公开(公告)号：US20130045934A1

公开(公告)日：2013-02-21

申请号：US13583367

申请日：2011-03-03

申请人： Hideyasu Tsuji ,  Yasuhiro Tsuji ,  Toru Oka ,  Haruka Miyao ,  Denny Liauw

发明人： Hideyasu Tsuji ,  Yasuhiro Tsuji ,  Toru Oka ,  Haruka Miyao ,  Denny Liauw

IPC分类号： A61K31/7024 ,  A61P37/08 ,  A23L1/28 ,  A61P25/20 ,  A61P35/04 ,  A61P35/00 ,  A61K31/235 ,  A61P3/08

CPC分类号： B01D11/0265 ,  B01D11/0211

摘要： The present invention provides an extraction method that either does not use emulsifiers, organic solvents, and the like or can reduce the amount used of emulsifiers, organic solvents, and the like. In addition, the extraction method of present invention can also efficiently extract various components from various materials to be extracted, and can highly maintain potency and the like of the extracted components, in particular if the components are active agents. Furthermore, the extraction method of present invention has excellent safety. The extraction method of present invention is achieved by bringing materials to be extracted into contact with liquid containing ultra fine bubbles for extraction treatment. The ultra fine bubbles utilized during the extraction process preferably have a mode diameter of 500 nm or smaller and a concentration of 1,000,000 or more per 1 ml of liquid.

摘要翻译： 本发明提供了不使用乳化剂，有机溶剂等或可以减少乳化剂，有机溶剂等使用量的提取方法。 此外，本发明的提取方法还可以从各种待提取的材料中有效地提取各种成分，并且可以高度保持提取的组分的效力等，特别是如果组分是活性剂。 此外，本发明的提取方法具有优异的安全性。 本发明的提取方法是通过将待提取的材料与含有超细气泡的液体接触进行萃取处理来实现的。 在提取过程中使用的超细小气泡优选具有500nm或更小的模式直径和每1ml液体1,000,000或更多的浓度。

公开(公告)号：US20120128749A1

公开(公告)日：2012-05-24

申请号：US13361150

申请日：2012-01-30

申请人： Hideyasu Tsuji ,  Yasuhiro Tsuji ,  Toru Oka ,  Shigeru Sugi ,  Masumi Torii ,  Haruka Miyao ,  Yoshimitsu Nakayama ,  Tomoyuki Torii ,  Masahito Mori

发明人： Hideyasu Tsuji ,  Yasuhiro Tsuji ,  Toru Oka ,  Shigeru Sugi ,  Masumi Torii ,  Haruka Miyao ,  Yoshimitsu Nakayama ,  Tomoyuki Torii ,  Masahito Mori

IPC分类号： A01N25/02 ,  A01P1/00 ,  A01P3/00 ,  A01P17/00 ,  A01P7/04 ,  A61P31/10 ,  A61K8/02 ,  B08B7/02 ,  A61K9/14 ,  A61P31/04 ,  B82Y40/00 ,  B82Y5/00 ,  B82Y99/00

CPC分类号： B01J13/0052 ,  A01N25/04 ,  A01N25/34 ,  A23L2/54 ,  A01N27/00 ,  A01N31/06 ,  A01N43/78 ,  A01N65/26 ,  A01N65/36 ,  A01N65/00

摘要： Disclosed are: a composition which enables the more effective development of the efficacy of a water-soluble drug in a solution containing the drug; and a dispersion in which a hydrophobic drug can be dispersed stably without requiring the use of any surfactant. Specifically disclosed are: a composition comprising ultra-fine bubbles having a mode particle size of 500 nm or less, a drug and water; and a process for producing a composition comprising ultra-fine bubbles having a mode particle size of 500 nm or less, a drug and water, which utilizes an ultra-fine bubble generation apparatus.

摘要翻译： 公开了一种组合物，其能够更有效地开发含有药物的溶液中的水溶性药物的功效; 以及其中疏水性药物可以稳定分散而不需要使用任何表面活性剂的分散体。 具体公开的是包含模粒径为500nm以下的超细小气泡，药物和水的组合物; 以及利用超微细气泡产生装置制造包含模式粒径为500nm以下的超细小气泡，药物和水的组合物的方法。