公开(公告)号：US20130045934A1

公开(公告)日：2013-02-21

申请号：US13583367

申请日：2011-03-03

申请人： Hideyasu Tsuji ,  Yasuhiro Tsuji ,  Toru Oka ,  Haruka Miyao ,  Denny Liauw

发明人： Hideyasu Tsuji ,  Yasuhiro Tsuji ,  Toru Oka ,  Haruka Miyao ,  Denny Liauw

IPC分类号： A61K31/7024 ,  A61P37/08 ,  A23L1/28 ,  A61P25/20 ,  A61P35/04 ,  A61P35/00 ,  A61K31/235 ,  A61P3/08

CPC分类号： B01D11/0265 ,  B01D11/0211

摘要： The present invention provides an extraction method that either does not use emulsifiers, organic solvents, and the like or can reduce the amount used of emulsifiers, organic solvents, and the like. In addition, the extraction method of present invention can also efficiently extract various components from various materials to be extracted, and can highly maintain potency and the like of the extracted components, in particular if the components are active agents. Furthermore, the extraction method of present invention has excellent safety. The extraction method of present invention is achieved by bringing materials to be extracted into contact with liquid containing ultra fine bubbles for extraction treatment. The ultra fine bubbles utilized during the extraction process preferably have a mode diameter of 500 nm or smaller and a concentration of 1,000,000 or more per 1 ml of liquid.

摘要翻译： 本发明提供了不使用乳化剂，有机溶剂等或可以减少乳化剂，有机溶剂等使用量的提取方法。 此外，本发明的提取方法还可以从各种待提取的材料中有效地提取各种成分，并且可以高度保持提取的组分的效力等，特别是如果组分是活性剂。 此外，本发明的提取方法具有优异的安全性。 本发明的提取方法是通过将待提取的材料与含有超细气泡的液体接触进行萃取处理来实现的。 在提取过程中使用的超细小气泡优选具有500nm或更小的模式直径和每1ml液体1,000,000或更多的浓度。

公开(公告)号：US20120128749A1

公开(公告)日：2012-05-24

申请号：US13361150

申请日：2012-01-30

申请人： Hideyasu Tsuji ,  Yasuhiro Tsuji ,  Toru Oka ,  Shigeru Sugi ,  Masumi Torii ,  Haruka Miyao ,  Yoshimitsu Nakayama ,  Tomoyuki Torii ,  Masahito Mori

发明人： Hideyasu Tsuji ,  Yasuhiro Tsuji ,  Toru Oka ,  Shigeru Sugi ,  Masumi Torii ,  Haruka Miyao ,  Yoshimitsu Nakayama ,  Tomoyuki Torii ,  Masahito Mori

IPC分类号： A01N25/02 ,  A01P1/00 ,  A01P3/00 ,  A01P17/00 ,  A01P7/04 ,  A61P31/10 ,  A61K8/02 ,  B08B7/02 ,  A61K9/14 ,  A61P31/04 ,  B82Y40/00 ,  B82Y5/00 ,  B82Y99/00

CPC分类号： B01J13/0052 ,  A01N25/04 ,  A01N25/34 ,  A23L2/54 ,  A01N27/00 ,  A01N31/06 ,  A01N43/78 ,  A01N65/26 ,  A01N65/36 ,  A01N65/00

摘要： Disclosed are: a composition which enables the more effective development of the efficacy of a water-soluble drug in a solution containing the drug; and a dispersion in which a hydrophobic drug can be dispersed stably without requiring the use of any surfactant. Specifically disclosed are: a composition comprising ultra-fine bubbles having a mode particle size of 500 nm or less, a drug and water; and a process for producing a composition comprising ultra-fine bubbles having a mode particle size of 500 nm or less, a drug and water, which utilizes an ultra-fine bubble generation apparatus.

摘要翻译： 公开了一种组合物，其能够更有效地开发含有药物的溶液中的水溶性药物的功效; 以及其中疏水性药物可以稳定分散而不需要使用任何表面活性剂的分散体。 具体公开的是包含模粒径为500nm以下的超细小气泡，药物和水的组合物; 以及利用超微细气泡产生装置制造包含模式粒径为500nm以下的超细小气泡，药物和水的组合物的方法。

公开(公告)号：US08186653B2

公开(公告)日：2012-05-29

申请号：US12227524

申请日：2007-05-21

申请人： Hideyasu Tsuji

发明人： Hideyasu Tsuji

IPC分类号： B01F3/04

CPC分类号： B01F3/0446 ,  B01F5/0068 ,  B01F5/106 ,  B01F5/12 ,  B01F13/103 ,  B01F2003/04858

摘要： This invention provides a fine bubble generating apparatus which can efficiently generate fine bubbles on the nanometer level. This apparatus includes a cylindrical member having a cylindrical inner peripheral surface, a first end wall member configured to close one end of the cylindrical member, and a second end wall member configured to close the other end of the cylindrical member. The cylindrical member and the first and second end wall members define a fluid swirling chamber. The cylindrical member has a fluid inlet hole at a position close to the second end wall member to supply a gas-liquid mixed fluid in the tangential direction of the peripheral surface of the fluid swirling chamber. The second end wall member has a fluid outlet hole extending therethrough along the center axis of the inner peripheral surface of the fluid swirling chamber. The gas-liquid mixed fluid is introduced into the fluid swirling chamber at a position close to the second end wall member. Most of the fluid is directed toward the first end wall member while swirling along the inner peripheral surface of the fluid swirling chamber, reversed from the first end wall member toward the second end wall member and discharged through the fluid outlet hole.

