公开(公告)号：US10271941B2

公开(公告)日：2019-04-30

申请号：US13090479

申请日：2011-04-20

Applicant: Daniel Wintsch ,  Stefan Loher ,  Bodo Quint ,  Patrice Bachmann ,  Hans Lang ,  Dragica Pantic ,  Alwin Schwitzer

Inventor： Daniel Wintsch ,  Stefan Loher ,  Bodo Quint ,  Patrice Bachmann ,  Hans Lang ,  Dragica Pantic ,  Alwin Schwitzer

IPC: A61F2/08 ,  A61F2/07 ,  A61L31/06 ,  A61F2/90

Abstract: An implant having a preferably hollow cylindrical basic structure. A nonwoven fabric is disposed in and/or on the basic structure, the nonwoven fabric preferably comprising biocompatible thermoplastic polyurethane and/or a polymer selected from the group consisting of polylactic acid; polycaprolactone, and a copolymer thereof, and/or a polymer including polyphosphazene. At least in at least one section of the implant, preferably at the proximal and/or distal ends of the implant, fastening means are provided or the nonwoven fabric is treated such that, at least in the expanded state of the implant, the protrusion of nonwoven fabric sections from the implant is significantly reduced. Furthermore, a method for producing such an implant is provided.

公开(公告)号：US20120290082A1

公开(公告)日：2012-11-15

申请号：US13458015

申请日：2012-04-27

Applicant: Bodo Quint ,  Matthias Wesselmann ,  Alwin Schwitzer ,  Patrice Bachmann ,  Susanne Pfenninger-Ganz ,  Hans Lang ,  Amir Fargahi

Inventor： Bodo Quint ,  Matthias Wesselmann ,  Alwin Schwitzer ,  Patrice Bachmann ,  Susanne Pfenninger-Ganz ,  Hans Lang ,  Amir Fargahi

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2210/0076 ,  A61F2250/0018 ,  A61F2250/0029

Abstract: A mechanical transcatheter heart valve prosthesis including a support structure that can be expanded from a first size designed for minimally invasive insertion to a functional second size and a flexible heart valve made of a composite material containing woven fabric that is embedded in an elastic matrix and locally reinforced by fibers, the heart valve comprising a plurality of leaflets.

Abstract translation: 一种机械性经导管心脏瓣膜假体，其包括可以从设计用于微创插入的第一尺寸扩展到功能性第二尺寸的支撑结构，以及由包含嵌入在弹性基质中的本机织物的复合材料制成的柔性心脏瓣膜 由纤维增强，心脏瓣膜包括多个传单。

公开(公告)号：US20110202001A1

公开(公告)日：2011-08-18

申请号：US13023921

申请日：2011-02-09

Applicant: Matthias Wesselmann ,  Hans Lang ,  Susanne Pfenninger-Ganz ,  Adrian Blaser ,  Christoph Hannes Hoser ,  Horst Josef Fischer ,  Bodo Quint

Inventor： Matthias Wesselmann ,  Hans Lang ,  Susanne Pfenninger-Ganz ,  Adrian Blaser ,  Christoph Hannes Hoser ,  Horst Josef Fischer ,  Bodo Quint

IPC: A61M25/10

CPC classification number: A61M25/1011 ,  A61M25/1034 ,  A61M25/104 ,  A61M2025/1013 ,  A61M2025/1084

Abstract: A balloon catheter, including an outer shaft with a distal end and a fluid line, an inner part located distal anterior to its distal end, as well as a balloon that can be inflated under the influence of a fluid that has been pressurized by the fluid line, that is fastened fluid-tight onto the distal end section of the outer shaft with a first fastening zone at its proximal end, and fluid-tight onto inner part with a second fastening zone at its distal end, whereby the balloon, on at least one of its two ends is designed without cone and with essentially unvarying thin wall thickness, the balloon is provided on at least one of its two ends with respectively one twist anterior to its fastening zone, and a second balloon is placed above the first balloon and is also provided with a twist on at least one of its two ends anterior to the fastening zone, that is directed in the opposite direction of the twist of the first balloon end that is positioned underneath.

