公开(公告)号：US07063968B2

公开(公告)日：2006-06-20

申请号：US10312932

申请日：2001-06-29

Applicant: Sang Yup Lee ,  Ho Nam Chang ,  Pyung Cheon Lee ,  Woo-gi Lee

Inventor： Sang Yup Lee ,  Ho Nam Chang ,  Pyung Cheon Lee ,  Woo-gi Lee

IPC: C12P7/40 ,  C12P7/54 ,  C12P7/56 ,  C12N1/20

CPC classification number: C12P7/56 ,  C12P7/46 ,  C12P7/54

Abstract: A novel microorganism capable of producing organic acids, Mannheimia sp. 55E, and a process for producing organic acid through anaerobic and aerobic incubation using the novel microorganism are provided. The method of producing an organic acid using the microorganism involves incubating Mannheimia sp. 55E with Accession Number KCTC 0769BP in a medium under anaerobic or aerobic conditions and obtaining an organic acid from the medium. Mannheimia sp. 55E produces succinic acid, lactic acid, and formic acid under anaerobic conditions saturated with CO2, and succinic acid, lactic acid, acetic acid, and formic acid under aerobic or N2 anaerobic conditions. Mannheimia sp. 55E is a facultative anaerobe tolerant of oxygen. Thus, the use of Mannheimia sp. 55E in producing organic acids can eliminate a problem of process instability, which would occur by the presence of oxygen in a fermentation process of producing organic acids using an obligate anaerobic microorganism.

Abstract translation: 一种能够生产有机酸的新型微生物，Mannheimia sp。 55E，并且提供了使用新型微生物通过厌氧和需氧培养来生产有机酸的方法。 使用该微生物生产有机酸的方法涉及培养Mannheimia sp。 55E，保藏号为KCTC 0769BP，在厌氧或需氧条件下培养，并从培养基中获得有机酸。 曼海星属 55E在CO 2饱和的厌氧条件下生成琥珀酸，乳酸和甲酸，在需氧或N 2 N下，产生琥珀酸，乳酸，乙酸和甲酸 >厌氧条件。 曼海星属 55E是耐受氧的兼性厌氧菌。 因此，使用曼海星属 55E在生产有机酸中可以消除过程不稳定的问题，这可能是由于在使用专用厌氧微生物生产有机酸的发酵过程中存在氧而发生的。

公开(公告)号：US08846750B2

公开(公告)日：2014-09-30

申请号：US13878196

申请日：2011-07-01

Applicant: Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

Inventor： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

IPC: A61K31/357 ,  C07D321/10 ,  A61K36/09 ,  A23L1/30 ,  C07D307/88 ,  C07D307/89 ,  C07D313/12

CPC classification number: C07D321/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/09 ,  C07D307/88 ,  C07D307/89 ,  C07D313/12 ,  A23V2200/3262 ,  A23V2200/332 ,  A23V2250/202

Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

公开(公告)号：US20130261174A1

公开(公告)日：2013-10-03

申请号：US13878196

申请日：2011-07-01

Applicant: Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

Inventor： Joung Han Yim ,  Il Chan Kim ,  Doc Kyu Kim ,  Se Jong Han ,  Hyoung Seok Lee ,  Bhattarai Hari Datta ,  Jung Eun Kim ,  Tai Kyoung Kim ,  Hyun Cheol Oh ,  Dong-Gyu Jo ,  Cheolsoon Lee ,  Keun-Sik Kim ,  Pyung Cheon Lee ,  Mi Ra Park ,  Yu-Kyung Park ,  Sung Jin Kim ,  Pil-Sung Kang ,  Heeyong Park ,  Ha Ju Park

IPC: C07D321/10

CPC classification number: C07D321/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/09 ,  C07D307/88 ,  C07D307/89 ,  C07D313/12 ,  A23V2200/3262 ,  A23V2200/332 ,  A23V2250/202

Abstract: The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the Stereocaulon alpinum. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