摘要翻译： 本发明提供一种能够有效地在纳米级产生细小气泡的细小气泡发生装置。 该装置包括具有圆柱形内周面的圆柱形构件，构造成封闭圆柱形构件的一端的第一端壁构件和用于封闭圆柱形构件的另一端的第二端壁构件。 圆柱形构件和第一和第二端壁构件限定流体旋转室。 圆柱形构件在靠近第二端壁构件的位置处具有流体入口孔，以在流体旋转室的外周表面的切线方向上供应气液混合流体。 第二端壁构件具有沿着流体旋转室的内周表面的中心轴线延伸穿过的流体出口孔。 气液混合流体在靠近第二端壁构件的位置处被引入到流体旋转室中。 大部分流体被引导朝向第一端壁构件，同时沿着流体旋转室的内周表面旋转，从第一端壁构件朝向第二端壁构件反向并且通过流体出口孔排出。

公开(公告)号：US08523151B2

公开(公告)日：2013-09-03

申请号：US13462243

申请日：2012-05-02

申请人： Hideyasu Tsuji

发明人： Hideyasu Tsuji

IPC分类号： B01F3/04

CPC分类号： B01F3/0446 ,  B01F5/0068 ,  B01F5/106 ,  B01F5/12 ,  B01F13/103 ,  B01F2003/04858

摘要： A fine bubble generating apparatus that efficiently generates fine bubbles on the nanometer level. A cylindrical member has a cylindrical inner peripheral surface, a first end wall member closing one end of the cylindrical member, and a second end wall member closing the other end of the cylindrical member. The cylindrical member and the first and second end wall members define a fluid swirling chamber. The cylindrical member has a fluid inlet hole at a position close to the second end wall member to supply a gas-liquid mixed fluid in the tangential direction of the peripheral surface of the fluid swirling chamber. The second end wall member has a fluid outlet hole extending therethrough along the center axis of the inner peripheral surface of the fluid swirling chamber. The gas-liquid mixed fluid is introduced into the fluid swirling chamber at a position close to the second end wall member.

摘要翻译： 一种在纳米级有效地产生微小气泡的微小气泡发生装置。 圆柱形构件具有圆柱形内周表面，封闭圆柱形构件的一端的第一端壁构件和闭合圆柱形构件的另一端的第二端壁构件。 圆柱形构件和第一和第二端壁构件限定流体旋转室。 圆柱形构件在靠近第二端壁构件的位置处具有流体入口孔，以在流体旋转室的外周表面的切线方向上供应气液混合流体。 第二端壁构件具有沿着流体旋转室的内周表面的中心轴线延伸穿过的流体出口孔。 气液混合流体在靠近第二端壁构件的位置处被引入到流体旋转室中。

公开(公告)号：US20090117241A1

公开(公告)日：2009-05-07

申请号：US12227524

申请日：2007-05-21

申请人： Hideyasu Tsuji

发明人： Hideyasu Tsuji

IPC分类号： B01F3/04 ,  B02B1/04 ,  A21D6/00 ,  C02F3/12 ,  B05B7/30

CPC分类号： B01F3/0446 ,  B01F5/0068 ,  B01F5/106 ,  B01F5/12 ,  B01F13/103 ,  B01F2003/04858

摘要： This invention provides a fine bubble generating apparatus which can efficiently generate fine bubbles on the nanometer level. This apparatus comprises a cylindrical member (40) having a cylindrical inner peripheral surface, a first end wall member (42) configured to close one end of the cylindrical member, and a second end wall member (44) configured to close the other end of the cylindrical member. The cylindrical member (40) and the first and second end wall members (42) and (44) define a fluid swirling chamber (46). The cylindrical member has a fluid inlet hole (48) at a position close to the second end wall member (44) to supply a gas-liquid mixed fluid in the tangential direction of the peripheral surface of the fluid swirling chamber (46). The second end wall member has a fluid outlet hole (50) extending therethrough along the center axis of the inner peripheral surface of the fluid swirling chamber. The gas-liquid mixed fluid is introduced into the fluid swirling chamber at a position close to the second end wall member. Most of the fluid is directed toward the first end wall member while swirling along the inner peripheral surface of the fluid swirling chamber, reversed from the first end wall member toward the second end wall member and discharged through the fluid outlet hole.

摘要翻译： 本发明提供一种能够有效地在纳米级产生细小气泡的细小气泡发生装置。 该装置包括具有圆柱形内周面的圆柱形构件（40），构造成封闭圆柱形构件的一端的第一端壁构件（42）和用于封闭圆柱形构件的另一端的第二端壁构件（44） 圆柱形构件。 圆柱形构件（40）和第一和第二端壁构件（42）和（44）限定流体旋转室（46）。 所述圆筒形构件在靠近所述第二端壁构件（44）的位置处具有流体入口孔（48），以在所述流体旋转室（46）的外周表面的切线方向上供应气液混合流体。 第二端壁构件具有沿着流体旋转室的内周面的中心轴线延伸穿过的流体出口孔（50）。 气液混合流体在靠近第二端壁构件的位置处被引入到流体旋转室中。 大部分流体被引导朝向第一端壁构件，同时沿着流体旋转室的内周表面旋转，从第一端壁构件朝向第二端壁构件反向并且通过流体出口孔排出。