC分类号： C12N9/2474 ,  A61K38/47 ,  A61K38/28 ,  A61K45/06 ,  C12Y302/01035 ,  A61K9/0019 ,  A61K47/10 ,  C12Q1/34 ,  G01N2333/926 ,  G01N2333/928 ,  Y02A50/30 ,  A61K38/00

摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

公开(公告)号：US11584923B2

公开(公告)日：2023-02-21

申请号：US15940803

申请日：2018-03-29

申请人： Halozyme, Inc.

发明人： Christopher D. Thanos ,  Lin Wang ,  H. Michael Shepard

IPC分类号： C12N9/78 ,  A61K38/48 ,  A61K38/00

摘要： Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates. Also provided are methods and uses of the ADA2 proteins or conjugates for treating diseases and conditions, such as a tumor or cancer, and in particular any disease or condition associated with elevated adenosine or other associated marker.

公开(公告)号：US10137104B2

公开(公告)日：2018-11-27

申请号：US15625177

申请日：2017-06-16

申请人： Halozyme, Inc.

发明人： Daniel C. Maneval ,  H. Michael Shepard ,  Curtis B. Thompson

IPC分类号： A61K31/337 ,  C12N9/26 ,  A61K9/00 ,  C12N9/06 ,  A61K31/56 ,  A61K38/47 ,  A61K31/37 ,  A61K31/42 ,  A61K31/573 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/7076 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/60 ,  A61K47/56 ,  A61K47/64 ,  A61K47/48

摘要： Provided herein is combination cancer therapy effected by administering a polymer-conjugated hyaluronidase, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.

公开(公告)号：US20170166878A9

公开(公告)日：2017-06-15

申请号：US15094908

申请日：2016-04-08

申请人： Halozyme, Inc.

发明人： Christopher D. Thanos ,  Lin Wang ,  H. Michael Shepard

IPC分类号： C12N9/78 ,  A61K38/48

CPC分类号： C12N9/78 ,  A61K38/00 ,  A61K38/48 ,  C12Y305/04004

摘要： Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates. Also provided are methods and uses of the ADA2 proteins or conjugates for treating diseases and conditions, such as a tumor or cancer, and in particular any disease or condition associated with elevated adenosine or other associated marker.