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    Encapsulated toner processes
    3.
    发明授权
    Encapsulated toner processes 失效
    封装墨粉处理

    公开(公告)号：US5283153A

    公开(公告)日：1994-02-01

    申请号：US868745

    申请日：1992-04-15

    申请人： Guerino G. Sacripante ,  Grazyna E. Kmiecik-Lawrynowicz ,  Hock S. Tan ,  Raj D. Patel

    发明人： Guerino G. Sacripante ,  Grazyna E. Kmiecik-Lawrynowicz ,  Hock S. Tan ,  Raj D. Patel

    IPC分类号： B01J13/14 ,  G03G9/08 ,  G03G9/093

    CPC分类号： G03G9/093 ,  G03G9/09371 ,  G03G9/09392

    摘要： A process for the preparation of encapsulated toner compositions which comprises dispersing a mixture of addition monomers, an optional preformed polymer resin, a free radical initiator, a colorant comprised of a pigment, dye or mixtures thereof, and shell forming monomer in an aqueous medium containing a cellulose polymer and a first ionic surfactant thereby forming a stable microdroplet suspension; and subsequently adding an aqueous solution of a second stabilizing surfactant followed by the formation of a soluble monomer forming shell wall by interfacial polymerization, and thereafter initiating and completing the core resin-forming free radical polymerization by heating thereby resulting in toner compositions with an average volume particle size of from about 3 to about 7 microns.

    摘要翻译： 一种制备包封的调色剂组合物的方法，其包括将添加单体的混合物，任选的预成型聚合物树脂，自由基引发剂，由颜料，染料或其混合物组成的着色剂和形成壳的单体混合在含有 纤维素聚合物和第一离子表面活性剂，从而形成稳定的微滴悬浮液; 然后加入第二稳定化表面活性剂的水溶液，然后通过界面聚合形成形成壳壁的可溶性单体，然后通过加热引发和完成形成核心树脂的自由基聚合，从而得到平均体积的调色剂组合物 粒径为约3至约7微米。

    Processes for encapsulated toners
    4.
    发明授权
    Processes for encapsulated toners 失效
    封装调色剂的方法

    公开(公告)号：US5114824A

    公开(公告)日：1992-05-19

    申请号：US592092

    申请日：1990-10-01

    申请人： Hock S. Tan ,  Tie H. Ng ,  Hadi K. Mahabadi

    发明人： Hock S. Tan ,  Tie H. Ng ,  Hadi K. Mahabadi

    IPC分类号： G03G9/08 ,  G03G9/087 ,  G03G9/093

    CPC分类号： G03G9/09392 ,  Y10T428/2989

    摘要： A process for the preparation of encapsulated toner which comprises (1) mixing a blend of a core monomer or monomers, free radical chemical initiator, pigment, and an oil soluble shell monomer to form an organic phase; (2) dispersing the resulting organic phase in the absence of surfactant or stabilizer in an aqueous solution comprised of a water-soluble shell monomer whereby interfacial shell polymerization is initiated; (3) stirring the resulting suspension to allow completion of interfacial shell polymerization; (4) initiating free radical core polymerization by increasing the temperature of the suspension from ambient to about 75.degree. to about 90.degree. C.; (5) completing core polymerization by maintaining the aforementioned temperature in step (4) for an effective period of time; (6) cooling; (7) filtering; and (8) drying.

    摘要翻译： 一种制备包封调色剂的方法，其包括（1）将核心单体或单体，自由基化学引发剂，颜料和油溶性壳单体的共混物混合以形成有机相; （2）在不含表面活性剂或稳定剂的情况下将所得有机相分散在由水溶性壳单体组成的水溶液中，从而开始界面壳聚合; （3）搅拌所得悬浮液以完成界面壳聚合; （4）通过将悬浮液的温度从环境温度升高至约75℃至约90℃来引发自由基核聚合; （5）通过将步骤（4）中的上述温度维持有效的时间来完成核聚合; （6）冷却; （7）过滤; 和（8）干燥。

    TRANSDERMAL DRUG DELIVERY SYSTEM FOR KETAMINE
    5.
    发明申请
    TRANSDERMAL DRUG DELIVERY SYSTEM FOR KETAMINE 审中-公开

    公开(公告)号：US20200030251A1

    公开(公告)日：2020-01-30

    申请号：US16603729

    申请日：2018-04-19

    申请人： Huadong TANG ,  Hock S. TAN ,  Michael MAYERSOHN ,  GUANGZHOU DAZHOU BIOMEDICINE LTD.