Abstract translation: 包括具有远端和流体管线的外轴的气囊导管，位于其远端前方远端的内部部分，以及可在被流体加压的流体的影响下膨胀的气囊 线，其被紧密地紧固到外轴的远端部分上，在其近端具有第一紧固区域，并且在其远端处具有第二紧固区域的流体密封到内部部分，由此气囊 其两端中的至少一端被设计成没有锥体并且具有基本上不变的薄壁厚度，所述气囊在其两端中的至少一个上设置有分别在其紧固区之前的一个扭曲，并且第二气球被放置在第一气球的上方 并且还在其紧固区域之前的两个端部中的至少一个上具有扭转，该扭转部分沿着位于下方的第一气囊端部的扭转的相反方向。

公开(公告)号：US5364846A

公开(公告)日：1994-11-15

申请号：US156995

申请日：1993-11-24

Applicant: Hans Lang ,  Christoph Naumann ,  Ruth Raiss ,  Osamu Komiyama ,  Yoshiko Terui

Inventor： Hans Lang ,  Christoph Naumann ,  Ruth Raiss ,  Osamu Komiyama ,  Yoshiko Terui

IPC: A61K31/66 ,  A61K31/675 ,  A61P3/00 ,  A61P19/10 ,  A61P43/00 ,  C07F9/38 ,  C07F9/40

CPC classification number: C07F9/3873 ,  C07F9/3821 ,  C07F9/4012 ,  C07F9/405

Abstract: Substituted aminoethane-1,1-bisphosphonic acids and aminoethane-1,1-alkylphosphinophosphonic acids, processes for their preparation and use thereofThe invention relates to compounds of the formula I ##STR1## in which R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are a hydrogen atom or (C.sub.5 -C.sub.5)-alkyl, m is the integer 0 or 1, x is (C.sub.1 -C.sub.10)-alkyl, mono- or polysubstituted, a 5- or 6-membered ring having one nitrogen atom and optionally a further nitrogen or oxygen atom; aryl having 6 or 10 carbon atoms, which can be substituted; or cycloalkyl, to processes for the preparation of the compound of the formula I; to pharmaceuticals, and to their use for the treatment of osteoporosis and degenerative joint diseases.

Abstract translation: 取代的氨基乙烷-1,1-二膦酸和氨基乙烷-1,1-烷基膦磷酸，其制备方法和用途本发明涉及式I氢原子或（C5-C5） - 烷基的化合物，m是整数 0或1，x是（C1-C10） - 烷基，单或多取代的具有一个氮原子和任选另外的氮或氧原子的5-或6-元环; 具有6或10个碳原子的芳基，其可被取代; 或环烷基，用于制备式I化合物的方法; 用于制药，以及用于治疗骨质疏松症和退行性关节疾病。

公开(公告)号：US4779352A

公开(公告)日：1988-10-25

申请号：US66791

申请日：1987-06-25

Applicant: Hans Lang

Inventor： Hans Lang

IPC: G01N19/04 ,  G01N33/00 ,  G01B7/06

CPC classification number: G01N19/04 ,  G01N2033/0083

Abstract: A method and an apparatus are provided for testing final coating layer thicknesses on motor vehicle bodies by means of measuring probes moved along a body by way of automatic manipulators. A measuring probe (20), disposed in a guide member suspended on gimbals, is attached to the surface of the body by means of a suction cup (15), an inner stop ring (16) and a spring (21) which cooperate to ensure that the measuring probe is applied with a specific pressure.

Abstract translation: 提供了一种通过借助于通过自动操纵器沿身体移动的测量探头来测试机动车体上的最终涂层厚度的方法和装置。 设置在悬挂在万向架上的引导构件中的测量探头（20）通过吸盘（15），内止挡环（16）和弹簧（21）附接到主体的表面 确保测量探头被施加特定的压力。

公开(公告)号：US4447255A

公开(公告)日：1984-05-08

申请号：US965263

申请日：1978-12-01

Applicant: Eberhard P. Schott ,  Hans Lang

Inventor： Eberhard P. Schott ,  Hans Lang

IPC: A01N43/40 ,  A01N57/20 ,  A01N57/22 ,  A01P21/00 ,  A01N57/12

CPC classification number: A01N57/20 ,  A01N57/22

Abstract: New agents for regulating plant growth, especially for reducing the height of plants, containing a mixture of a quaternary substituted thianium or ammonium salt and a phosphonic acid derivative.

