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1.5-substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents 失效
标题翻译: 5-取代的喹啉和异喹啉衍生物,其制备方法及其作为抗炎剂的用途公开(公告)号:US07417056B2
公开(公告)日:2008-08-26
申请号:US11272009
申请日:2005-11-14
申请人: Stefan Jaroch , Hartmut Rehwinkel , Heike Schaecke , Norbert Schmees , Werner Skuballa , Jan Huebner , Orlin Petrov , Matthias Schneider , Christian Dinter
发明人: Stefan Jaroch , Hartmut Rehwinkel , Heike Schaecke , Norbert Schmees , Werner Skuballa , Jan Huebner , Orlin Petrov , Matthias Schneider , Christian Dinter
IPC分类号: C07D405/02 , A61K31/47
CPC分类号: C07D405/12
摘要: Compounds of general formula (IIa) or (IIb) and their use as pharmaceutical agents.
摘要翻译: 通式(IIa)或(IIb)的化合物及其作为药剂的用途。
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2.Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents 审中-公开
标题翻译: 四氢萘衍生物,其生产方法及其作为抗炎剂的用途公开(公告)号:US20070015761A1
公开(公告)日:2007-01-18
申请号:US11399610
申请日:2006-04-07
IPC分类号: A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4706 , A61K31/4745 , A61K31/4184 , A61K31/416 , A61K31/405
CPC分类号: C07D239/42
摘要: The invention relates to polysubstituted tetrahydronaphthalene derivatives of formula (I), process for their production and their use as anti-inflammatory agents.
摘要翻译: 本发明涉及式(I)的多取代四氢萘衍生物,其制备方法及其作为抗炎剂的用途。
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3.
公开(公告)号:US20070015750A1
公开(公告)日:2007-01-18
申请号:US11399590
申请日:2006-04-07
申请人: Stefan Baeurle , Heike Schaecke , Markus Berger , Anne Mengel
发明人: Stefan Baeurle , Heike Schaecke , Markus Berger , Anne Mengel
IPC分类号: A61K31/538 , A61K31/517 , A61K31/502
CPC分类号: C07C49/755 , C07C41/30 , C07C43/23 , C07C45/29 , C07C45/65 , C07C2602/10
摘要: The invention relates to polysubstituted tetrahydronaphthalene derivatives of formula (I), process for their production and their use as anti-inflammatory agents.
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4.Process for characterization of the transactivation and transrepression activity of glucocorticoid receptor ligands in primary immune cells 审中-公开
标题翻译: 表征初级免疫细胞中糖皮质激素受体配体的反式激活和反式抑制活性的方法公开(公告)号:US20060275800A1
公开(公告)日:2006-12-07
申请号:US11414550
申请日:2006-05-01
申请人: Wolf Doecke , Christine Rentzsch , Heike Schaecke , Norbert Schmees , Hartmut Rehwinkel , Bettina Schulz , Patrick Golletz , Christine Stock
发明人: Wolf Doecke , Christine Rentzsch , Heike Schaecke , Norbert Schmees , Hartmut Rehwinkel , Bettina Schulz , Patrick Golletz , Christine Stock
CPC分类号: G01N33/5023 , G01N33/5047 , G01N33/743 , G01N2333/723
摘要: The invention relates to a process for the characterization of the transactivation and transrepression activity of glucocorticoid receptor (GR) ligands by gene and/or protein expression analysis in primary immune cells as well as the use thereof.
摘要翻译: 本发明涉及通过基因和/或蛋白质表达分析在初级免疫细胞中表征糖皮质激素受体(GR)配体的反式激活和反式抑制活性的方法及其用途。
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5.Substituted pentanols, a process for their production and their use as anti-inflammatory agents 失效
标题翻译: 取代的戊醇,其生产方法及其作为抗炎剂的用途公开(公告)号:US20050143415A1
公开(公告)日:2005-06-30
申请号:US10957742
申请日:2004-10-05
申请人: Stefan Jaroch , Stefan Baeurle , Markus Berger , Konrad Krolikiewicz , Duy Nguyen , Hartmut Rehwinkel , Norbert Schmees , Werner Skuballa , Heike Schaecke
发明人: Stefan Jaroch , Stefan Baeurle , Markus Berger , Konrad Krolikiewicz , Duy Nguyen , Hartmut Rehwinkel , Norbert Schmees , Werner Skuballa , Heike Schaecke
IPC分类号: A61K31/47 , C07D215/38 , C07D217/22
CPC分类号: C07D215/38 , C07D217/22
摘要: The invention relates to substituted pentanols, a process for their production and their use as anti-inflammatory agents.
