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公开(公告)号：US08034574B2
公开(公告)日：2011-10-11
申请号：US12302808
申请日：2007-10-05
申请人： Katsura Nozawa , Eri Shoda , Hitoshi Doihara , Ryosuke Kojima
发明人： Katsura Nozawa , Eri Shoda , Hitoshi Doihara , Ryosuke Kojima
IPC分类号： G01N33/53 , G01N33/566 , C12Q1/68
CPC分类号： G01N33/6872 , G01N33/942 , G01N2500/10
摘要： The present invention provides a screening tool and screening method for obtaining a substance useful as a prophylactic and/or therapeutic drug for diseases associated with 5-HT production/secretion abnormalities, including digestive organ diseases, and a prophylactic and/or therapeutic drug for diseases associated with 5-HT production/secretion abnormalities, including digestive organ diseases. Examples of digestive organ diseases in the present invention include constipation type irritable bowel syndrome, functional dyspepsia, constipation, diarrhea type irritable bowel syndrome, diarrhea and vomiting.
摘要翻译： 本发明提供了一种筛选工具和筛选方法，用于获得用作与5-HT生产/分泌异常（包括消化器官疾病）相关疾病的预防和/或治疗药物的物质，以及用于疾病的预防和/或治疗药物 与5-HT生产/分泌异常有关，包括消化器官疾病。 本发明的消化器官疾病的实例包括便秘型肠易激综合征，功能性消化不良，便秘，腹泻型肠易激综合征，腹泻和呕吐。
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公开(公告)号：US20110009379A1
公开(公告)日：2011-01-13
申请号：US12922936
申请日：2009-03-30
IPC分类号： A61K31/404 , C07D209/38 , A61P1/10 , C07D403/06 , A61K31/4155 , C07D401/06 , A61K31/4439 , C07D417/06 , A61K31/427 , C07D405/06 , C07D413/06 , A61K31/5377 , A61K31/496
CPC分类号： C07D209/34 , C07D209/38 , C07D401/06 , C07D403/06 , C07D405/06 , C07D417/06
摘要： [Problems] A compound, which is useful as an active ingredient for a pharmaceutical composition, for example a pharmaceutical composition for treating constipation-type irritable bowel syndrome, atonic constipation and/or functional gastrointestinal disorder, is provided.[Means for Solution] The present inventors have extensively studied compounds having TRPA1 channel activation activity, and confirmed that an indolinone compound has a TRPA1 channel activation activity, and thus completed the present invention. The indolinone compound of the present invention has a TRPA1 channel activation activity and can be used as an active ingredient of a pharmaceutical composition for preventing and/or treating constipation-type irritable bowel syndrome, atonic constipation and/or functional gastrointestinal disorder or the like.
摘要翻译： [问题]提供了可用作药物组合物的活性成分的化合物，例如用于治疗便秘型肠易激综合征，非便秘便秘和/或功能性胃肠病症的药物组合物。 [解决方案]本发明人广泛研究了具有TRPA1通道活化活性的化合物，并证实了吲哚啉酮化合物具有TRPA1通道活化活性，从而完成了本发明。 本发明的吲哚满酮化合物具有TRPA1通道活化活性，可用作预防和/或治疗便秘型肠易激综合征，无症状便秘和/或功能性胃肠功能紊乱等的药物组合物的活性成分。
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公开(公告)号：US20100129345A1
公开(公告)日：2010-05-27
申请号：US12302808
申请日：2007-10-05
申请人： Katsura Nozawa , Eri Shoda , Hitoshi Doihara , Ryosuke Kojima
发明人： Katsura Nozawa , Eri Shoda , Hitoshi Doihara , Ryosuke Kojima
IPC分类号： A61K39/395 , G01N33/53 , A61K31/7088 , A61K38/16 , A61P1/00
CPC分类号： G01N33/6872 , G01N33/942 , G01N2500/10
摘要： The present invention provides a screening tool and screening method for obtaining a substance useful as a prophylactic and/or therapeutic drug for diseases associated 5 with 5-HT production/secretion abnormalities, including digestive organ diseases, and a prophylactic and/or therapeutic drug for diseases associated with 5-HT production/secretion abnormalities, including digestive organ diseases. Examples of digestive organ diseases in the present invention include constipation type irritable bowel syndrome, functional dyspepsia, constipation, diarrhea type irritable bowel syndrome, diarrhea and vomiting.
摘要翻译： 本发明提供一种筛选工具和筛选方法，用于获得可用作与5-HT产生/分泌异常（包括消化器官疾病）相关的疾病的预防和/或治疗药物的预防和/或治疗药物，以及用于 与5-HT生产/分泌异常有关的疾病，包括消化器官疾病。 本发明的消化器官疾病的实例包括便秘型肠易激综合征，功能性消化不良，便秘，腹泻型肠易激综合征，腹泻和呕吐。
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公开(公告)号：US20080188512A1
公开(公告)日：2008-08-07
申请号：US12027564
申请日：2008-02-07
申请人： Ryuichi Takezawa , Hitoshi Doihara , Hiroyuki Ito , Jotaro Suzuki
发明人： Ryuichi Takezawa , Hitoshi Doihara , Hiroyuki Ito , Jotaro Suzuki
IPC分类号： A61K31/437 , A61K31/444 , A61P1/12 , A61P1/00
CPC分类号： A61K31/437 , A61K31/444
摘要： N-(1H-tetrazol-5-yl)-1-phenoxy-4H-quinolizin-4-one-3-carboxamide is effective for treating IBS. In addition, IBS may be effectively treated with N-(1H-tetrazol-5-yl)-1-phenoxy-4H-quinolizin-4-one-3-carboxamide when used concomitantly with at least one of various serotonin 5-HT3 receptor antagonists.
摘要翻译： N-（1H-四唑-5-基）-1-苯氧基-4H-喹嗪酮-4-酮-3-甲酰胺对于治疗IBS是有效的。 另外，当与各种5-羟色胺5-HT 3受体中的至少一种同时使用时，可以用N-（1H-四唑-5-基）-1-苯氧基-4H-喹诺酮-4-酮-3-甲酰胺有效地处理IBS 拮抗剂
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公开(公告)号：US07842702B2
公开(公告)日：2010-11-30
申请号：US12027564
申请日：2008-02-07
申请人： Ryuichi Takezawa , Hitoshi Doihara , Hiroyuki Ito , Jotaro Suzuki
发明人： Ryuichi Takezawa , Hitoshi Doihara , Hiroyuki Ito , Jotaro Suzuki
IPC分类号： A61K31/4375
CPC分类号： A61K31/437 , A61K31/444
摘要： N-(1H-tetrazol-5-yl)-1-phenoxy-4H-quinolizin-4-one-3-carboxamide is effective for treating IBS. In addition, IBS may be effectively treated with N-(1H-tetrazol-5-yl)-1-phenoxy-4H-quinolizin-4-one-3-carboxamide when used concomitantly with at least one of various serotonin 5-HT3 receptor antagonists.
摘要翻译： N-（1H-四唑-5-基）-1-苯氧基-4H-喹嗪酮-4-酮-3-甲酰胺对于治疗IBS是有效的。 另外，当与各种5-羟色胺5-HT 3受体中的至少一种同时使用时，可以用N-（1H-四唑-5-基）-1-苯氧基-4H-喹诺酮-4-酮-3-甲酰胺有效地处理IBS 拮抗剂
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