Abstract translation: 用于调节植物生长的新试剂，特别是用于降低植物的高度，其含有季铵取代的硫鎓或铵盐和膦酸衍生物的混合物。

公开(公告)号：US09770575B2

公开(公告)日：2017-09-26

申请号：US13283050

申请日：2011-10-27

Applicant: Matthias Wesselmann ,  Tobias Brunner ,  Hans Lang

Inventor： Matthias Wesselmann ,  Tobias Brunner ,  Hans Lang

IPC: A61M25/10 ,  A61F2/958 ,  A61F2/966

CPC classification number: A61M25/1006 ,  A61F2/958 ,  A61F2/966 ,  A61M2025/105 ,  A61M2025/1061 ,  A61M2025/1068 ,  A61M2025/1081 ,  A61M2025/1093

Abstract: A balloon catheter, in particular for delivering medicaments, stents or medicament-coated stents in the region of a stenosis, comprising an outer shaft (4) an inner shaft (6), and a balloon (7) at the distal catheter end, which balloon is dilatable by a feedable pressure fluid and which is attached with its proximal end (8) to the outer shaft (4) and with its distal end (9) to the inner shaft (6) which protrudes the outer shaft (4) in the distal direction, and a cover sheath (15) which is seated in a covering position over the contracted balloon (7) and is displaceably guided on the outer shaft (4) and which is displaceable on the outer shaft (4) in the proximal direction via its front opening (17) by the dilating balloon (7) while continuously releasing the same from distal to proximal.

公开(公告)号：US08512369B2

公开(公告)日：2013-08-20

申请号：US13090520

申请日：2011-04-20

Applicant: Matthias Wesselmann ,  Hans Lang ,  Susanne Pfenninger-Ganz

Inventor： Matthias Wesselmann ,  Hans Lang ,  Susanne Pfenninger-Ganz

IPC: A61M29/00

CPC classification number: A61M25/1027 ,  A61F2/958 ,  A61F2/962 ,  A61M25/1006 ,  A61M2025/0004 ,  A61M2025/0175

Abstract: A combined rolling membrane-balloon catheter, in particular for expanding stenoses in bodily vessels, including: an outer shaft (1) and an inner shaft (4) which is axially displaceable therein, an intermediate shaft (7) situated between the inner and outer shafts (4, 1) which is likewise axially displaceable, a rolling membrane (12) which is attached in a pressure-tight manner between the distal end (2) of the outer shaft (1) and the distal end (11) of the inner shaft (4), and which may be displaced between a passive position within the outer shaft (1) and an active position which is distally expanded from the outer shaft (1) by the action of pressure, and a dilatable balloon (14) which is attached in a pressure-tight manner between the distal end (11) of the inner shaft (4) and the distal end of the intermediate shaft (7), and which may be displaced between a passive position within the outer shaft (1) and proximally in front of the rolling membrane (12), and an active position which is distally expanded from the outer shaft (1), within the rolling membrane (12), by the action of pressure.

Abstract translation: 组合的滚动膜 - 气囊导管，特别是用于在身体血管中扩张狭窄，包括：外轴（1）和可在其内轴向移位的内轴（4），位于内外的中间轴（7） 同轴可移动的轴（4,1），在外轴（1）的远端（2）与外轴（1）的远端（11）之间以压力方式连接的滚动膜（12） 内轴（4），并且其可以在外轴（1）内的被动位置和通过压力作用从外轴（1）远端膨胀的活动位置之间移位，以及可膨胀气囊（14） 其在内轴（4）的远端（11）和中间轴（7）的远端之间以压力方式连接，并且可以在外轴（1）内的被动位置 ）和近侧在轧制膜（12）的前方，以及活动位置 通过压力的作用在所述滚动膜（12）内远离所述外轴（1）远端膨胀。

