公开(公告)号：US06858727B2

公开(公告)日：2005-02-22

申请号：US10344267

申请日：2001-08-06

申请人： Cheol-hae Lee ,  Bong-jin Kim ,  Do-kyu Pyun ,  Won-jang Jeong ,  Jae-hak Kim ,  Hee-jung Chung ,  Hyun-jung Kwak ,  Eun-jung Kim ,  Shin-seup Song ,  Yong-ho Chung

发明人： Cheol-hae Lee ,  Bong-jin Kim ,  Do-kyu Pyun ,  Won-jang Jeong ,  Jae-hak Kim ,  Hee-jung Chung ,  Hyun-jung Kwak ,  Eun-jung Kim ,  Shin-seup Song ,  Yong-ho Chung

IPC分类号： C07D413/14 ,  C07D205/08 ,  C07D265/06 ,  C07D265/14 ,  C07D413/06 ,  C07D487/04 ,  C07D498/10 ,  C07F7/18 ,  C07F9/572 ,  C07F9/6561 ,  C07F9/568

CPC分类号： C07D413/06 ,  C07D205/08 ,  C07D265/06 ,  C07D265/14 ,  C07D487/04 ,  C07F9/65611 ,  Y02P20/55

摘要： There is disclosed an azetidinone compound of the formula (I): wherein R is hydrogen, or a hydroxy protecting group, R1 and R2 are each independently alkyl of 1-15 carbon atoms, benzyl or cyclized together with the carbon atom to which they are attached to form a 5 or 6-membered cyclic hydrocarbon or a heterocyclic radical having one or two hetero ring atoms, said hetero ring atoms being selected from the group consisting of O and S; R3 is lower alkyl or —COO(lower alkyl) R4 is phenyl, or phenyl substituted with halogen, lower alkoxy or nitro which is useful as a synthetic intermediate to the 1′β-methylcarbapenem-type antibacterial agent.

摘要翻译： 公开了式（I）的氮杂环丁酮化合物：其中R是氢或羟基保护基，R 1和R 2各自独立地是1-15个碳原子的烷基，或与它们所在的碳原子一起环化 连接以形成具有一个或两个杂环原子的5或6元环烃或杂环基团，所述杂环原子选自O和S; R3是低级烷基或-COO（低级烷基）R4是苯基，或被卤素，低级烷氧基或硝基取代的苯基，其可用作1'-二甲基碳青霉烯型抗菌剂的合成中间体。