Abstract translation: 本发明涉及用于预防或治疗糖尿病或肥胖症的药物和食品组合物，更具体地涉及用于预防或治疗糖尿病或肥胖症的药物组合物和功能性食品，其含有由分离的化合物合成的新化合物作为活性成分 从Stereocaulon alpinum的提取物。 本发明的新型化合物具有非常优异的PTP-1b（蛋白酪氨酸磷酸酶-1b）抑制活性，仅在蛋白酪氨酸磷酸酶中仅对PTP-1b起作用，并且是可有效预防或治疗糖尿病的实质性PTP-1b抑制剂 肥胖。

公开(公告)号：US20090176287A1

公开(公告)日：2009-07-09

申请号：US11817120

申请日：2006-02-24

Applicant: Claudia Schmidt-Dannert ,  Benjamin N. Mijts ,  Pyung Cheon Lee

Inventor： Claudia Schmidt-Dannert ,  Benjamin N. Mijts ,  Pyung Cheon Lee

IPC: C12P7/24 ,  C12N1/00 ,  C12N1/21 ,  C07C47/02 ,  C07H21/00

CPC classification number: C12P23/00 ,  C12N9/00 ,  C12N9/0004 ,  C12N9/0069 ,  C12N9/1085

Abstract: This document provides methods and materials related to the production of carotenoids. For example, microorganisms containing one or more exogenous nucleic acids and producing detectable amounts of carotenoids are provided.

Abstract translation: 本文件提供了与类胡萝卜素生产相关的方法和材料。 例如，提供含有一种或多种外源核酸并产生可检测量的类胡萝卜素的微生物。

公开(公告)号：US06596521B1

公开(公告)日：2003-07-22

申请号：US09529570

申请日：2000-04-13

Applicant: Ho Nam Chang ,  Yong Keun Chang ,  Sun Hoon Kwon ,  Woo Gi Lee ,  Pyung Cheon Lee ,  Ik Keun Yoo ,  Seong Jin Lim

Inventor： Ho Nam Chang ,  Yong Keun Chang ,  Sun Hoon Kwon ,  Woo Gi Lee ,  Pyung Cheon Lee ,  Ik Keun Yoo ,  Seong Jin Lim

IPC: C12P740

CPC classification number: C12P7/46 ,  C12M23/58 ,  C12M29/18 ,  C12M41/26 ,  C12P7/40 ,  C12P7/42 ,  C12P7/48

Abstract: The present invention provides a method for manufacturing organic acid by high-efficiency fermentation, which comprises the steps of continuous culture of organic acid bacteria and collection of organic acid produced from the culture employing a cell-recycle multiple-stage continuous fermentor with serially connected fermentors, each of which comprises a fermentor containing a ferment container, temperature controller, stirrer, and pH controller; pumps for efflux-circulation of media from the fermentor; and, cell separator for separation and circulation of media from the pumps. According to the present method, the high-concentration lactic acid of 90 g/L can be produced with the high productivity of 50 g/L/h, which can reduce the facility cost and production cost in the bulk manufacturing process. In addition, the present invention can be effectively applied to the production of other organic acids such as acetic acid, formic acid, citric acid, malic acid, maleic acid, fumaric acid, and succinic acid, which show the end-product inhibition.

Abstract translation: 本发明提供了一种通过高效发酵制造有机酸的方法，其包括以下步骤：连续培养有机酸细菌和收集由使用连续发酵罐的细胞循环多级连续发酵罐的培养物产生的有机酸 ，其中每个包含含有发酵容器，温度控制器，搅拌器和pH控制器的发酵罐; 用于来自发酵罐的介质的外排循环的泵; 以及用于从泵分离和循环介质的细胞分离器。 根据本方法，可以以50g / L / h的高生产率生产90g / L的高浓度乳酸，这可以降低批量制造过程中的设备成本和生产成本。 此外，本发明可以有效地应用于生产其它有机酸如乙酸，甲酸，柠檬酸，苹果酸，马来酸，富马酸和琥珀酸，这些有机酸显示出最终产物的抑制作用。