公开(公告)号：US08809578B2

公开(公告)日：2014-08-19

申请号：US13128586

申请日：2009-11-10

申请人： Joung Han Yim ,  Hong Kum Lee ,  Hari Datta Bhattarai ,  Paudel Babita ,  Il Chan Kim ,  Soon Gyu Hong ,  Doc Kyu Kim ,  Yoo Kyung Lee ,  Sung Gu Lee ,  Hyun Cheol Oh

发明人： Joung Han Yim ,  Hong Kum Lee ,  Hari Datta Bhattarai ,  Paudel Babita ,  Il Chan Kim ,  Soon Gyu Hong ,  Doc Kyu Kim ,  Yoo Kyung Lee ,  Sung Gu Lee ,  Hyun Cheol Oh

IPC分类号： A61Q19/02 ,  A61Q19/08 ,  A23L1/29 ,  A61K8/42 ,  C07C243/34

CPC分类号： C07C243/34 ,  A23L33/00 ,  A23V2002/00 ,  A61K8/42 ,  A61K2800/522 ,  A61Q19/02 ,  A61Q19/08 ,  A23V2200/02 ,  A23V2200/302

摘要： The present invention relates to a novel compound having excellent antioxidant activity, isolated from Ramalina terebrata, and more particularly to a novel compound, RAMALIN™, having excellent antioxidant activity, isolated from the Antarctic lichen Ramalina terebrata, a method for preparing the RAMALIN™, and a pharmaceutical composition, a functional food and a functional cosmetic composition, which contain the RAMALIN™ as an active ingredient. The RAMALIN™ according to the invention has significantly excellent antioxidant effects compared to commercially available antioxidants, and thus can be widely used in agents for treating oxidation-related diseases, anti-aging functional foods, functional cosmetic products for skin whitening and wrinkle reduction, etc.

摘要翻译： 本发明涉及一种从Ramalina terebrata分离得到的具有优异抗氧化活性的新型化合物，更具体地说涉及一种从南极地衣Ramalina terebrata分离得到的抗氧化活性优异的新型化合物RAMALIN TM，制备RAMALIN TM的方法， 以及含有RAMALIN TM作为活性成分的药物组合物，功能性食品和功能性化妆品组合物。 根据本发明的RAMALIN TM与市售抗氧化剂相比具有显着优异的抗氧化作用，因此可广泛用于治疗氧化相关疾病，抗衰老功能性食品，用于皮肤美白和皱纹减少的功能性化妆品等。 。

公开(公告)号：US08846750B2

公开(公告)日：2014-09-30

申请号：US13878196

申请日：2011-07-01

申请人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

发明人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

IPC分类号： A61K31/357 ,  C07D321/10 ,  A61K36/09 ,  A23L1/30 ,  C07D307/88 ,  C07D307/89 ,  C07D313/12

CPC分类号： C07D321/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/09 ,  C07D307/88 ,  C07D307/89 ,  C07D313/12 ,  A23V2200/3262 ,  A23V2200/332 ,  A23V2250/202

摘要： The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

公开(公告)号：US20130261174A1

公开(公告)日：2013-10-03

申请号：US13878196

申请日：2011-07-01

申请人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

发明人： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

IPC分类号： C07D321/10

CPC分类号： C07D321/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/09 ,  C07D307/88 ,  C07D307/89 ,  C07D313/12 ,  A23V2200/3262 ,  A23V2200/332 ,  A23V2250/202

摘要： The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

摘要翻译： 本发明涉及用于预防或治疗糖尿病或肥胖症的药物和食品组合物，更具体地涉及用于预防或治疗糖尿病或肥胖症的药物组合物和功能性食品，其含有由分离的化合物合成的新化合物作为活性成分 从Stereocaulon alpinum的提取物。 本发明的新型化合物具有非常优异的PTP-1b（蛋白酪氨酸磷酸酶-1b）抑制活性，仅在蛋白酪氨酸磷酸酶中仅对PTP-1b起作用，并且是可有效预防或治疗糖尿病的实质性PTP-1b抑制剂 肥胖。

