公开(公告)号：US20060057254A1

公开(公告)日：2006-03-16

申请号：US10538693

申请日：2003-10-03

申请人： Yoshitane Kojima ,  Yutaka Yoshikawa ,  Naemi Kajiwara ,  Hiroko Anzai ,  Hiroshi Taniguchi

发明人： Yoshitane Kojima ,  Yutaka Yoshikawa ,  Naemi Kajiwara ,  Hiroko Anzai ,  Hiroshi Taniguchi

IPC分类号： A23L1/30

CPC分类号： A61K45/06 ,  A23L33/105 ,  A23L33/16 ,  A23V2002/00 ,  A61K33/00 ,  A61K33/30 ,  A61K36/064 ,  A61K36/16 ,  A61K36/185 ,  A61K36/31 ,  A61K2300/00 ,  A23V2250/1642

摘要： Zinc (II) ions (zinc sulfate, zinc acetate and the like) originated in inorganic salts making it difficult for such ions to pass through biological membranes, thus being difficult to be incorporated in a human body. For overcoming such problems, it is necessary to develop food products with a prophylactic effect against diabetes, which contain zinc sources and have a lower toxicity than zinc (II) ions, a good stability and good fat-solubility. The present invention provides food products which have a prophylactic effect against diabetes using specified health foods, nutritional (functional) foods or the like containing natural substances that contain zinc in high concentrations (plants such as papaya, maca and the like, and yeasts such as baker's yeast, brewer's yeast and the like).

摘要翻译： 锌（II）离子（硫酸锌，乙酸锌等）起源于无机盐，使得这些离子难以通过生物膜，因此难以掺入人体内。 为了克服这些问题，有必要开发具有预防糖尿病的食品，其含有锌源，毒性低于锌（II）离子，具有良好的稳定性和良好的脂溶性。 本发明提供了使用特定保健食品，营养（功能性）食品等含有高浓度锌的天然物质（植物如番木瓜，马卡类等）和酵母菌等的具有预防糖尿病作用的食品 面包师酵母，啤酒酵母等）。

公开(公告)号：US20080112956A1

公开(公告)日：2008-05-15

申请号：US10580567

申请日：2004-11-25

申请人： Koji Nakamura ,  Hiroko Anzai ,  Hiroyuki Yanai ,  Atsushi Miyajima

发明人： Koji Nakamura ,  Hiroko Anzai ,  Hiroyuki Yanai ,  Atsushi Miyajima

IPC分类号： A61K39/395 ,  C12Q1/68 ,  A61P1/16 ,  G01N33/574

CPC分类号： C07K16/28 ,  C07K16/303 ,  C07K2317/734 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57438 ,  G01N2333/9121

摘要： Disclosed are a method for detecting liver cancer capable of detecting liver cancer with high specificity and a diagnostic therefor, as well as a novel therapeutic drug for cancer having an excellent anticancer effect. The method for detecting liver cancer cells in a sample utilizes as an index the expression of dlk gene. The expression of dlk gene may be measured by immunoassay using an anti-dlk antibody or by measuring mRNA of dlk gene. The therapeutic drug for cancer comprises as an effective ingredient an antibody which undergoes antigen-antibody reaction with Dlk expressing on surfaces of cancer cells and which exerts anticancer action against the cancer cells.

摘要翻译： 公开了一种能够高特异性检测肝癌的肝癌检测方法及其诊断方法，以及具有优异抗癌作用的新型癌症治疗药物。 检测样品中肝癌细胞的方法用作dlk基因的表达指标。 dlk基因的表达可以通过使用抗dlk抗体的免疫测定或通过测定dlk基因的mRNA来测量。 用于癌症的治疗药物包含作为有效成分的抗体，其与在癌细胞表面上表达的D1K进行抗原抗体反应并对癌细胞发挥抗癌作用。

公开(公告)号：US20100151503A1

公开(公告)日：2010-06-17

申请号：US12480465

申请日：2009-06-08

申请人： KOJI NAKAMURA ,  HIROKO ANZAI ,  HIROYUKI YANAI ,  ATSUSHI MIYAJIMA

发明人： KOJI NAKAMURA ,  HIROKO ANZAI ,  HIROYUKI YANAI ,  ATSUSHI MIYAJIMA

IPC分类号： G01N33/574

CPC分类号： C07K16/28 ,  C07K16/303 ,  C07K2317/734 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57438 ,  G01N2333/9121

摘要： Disclosed are a method for detecting liver cancer capable of detecting liver cancer with high specificity and a diagnostic therefor, as well as a novel therapeutic drug for cancer having an excellent anticancer effect. The method for detecting liver cancer cells in a sample utilizes as an index the expression of dlk gene. The expression of dlk gene may be measured by immunoassay using an anti-dlk antibody or by measuring mRNA of dlk gene. The therapeutic drug for cancer comprises as an effective ingredient an antibody which undergoes antigen-antibody reaction with Dlk expressing on surfaces of cancer cells and which exerts anticancer action against the cancer cells.

摘要翻译： 公开了一种能够高特异性检测肝癌的肝癌检测方法及其诊断方法，以及具有优异抗癌作用的新型癌症治疗药物。 检测样品中肝癌细胞的方法用作dlk基因的表达指标。 dlk基因的表达可以通过使用抗dlk抗体的免疫测定或通过测定dlk基因的mRNA来测量。 用于癌症的治疗药物包含作为有效成分的抗体，其与在癌细胞表面上表达的D1K进行抗原抗体反应并对癌细胞发挥抗癌作用。