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公开(公告)号：US09603354B2
公开(公告)日：2017-03-28
申请号：US13152056
申请日：2011-06-02
申请人： Herbert de Groot , Ursula Rauen , Gernot Koehler , Wilfried Bruns
发明人： Herbert de Groot , Ursula Rauen , Gernot Koehler , Wilfried Bruns
CPC分类号： A01N1/02 , A01N1/0205 , A01N1/0226
摘要： Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ions, and if need be also alkaline earth ions as the electrolyte, a buffer e.g. on a histidine derivation basis, as well as a polyol and/or a saccharide, has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and to which hydroxamic acid, and/or one or more hydroxamic acid derivatives are added.
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公开(公告)号：US07977383B2
公开(公告)日：2011-07-12
申请号：US10438977
申请日：2003-05-16
申请人： Herbert de Groot , Ursula Rauen , Gernot Koehler , Wilfried Bruns
发明人： Herbert de Groot , Ursula Rauen , Gernot Koehler , Wilfried Bruns
CPC分类号： A01N1/02 , A01N1/0205 , A01N1/0226
摘要： Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ions, and if need be also alkaline earth ions as the electrolyte, a buffer e.g. on a histidine derivation basis, as well as a polyol and/or a saccharide, has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and to which hydroxamic acid, and/or one or more hydroxamic acid derivatives are added.
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公开(公告)号：US08945611B2
公开(公告)日：2015-02-03
申请号：US13003400
申请日：2009-07-08
CPC分类号： A61K9/0026 , A01N1/02 , A01N1/0226 , A61K9/1647 , A61K9/5031 , A61K9/5153 , A61K31/755
摘要： The invention relates to dispersions of artificial oxygen carriers, wherein the dispersions contain capsules with reversible oxygen storage capacity, the capsules comprising an oxygen-permeable capsule material, that contains and/or encloses fluorinated, particularly perfluorinated hydrocarbons, preferably perfluorocarbons. The dispersions are particularly suitable as a blood substitute, preferably for the purpose of transfusion, e.g. in states of blood loss of the human or animal body, in particular following surgical interventions, accidents, injuries etc, or for the prophylactic treatment and/or treatment by therapy of ischaemic states or states following a reperfusion.
摘要翻译： 本发明涉及人造氧载体的分散体，其中分散体含有具有可逆储氧能力的胶囊，所述胶囊包含透氧胶囊材料，其含有和/或包围氟化的，特别是全氟化烃，优选全氟化碳。 分散体特别适合作为血液替代物，优选用于输血的目的，例如， 在人或动物身体的失血状态下，特别是在手术干预，事故，损伤等之后，或通过再灌注后缺血状态或状态的治疗进行预防性治疗和/或治疗。
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公开(公告)号：US20110300237A1
公开(公告)日：2011-12-08
申请号：US13152056
申请日：2011-06-02
申请人： Herbert de Groot , Ursula Rauen , Gernot Koehler , Wilfried Bruns
发明人： Herbert de Groot , Ursula Rauen , Gernot Koehler , Wilfried Bruns
CPC分类号： A01N1/02 , A01N1/0205 , A01N1/0226
摘要： Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ions, and if need be also alkaline earth ions as the electrolyte, a buffer e.g. on a histidine derivation basis, as well as a polyol and/or a saccharide, has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and to which hydroxamic acid, and/or one or more hydroxamic acid derivatives are added.
摘要翻译： 描述了一种保护性解决方案，用于避免缺血，储存或缺血/再灌注到器官或分离的细胞系统，或灌注，手术，移植或冷冻保存后的组织成分以及随后的含有碱离子的再灌注，如果需要也 碱土离子作为电解质，缓冲剂例如 以组氨酸衍生为基础，以及多元醇和/或糖类，具有约290mos / l至约350mos / l的渗透压，以及约6.8至约7.4的pH值，并且其中异羟肟酸 酸，和/或一种或多种异羟肟酸衍生物。
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公开(公告)号：US20110223243A1
公开(公告)日：2011-09-15
申请号：US13003400
申请日：2009-07-08
CPC分类号： A61K9/0026 , A01N1/02 , A01N1/0226 , A61K9/1647 , A61K9/5031 , A61K9/5153 , A61K31/755
摘要： The invention relates to dispersions of artificial oxygen carriers, wherein the dispersions contain capsules with reversible oxygen storage capacity, the capsules comprising an oxygen-permeable capsule material, that contains and/or encloses fluorinated, particularly perfluorinated hydrocarbons, preferably perfluorocarbons. The dispersions are particularly suitable as a blood substitute, preferably for the purpose of transfusion, e.g. in states of blood loss of the human or animal body, in particular following surgical interventions, accidents, injuries etc, or for the prophylactic treatment and/or treatment by therapy of ischaemic states or states following a reperfusion.
摘要翻译： 本发明涉及人造氧载体的分散体，其中分散体含有具有可逆储氧能力的胶囊，所述胶囊包含透氧胶囊材料，其含有和/或包围氟化的，特别是全氟化烃，优选全氟化碳。 分散体特别适合作为血液替代物，优选用于输血的目的，例如， 在人或动物身体的失血状态下，特别是在手术干预，事故，损伤等之后，或通过再灌注后缺血状态或状态的治疗进行预防性治疗和/或治疗。
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