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公开(公告)号:US20100203083A1
公开(公告)日:2010-08-12
申请号:US12601651
申请日:2008-06-02
申请人: Kerstin Lux , Hildegard Buening , Luca Perabo , John Nieland , Jorge Boucas , Michael Hallek , Mirko Ritter , Markus Hoerer
发明人: Kerstin Lux , Hildegard Buening , Luca Perabo , John Nieland , Jorge Boucas , Michael Hallek , Mirko Ritter , Markus Hoerer
IPC分类号: A61K39/23 , C07K14/015 , C07H21/04 , C12N15/63 , C12N7/04 , A61K38/16 , A61K31/7088 , A61P37/00 , A61P35/04 , A61P25/28 , A61P31/00
CPC分类号: C07K14/015 , A61K2039/5256 , A61K2039/5258 , C07K14/005 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14145 , C12N2810/405
摘要: The present invention is related to a structural protein of a parvovirus with an amino acid insertion at the insertion site I-453, a library comprising the protein, a multimeric structure comprising the protein, a nucleic acid encoding the protein, a vector, virus or cell comprising the nucleic acid, a process for the preparation of the protein, a medicament comprising the protein, nucleic acid or multimeric structure as well as methods and uses involving the protein, nucleic acid or multimeric structure.
摘要翻译: 本发明涉及在插入位点I-453处具有氨基酸插入的细小病毒的结构蛋白质,包含该蛋白质的文库,包含该蛋白质的多聚体结构,编码该蛋白质的核酸,载体,病毒或 包含核酸的细胞,制备蛋白质的方法,包含蛋白质,核酸或多聚体结构的药物以及涉及蛋白质,核酸或多聚体结构的方法和用途。
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公开(公告)号:US20100297177A1
公开(公告)日:2010-11-25
申请号:US12601639
申请日:2008-06-02
申请人: Hildegard Buening , John Nieland , Luca Perabo , Daniela Kuehn , Kerstin Lux , Michael Hallek , Markus Hoerer , Mirko Ritter
发明人: Hildegard Buening , John Nieland , Luca Perabo , Daniela Kuehn , Kerstin Lux , Michael Hallek , Markus Hoerer , Mirko Ritter
IPC分类号: A61K39/23 , C40B30/04 , C07K14/00 , C07H21/04 , C12N7/01 , C12P21/00 , A61K38/00 , A61P37/04
CPC分类号: G01N33/56983 , A61K39/00 , A61K2039/5256 , C07K14/005 , C07K16/081 , C07K16/4291 , C07K2317/34 , C07K2317/76 , C12N2750/14122 , C12N2750/14143 , G01N2333/015 , G01N2500/04
摘要: The present invention is related to a method for identifying a parvovirus mutated structural protein capable of specifically binding to a binder for an antigen, a parvovirus mutated structural protein which comprises at least one B-cell epitope heterologous to the parvovirus, a multimeric structure comprising the protein, a nucleic acid encoding the protein, a virus or cell comprising the protein, a method of preparing the protein, a medicament comprising the protein, nucleic acid or multimeric structure and its use.
摘要翻译: 本发明涉及用于鉴定能够特异性结合抗原的粘合剂的细小病毒突变结构蛋白的方法,包括至少一个与细小病毒异源的B细胞表位的细小病毒突变的结构蛋白,包含 蛋白质,编码蛋白质的核酸,包含蛋白质的病毒或细胞,制备蛋白质的方法,包含蛋白质,核酸或多聚体结构的药物及其用途。
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