公开(公告)号：US20130211133A1

公开(公告)日：2013-08-15

申请号：US13810145

申请日：2011-07-14

申请人： Joung Han Yim ,  Il Chan Kim ,  Sung Gu Lee ,  Dockyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Seung Jin Kim ,  Tai Kyoung Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park ,  Hye Yeon Koh ,  Mi Ra Park ,  Yu-Kyeong Park

发明人： Joung Han Yim ,  Il Chan Kim ,  Sung Gu Lee ,  Dockyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Seung Jin Kim ,  Tai Kyoung Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park ,  Hye Yeon Koh ,  Mi Ra Park ,  Yu-Kyeong Park

IPC分类号： C07C241/04

CPC分类号： C07C241/04 ,  C07C243/34

摘要： The present invention relates to a method for synthesizing ramalin, and more particularly to a method for synthesizing ramalin, which comprises allowing 2-hydrazinylphenol to react with L-glutamic acid having a protected carboxyl group at C-1 and a protected amino group at C-2, and a method for preventing decomposition of the ramalin. According to the present invention, ramalin having excellent antioxidant and anti-inflammatory activities can be synthesized in high yield, and thus can be produced in large amounts. In addition, ramalin can be stably maintained for a long period of time, and thus can be easily used for industrial purposes.

摘要翻译： 本发明涉及一种合成马来林蛋白的方法，更具体地说，涉及一种合成马马拉林的方法，该方法包括使2-肼基苯酚与C-1具有保护的羧基的L-谷氨酸和C的保护的氨基反应 -2，以及防止马马林分解的方法。 根据本发明，可以以高收率合成具有优异抗氧化和抗炎活性的马马林，因此可大量制造。 另外，马马龙可以长期稳定地维持，因此可以容易地用于工业目的。

公开(公告)号：US08865934B2

公开(公告)日：2014-10-21

申请号：US13810145

申请日：2011-07-14

申请人： Joung Han Yim ,  Il Chan Kim ,  Sung Gu Lee ,  Dockyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Seung Jin Kim ,  Tai Kyoung Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park ,  Hye Yeon Koh ,  Mi Ra Park ,  Yu-Kyeong Park

发明人： Joung Han Yim ,  Il Chan Kim ,  Sung Gu Lee ,  Dockyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Seung Jin Kim ,  Tai Kyoung Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park ,  Hye Yeon Koh ,  Mi Ra Park ,  Yu-Kyeong Park

IPC分类号： C07C241/00 ,  C07C243/00 ,  C07C249/00 ,  C07C241/04

CPC分类号： C07C241/04 ,  C07C243/34

摘要： The present invention relates to a method for synthesizing ramalin, and more particularly to a method for synthesizing ramalin, which comprises allowing 2-hydrazinylphenol to react with L-glutamic acid having a protected carboxyl group at C-1 and a protected amino group at C-2, and a method for preventing decomposition of the ramalin. According to the present invention, ramalin having excellent antioxidant and anti-inflammatory activities can be synthesized in high yield, and thus can be produced in large amounts. In addition, ramalin can be stably maintained for a long period of time, and thus can be easily used for industrial purposes.

摘要翻译： 本发明涉及一种合成马来林蛋白的方法，更具体地说，涉及一种合成马马拉林的方法，该方法包括使2-肼基苯酚与C-1具有保护的羧基的L-谷氨酸和C的保护的氨基反应 -2，以及防止马马林分解的方法。 根据本发明，可以以高收率合成具有优异抗氧化和抗炎活性的马马林，因此可大量制造。 另外，马马龙可以长期稳定地维持，因此可以容易地用于工业目的。

公开(公告)号：US20130116324A1

公开(公告)日：2013-05-09

申请号：US13701113

申请日：2011-06-02

申请人： Joung Han Yim ,  Il Chan Kim ,  Sung Gu Lee ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Sung Jin Kim ,  Tai Kyoung Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park ,  Suhkneung Pyo

发明人： Joung Han Yim ,  Il Chan Kim ,  Sung Gu Lee ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Sung Jin Kim ,  Tai Kyoung Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park ,  Suhkneung Pyo

IPC分类号： A61K31/198 ,  A61K45/06

CPC分类号： A61K31/198 ,  A61K31/45 ,  A61K45/06

摘要： The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen Ramalina terebrata, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-κB, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.

摘要翻译： 本发明涉及从南极地衣Ramalina terebrata分离的Ramalin的新用途（抗炎活性），更具体地涉及含有Ramalin作为活性成分的药物组合物。 本发明的Ramalin是衍生自天然材料的化合物，没有毒性或副作用，并且在转录期抑制诱导型一氧化氮合酶（iNOS）的表达，以显着抑制作为关键的一氧化氮（NO）的产生 炎症反应的介质。 此外，它抑制炎症介质NF-κB的活化，抑制p38 MAPK，ERK1 / 2和JNK信号通路，并抑制LPS受体TLR4的表达，提示Ramalin具有优异的抗炎作用。 因此，含有Ramalin的组合物可以有效地用于从根本上治疗或预防炎性疾病或免疫疾病，并缓解或缓解疾病的症状。

公开(公告)号：US08846750B2

公开(公告)日：2014-09-30

申请号：US13878196

申请日：2011-07-01

申请人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

发明人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

IPC分类号： A61K31/357 ,  C07D321/10 ,  A61K36/09 ,  A23L1/30 ,  C07D307/88 ,  C07D307/89 ,  C07D313/12

CPC分类号： C07D321/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/09 ,  C07D307/88 ,  C07D307/89 ,  C07D313/12 ,  A23V2200/3262 ,  A23V2200/332 ,  A23V2250/202

摘要： The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

公开(公告)号：US20130261174A1

公开(公告)日：2013-10-03

申请号：US13878196

申请日：2011-07-01

申请人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

发明人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

IPC分类号： C07D321/10

CPC分类号： C07D321/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/09 ,  C07D307/88 ,  C07D307/89 ,  C07D313/12 ,  A23V2200/3262 ,  A23V2200/332 ,  A23V2250/202

摘要： The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

摘要翻译： 本发明涉及用于预防或治疗糖尿病或肥胖症的药物和食品组合物，更具体地涉及用于预防或治疗糖尿病或肥胖症的药物组合物和功能性食品，其含有由分离的化合物合成的新化合物作为活性成分 从Stereocaulon alpinum的提取物。 本发明的新型化合物具有非常优异的PTP-1b（蛋白酪氨酸磷酸酶-1b）抑制活性，仅在蛋白酪氨酸磷酸酶中仅对PTP-1b起作用，并且是可有效预防或治疗糖尿病的实质性PTP-1b抑制剂 肥胖。