公开(公告)号：US20110262374A1

公开(公告)日：2011-10-27

申请号：US13128586

申请日：2009-11-10

申请人： Joung Han Yim ,  Hong Kum Lee ,  Hari Datta Bhattarai ,  Paudel Babita ,  Il Chan Kim ,  Soon Gyu Hong ,  Doc Kyu Kim ,  Yoo Kyung Lee ,  Sung Gu Lee ,  Hyun Cheol Oh

发明人： Joung Han Yim ,  Hong Kum Lee ,  Hari Datta Bhattarai ,  Paudel Babita ,  Il Chan Kim ,  Soon Gyu Hong ,  Doc Kyu Kim ,  Yoo Kyung Lee ,  Sung Gu Lee ,  Hyun Cheol Oh

IPC分类号： A61K31/197 ,  A61P35/00 ,  A61P17/18 ,  A61P9/10 ,  A61K8/44 ,  A61P25/08 ,  A61P25/28 ,  A61Q19/02 ,  A61Q19/00 ,  C07C229/42 ,  A61P3/10

CPC分类号： C07C243/34 ,  A23L33/00 ,  A23V2002/00 ,  A61K8/42 ,  A61K2800/522 ,  A61Q19/02 ,  A61Q19/08 ,  A23V2200/02 ,  A23V2200/302

摘要： The present invention relates to a novel compound having excellent antioxidant activity, isolated from Ramalina terebrata, and more particularly to a novel compound, Ramalin, having excellent antioxidant activity, isolated from the Antarctic lichen Ramalina terebrata, a method for preparing the Ramalin, and a pharmaceutical composition, a functional food and a functional cosmetic composition, which contain the Ramalin as an active ingredient. The Ramalin according to the invention has significantly excellent antioxidant effects compared to commercially available antioxidants, and thus can be widely used in agents for treating oxidation-related diseases, anti-aging functional foods, functional cosmetic products for skin whitening and wrinkle reduction, etc.

摘要翻译： 本发明涉及一种从Ramalina terebrata分离得到的具有优异抗氧化活性的新型化合物，更具体地说涉及一种从南极地衣Ramalina terebrata中分离得到的具有优异抗氧化活性的新化合物Ramalin，制备Ramalin的方法和 药物组合物，功能性食品和功能性化妆品组合物，其含有拉马林作为活性成分。 根据本发明的拉马林与市售的抗氧化剂相比具有显着优异的抗氧化作用，因此可广泛用于治疗氧化相关疾病，抗衰老功能性食品，用于皮肤美白和皱纹减少的功能性化妆品等。

公开(公告)号：US20130116324A1

公开(公告)日：2013-05-09

申请号：US13701113

申请日：2011-06-02

申请人： Joung Han Yim ,  Il Chan Kim ,  Sung Gu Lee ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Sung Jin Kim ,  Tai Kyoung Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park ,  Suhkneung Pyo

发明人： Joung Han Yim ,  Il Chan Kim ,  Sung Gu Lee ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Sung Jin Kim ,  Tai Kyoung Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park ,  Suhkneung Pyo

IPC分类号： A61K31/198 ,  A61K45/06

CPC分类号： A61K31/198 ,  A61K31/45 ,  A61K45/06

摘要： The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen Ramalina terebrata, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-κB, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.

摘要翻译： 本发明涉及从南极地衣Ramalina terebrata分离的Ramalin的新用途（抗炎活性），更具体地涉及含有Ramalin作为活性成分的药物组合物。 本发明的Ramalin是衍生自天然材料的化合物，没有毒性或副作用，并且在转录期抑制诱导型一氧化氮合酶（iNOS）的表达，以显着抑制作为关键的一氧化氮（NO）的产生 炎症反应的介质。 此外，它抑制炎症介质NF-κB的活化，抑制p38 MAPK，ERK1 / 2和JNK信号通路，并抑制LPS受体TLR4的表达，提示Ramalin具有优异的抗炎作用。 因此，含有Ramalin的组合物可以有效地用于从根本上治疗或预防炎性疾病或免疫疾病，并缓解或缓解疾病的症状。