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公开(公告)号：US5625079A
公开(公告)日：1997-04-29
申请号：US462377
申请日：1995-06-05
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/00
CPC分类号： C07D493/04 , A01N1/02 , A01N1/0205 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Synthesis of 4,8-dialkyl-4'-bromomethyl-5'-methylpsoralen and 4,8-dialkyl-5'-bromomethyl-4'-methylpsoralen compounds useful as intermediates.
摘要翻译： 用作中间体的4,8-二烷基-4'-溴甲基-5'-甲基睾丸激素和4,8-二烷基-5'-溴甲基-4'-甲基脯氨酸化合物的合成。
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公开(公告)号：US5585503A
公开(公告)日：1996-12-17
申请号：US455053
申请日：1995-05-31
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K35/14 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/00
CPC分类号： C07D493/04 , A01N1/0215 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
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公开(公告)号：US5399719A
公开(公告)日：1995-03-21
申请号：US83459
申请日：1993-06-28
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K35/14 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/00
CPC分类号： C07D493/04 , A01N1/0215 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
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4.发明授权Method for inactivating pathogens in blood using photoactivation of 4'-primary amino-substituted psoralens 失效使用4'-伯氨基取代的补骨脂素的光活化来灭活血液中的病原体的方法
公开(公告)号：US5593823A
公开(公告)日：1997-01-14
申请号：US337987
申请日：1994-11-14
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K41/00 , A61L2/00 , C07D493/04 , C12N7/06
CPC分类号： C07D493/04 , A01N1/0215 , A01N1/0294 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion.
摘要翻译： 合成补骨脂素化合物，其在补骨脂素的4,4'，5'和8位上具有取代，其允许增强与病原体核酸的结合。 描述了更高的补骨脂素结合水平和较低的致突变性，导致血液制品中病原体的更安全，更有效和可靠的失活。 本发明考虑使用新的补骨脂素的灭活方法，其不损害用于输血的血液制品的功能。
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公开(公告)号：US5578736A
公开(公告)日：1996-11-26
申请号：US456205
申请日：1995-05-31
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K35/14 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/02
CPC分类号： C07D493/04 , A01N1/0215 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
摘要翻译： 合成补骨脂素化合物组合物，其在补骨脂素的4,4'，5'和8位上具有取代，其仍然允许它们与病原体的核酸结合。 激活这些结合的补骨脂素的反应条件导致与核酸的共价交联，从而使病原体灭活。 更高的补骨脂素结合水平和较低的致突变性导致更安全，更有效和可靠的病原体失活。 除了补骨脂素组合物之外，本发明考虑使用新的补骨脂素的灭活方法。
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公开(公告)号：US5556993A
公开(公告)日：1996-09-17
申请号：US465495
申请日：1995-06-05
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/00
CPC分类号： C07D493/04 , A01N1/02 , A01N1/0205 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compounds are synthesized which have substitutions on the 4,4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion.
摘要翻译： 合成补骨脂素化合物，其在补骨脂素的4,4'，5'和8位上具有取代，其允许增强与病原体核酸的结合。 描述了更高的补骨脂素结合水平和较低的致突变性，导致血液制品中病原体的更安全，更有效和可靠的失活。 本发明考虑使用新的补骨脂素的灭活方法，其不损害用于输血的血液制品的功能。
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