公开(公告)号：US20120116490A1

公开(公告)日：2012-05-10

申请号：US13283050

申请日：2011-10-27

Applicant: Matthias Wesselmann ,  Tobias Brunner ,  Hans Lang

Inventor： Matthias Wesselmann ,  Tobias Brunner ,  Hans Lang

IPC: A61F2/84 ,  A61M25/10

CPC classification number: A61M25/1006 ,  A61F2/958 ,  A61F2/966 ,  A61M2025/105 ,  A61M2025/1061 ,  A61M2025/1068 ,  A61M2025/1081 ,  A61M2025/1093

Abstract: A balloon catheter, in particular for delivering medicaments, stents or medicament-coated stents in the region of a stenosis, comprising an outer shaft (4) an inner shaft (6), and a balloon (7) at the distal catheter end, which balloon is dilatable by a feedable pressure fluid and which is attached with its proximal end (8) to the outer shaft (4) and with its distal end (9) to the inner shaft (6) which protrudes the outer shaft (4) in the distal direction, and a cover sheath (15) which is seated in a covering position over the contracted balloon (7) and is displaceably guided on the outer shaft (4) and which is displaceable on the outer shaft (4) in the proximal direction via its front opening (17) by the dilating balloon (7) while continuously releasing the same from distal to proximal.

Abstract translation: 气囊导管，特别是用于在狭窄区域内递送药物，支架或药物涂层的支架，其包括外轴（4），内轴（6）和远端导管端的气囊（7），其中 球囊由可进给压力流体膨胀，并且其近端（8）附接到外轴（4），并且其远端（9）附接到突出外轴（4）的内轴（6） 远端方向，以及覆盖护套（15），其位于收缩气囊（7）上方的覆盖位置，并且在外轴（4）上被可移位地引导，并且其可在近侧的外轴（4）上移位 方向通过其前开口（17）通过扩张气囊（7）连续地从远端到近端释放。

公开(公告)号：US20110270296A1

公开(公告)日：2011-11-03

申请号：US13090520

申请日：2011-04-20

Applicant: Matthias Wesselmann ,  Hans Lang ,  Susanne Pfenninger-Ganz

Inventor： Matthias Wesselmann ,  Hans Lang ,  Susanne Pfenninger-Ganz

IPC: A61M29/02 ,  B65H69/02

CPC classification number: A61M25/1027 ,  A61F2/958 ,  A61F2/962 ,  A61M25/1006 ,  A61M2025/0004 ,  A61M2025/0175

Abstract: A combined rolling membrane-balloon catheter, in particular for expanding stenoses in bodily vessels, including: an outer shaft (1) and an inner shaft (4) which is axially displaceable therein, an intermediate shaft (7) situated between the inner and outer shafts (4, 1) which is likewise axially displaceable, a rolling membrane (12) which is attached in a pressure-tight manner between the distal end (2) of the outer shaft (1) and the distal end (11) of the inner shaft (4), and which may be displaced between a passive position within the outer shaft (1) and an active position which is distally expanded from the outer shaft (1) by the action of pressure, and a dilatable balloon (14) which is attached in a pressure-tight manner between the distal end (11) of the inner shaft (4) and the distal end of the intermediate shaft (7), and which may be displaced between a passive position within the outer shaft (1) and proximally in front of the rolling membrane (12), and an active position which is distally expanded from the outer shaft (1), within the rolling membrane (12), by the action of pressure.

Abstract translation: 组合的滚动膜 - 气囊导管，特别是用于在身体血管中扩张狭窄，包括：外轴（1）和可在其内轴向移位的内轴（4），位于内外的中间轴（7） 同轴可移动的轴（4,1），在外轴（1）的远端（2）与外轴（1）的远端（11）之间以压力方式连接的滚动膜（12） 内轴（4），并且其可以在外轴（1）内的被动位置和通过压力作用从外轴（1）远端膨胀的活动位置之间移位，以及可膨胀气囊（14） 其在内轴（4）的远端（11）和中间轴（7）的远端之间以压力方式连接，并且可以在外轴（1）内的被动位置 ）和近侧在轧制膜（12）的前方，以及活动位置 通过压力的作用在所述滚动膜（12）内远离所述外轴（1）远端膨胀。