摘要翻译: 本发明涉及取代戊醇,其制备方法及其作为抗炎剂的用途。
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6.Benzyl amines, a process for their production and their use as anti-inflammatory agents 有权
标题翻译: 苄胺,其生产方法及其用作抗炎剂公开(公告)号:US08461346B2
公开(公告)日:2013-06-11
申请号:US13465746
申请日:2012-05-07
申请人: Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schaecke
发明人: Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schaecke
IPC分类号: C07D215/38
CPC分类号: C07C215/16 , C07B2200/07 , C07C215/28 , C07C217/70 , C07C317/28 , C07D215/38 , C07D233/84 , C07D401/12 , C07D405/12 , C07D405/14
摘要: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译: 本发明涉及式I化合物,其制备方法及其作为抗炎剂的用途。
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7.CYCLIC PHENYL-SUBSTITUTED INDAZOLS, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译: 环状苯基取代的吲哚,其生产过程及其作为抗炎剂的用途公开(公告)号:US20080227820A1
公开(公告)日:2008-09-18
申请号:US11931090
申请日:2007-10-31
申请人: Markus Berger , Hartmut Rehwinkel , Heike Schaecke , Matti Lepisto , Karl Edmann
发明人: Markus Berger , Hartmut Rehwinkel , Heike Schaecke , Matti Lepisto , Karl Edmann
IPC分类号: A61K31/4439 , A61P29/00 , C07D231/56 , C07D401/04 , A61K31/404 , C07D209/08 , C07D405/02 , A61K31/416
CPC分类号: C07D231/56 , C07D209/08 , C07D401/04 , C07D405/04 , C07D405/12 , C07D405/14
摘要: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译: 本发明涉及式I化合物,其制备方法及其作为抗炎剂的用途。
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公开(公告)号:US07166592B2
公开(公告)日:2007-01-23
申请号:US10874485
申请日:2004-06-24
申请人: Stefan Jaroch , Manfred Lehmann , Norbert Schmees , Bernd Buchmann , Harmur Rehwinkel , Peter Droescher , Werner Skuballa , Konrad Krolikiewicz , Hartwig Hennekes , Heike Schaecke , Arndr Schottelius
发明人: Stefan Jaroch , Manfred Lehmann , Norbert Schmees , Bernd Buchmann , Harmur Rehwinkel , Peter Droescher , Werner Skuballa , Konrad Krolikiewicz , Hartwig Hennekes , Heike Schaecke , Arndr Schottelius
IPC分类号: C07D265/02 , A61K31/536
CPC分类号: C07D413/12 , A61K31/365 , A61K31/536 , C07D265/02 , C07D307/88
摘要: Compounds of Formula 1 are useful in the treatment of inflammation.
摘要翻译: 式1的化合物可用于治疗炎症。
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9.Benzocycloheptene derivatives, process for their production and their use as anti-inflammatory agents 审中-公开
标题翻译: 苯并环庚烯衍生物,其制备方法及其作为抗炎剂的用途公开(公告)号:US20060247292A1
公开(公告)日:2006-11-02
申请号:US11384809
申请日:2006-03-21
申请人: Hartmut Rehwinkel , Duy Nguyen , Markus Berger , Heike Schaecke
发明人: Hartmut Rehwinkel , Duy Nguyen , Markus Berger , Heike Schaecke
IPC分类号: A61K31/415
CPC分类号: C07D209/34 , C07D215/22 , C07D231/56 , C07D403/04
摘要: The invention relates to polysubstituted 5H-benzocycloheptene derivatives of formula (I) process for their production, and their use as anti-inflammatory agents.
摘要翻译: 本发明涉及式(I)的多取代的5H-苯并环庚烯衍生物的制备方法及其作为抗炎剂的用途。
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公开(公告)号:US07109212B2
公开(公告)日:2006-09-19
申请号:US11059682
申请日:2005-02-17
申请人: Stefan Jaroch , Manfred Lehmann , Norbert Schmees , Markus Berger , Hartmut Rehwinkel , Konrad Krolikiewicz , Werner Skuballa , Heike Schaecke , Arndt. J. G. Schottelius
发明人: Stefan Jaroch , Manfred Lehmann , Norbert Schmees , Markus Berger , Hartmut Rehwinkel , Konrad Krolikiewicz , Werner Skuballa , Heike Schaecke , Arndt. J. G. Schottelius
IPC分类号: A61K31/47 , A61K31/472 , C07D217/24 , C07D217/00 , C07D215/38
CPC分类号: C07D405/12 , A61K31/47 , C07D215/40 , C07D217/24
摘要: The invention relates to quinoline and isoquinoline derivatives of general formula I and a process for their production, and their use as inflammation inhibitors.
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