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公开(公告)号：US09096585B2
公开(公告)日：2015-08-04
申请号：US13700049
申请日：2011-05-31
IPC分类号： A61K31/41 , A61K31/515 , A61K31/535 , C07D413/14 , A61K31/4245 , C07D413/10 , C07D413/12 , A61K31/55 , A61K31/5377
CPC分类号： C07D413/14 , A61K31/4245 , A61K31/5377 , A61K31/55 , C07D413/10 , C07D413/12 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Described herein are Compounds, compositions comprising such Compounds, and the use of such Compounds and compositions as anti-viral agents. In one aspect, provided herein are methods of inhibiting viral replication using Compounds described herein or compositions thereof. In another aspect, provided herein are methods for preventing a symptom of a viral infection using a Compound, or a composition thereof. In another aspect, provided herein are methods of treating and/or managing viral infection using a compound or a composition thereof.
摘要翻译： 本文描述的是化合物，包含这些化合物的组合物，以及这些化合物和组合物作为抗病毒剂的用途。 一方面，本文提供了使用本文所述的化合物或其组合物来抑制病毒复制的方法。 在另一方面，本文提供了使用化合物或其组合物预防病毒感染症状的方法。 另一方面，本文提供了使用化合物或其组合物治疗和/或控制病毒感染的方法。
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2.发明授权Compounds that modulate negative-sense, single-stranded RNA virus replication and uses thereof 有权调节负义单链RNA病毒复制的化合物及其用途公开(公告)号：US08629283B2
公开(公告)日：2014-01-14
申请号：US12921077
申请日：2009-03-06
IPC分类号： C07D271/113
CPC分类号： C07D271/113 , A61K31/00 , A61K31/4245
摘要： The present invention relates to compounds that modulate the replication of negative-sense, single-stranded RNA viruses, such as influenza virus, and the use of such compounds. The invention relates to methods for increasing the titer of negative-sense, single-stranded RNA viruses, such as influenza virus, in substrates for virus propagation (e.g., tissue culture). The invention also relates to the use of compounds that decrease virus replication as antiviral agents. The invention further relates to methods for identifying compounds that modulate the replication of negative-sense, single-stranded RNA viruses, in particular, influenza virus.
摘要翻译： 本发明涉及调节负义单链RNA病毒如流感病毒复制的化合物，以及这些化合物的用途。 本发明涉及用于在用于病毒繁殖（例如组织培养）的底物中增加负义的单链RNA病毒如流感病毒的滴度的方法。 本发明还涉及减少病毒复制作为抗病毒剂的化合物的用途。 本发明还涉及用于鉴定调节负义的单链RNA病毒，特别是流感病毒的复制的化合物的方法。
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3.发明申请COMPOUNDS THAT MODULATE NEGATIVE-SENSE, SINGLE-STRANDED RNA VIRUS REPLICATION AND USES THEREOF 有权调节负面感觉，单链RNA病毒复制及其用途的化合物公开(公告)号：US20110105423A1
公开(公告)日：2011-05-05
申请号：US12921077
申请日：2009-03-06
IPC分类号： A61K31/4245 , C12N7/00 , C12N7/06 , C12Q1/70 , C40B30/06 , A61K31/5377 , A61K31/55 , A61K31/427 , A61K31/426 , A61K31/365 , A61K31/7048 , A61K31/585 , A61K31/44 , A61K31/40 , A61K31/352 , A61K31/496 , A61P31/14 , A61P31/16
CPC分类号： C07D271/113 , A61K31/00 , A61K31/4245
摘要： The present invention relates to compounds that modulate the replication of negative-sense, single-stranded RNA viruses, such as influenza virus, and the use of such compounds. The invention relates to methods for increasing the titer of negative-sense, single-stranded RNA viruses, such as influenza virus, in substrates for virus propagation (e.g., tissue culture). The invention also relates to the use of compounds that decrease virus replication as antiviral agents. The invention further relates to methods for identifying compounds that modulate the replication of negative-sense, single-stranded RNA viruses, in particular, influenza virus.
摘要翻译： 本发明涉及调节负义单链RNA病毒如流感病毒复制的化合物，以及这些化合物的用途。 本发明涉及用于在用于病毒繁殖（例如组织培养）的底物中增加负义的单链RNA病毒如流感病毒的滴度的方法。 本发明还涉及减少病毒复制作为抗病毒剂的化合物的用途。 本发明还涉及用于鉴定调节负义的单链RNA病毒，特别是流感病毒的复制的化合物的方法。
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公开(公告)号：US20130137678A1
公开(公告)日：2013-05-30
申请号：US13700049
申请日：2011-05-31
IPC分类号： C07D413/14 , C07D413/10 , C07D413/12
CPC分类号： C07D413/14 , A61K31/4245 , A61K31/5377 , A61K31/55 , C07D413/10 , C07D413/12 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Described herein are Compounds, compositions comprising such Compounds, and the use of such Compounds and compositions as anti-viral agents. In one aspect, provided herein are methods of inhibiting viral replication using Compounds described herein or compositions thereof. In another aspect, provided herein are methods for preventing a symptom of a viral infection using a Compound, or a composition thereof. In another aspect, provided herein are methods of treating and/or managing viral infection using a compound or a composition thereof.
摘要翻译： 本文描述的是化合物，包含这些化合物的组合物，以及这些化合物和组合物作为抗病毒剂的用途。 一方面，本文提供了使用本文所述的化合物或其组合物来抑制病毒复制的方法。 在另一方面，本文提供了使用化合物或其组合物预防病毒感染症状的方法。 另一方面，本文提供了使用化合物或其组合物治疗和/或控制病毒感染的方法。
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