    发明人： Huadong TANG ,  Hock S. TAN ,  Michael MAYERSOHN

    IPC分类号： A61K9/70 ,  A61K31/135

    摘要： Provided herein are ketamine gel formulations, transdermal delivery devices comprising ketamine, methods of preparation and methods of using thereof. The transdermal delivery device can be a drug-in-reservoir (DIR) patch comprising ketamine, which typically includes a backing layer, a reservoir layer comprising a ketamine gel formulation, a rate-controlling membrane, an adhesive layer, and a release liner. The ketamine gel formulation generally includes one or more skin permeation enhancers. The transdermal delivery devices can be configured, for example, by adjusting the ketamine gel formulation and other release control mechanisms, to provide certain skin flux characteristics, and can be used for treating a variety of indications such as depression and/or pain.

    Enhancer tolerant pressure sensitive adhesives for transdermal drug delivery
    6.
    发明授权
    Enhancer tolerant pressure sensitive adhesives for transdermal drug delivery 失效
    用于透皮药物递送的增强剂耐受性压敏粘合剂

    公开(公告)号：US6077527A

    公开(公告)日：2000-06-20

    申请号：US958862

    申请日：1997-10-28

    申请人： Hock S. Tan ,  Ingrid Zhang ,  Susan Lydzinski ,  Peter L. Merkel ,  Paul Foreman ,  Smita Shah ,  Rama S. Chandran

    发明人： Hock S. Tan ,  Ingrid Zhang ,  Susan Lydzinski ,  Peter L. Merkel ,  Paul Foreman ,  Smita Shah ,  Rama S. Chandran

    IPC分类号： A61K9/70 ,  C09J4/00 ,  C09J133/08 ,  C09J133/26 ,  A61F13/02

    CPC分类号： A61K9/7061 ,  C09J133/26 ,  C09J4/00 ,  Y10T428/28 ,  Y10T428/2887

    摘要： Pressure sensitive adhesive compositions for use in transdermal drug delivery systems comprising an adhesive composition which is tolerant to plasticization by cutaneous penetration enhancers contained in the transdermal drug formulation are disclosed. Specifically, the pressure sensitive adhesive composition of the present invention comprises an acrylic copolymer prepared from (i) at least 40% by weight of th total monomer composition of alkyl acrylate monomers with a Tg of -90 to 0.degree. C., (ii) 0-15% by weight of the total monomer composition of monomers with a Tg of 0 to 250.degree. C., and (iii) 10-60% by weight of the total monomer composition of substituted acrylamides or methacrylamides having the structural formula: ##STR1## wherein R.sub.1 is H or CH.sub.3,R.sub.2 is H or CH.sub.3, andR.sub.3 is (a) CH.sub.3,(b) C(CH.sub.3).sub.2 --(CH.sub.2).sub.n --CH.sub.3 where n is 0 through 17, or(c) substituents of the formula: ##STR2## where m is 0 through 10, and optionally(iv) at least 0.2% by weight of acrylic monomers containing at least one group having a reactive hydrogen, and (v) 0.01-2% by weight of a chelated metal alkoxide crosslinker to (i), (ii) and (iii).

    摘要翻译： 公开了用于透皮药物递送系统的压敏粘合剂组合物，其包含通过透皮药物制剂中包含的皮肤渗透增强剂耐受塑化的粘合剂组合物。 具体地说，本发明的压敏粘合剂组合物包含丙烯酸共聚物，其由以下组分制备：（i）至少40重量％的总单体组成的Tg为-90至0℃的丙烯酸烷基酯单体，（ii） 0-15％（重量）Tg为0-250℃的单体的总单体组成，和（iii）具有以下结构式的取代的丙烯酰胺或甲基丙烯酰胺的总单体组成的10-60重量％：其中 R1为H或CH3，R2为H或CH3，R3为（a）CH3，（b）C（CH3）2-（CH2）n-CH3，其中n为0至17，或（c） ：其中m为0至10，并且任选地（iv）至少0.2重量％的含有至少一个具有反应性氢的基团的丙烯酸单体，和（v）0.01-2重量％的螯合金属醇盐交联剂与（ i），（ii）和（iii）。

    Process for the continuous preparation of encapsulated toner
    7.
    发明授权
    Process for the continuous preparation of encapsulated toner 失效
    用于连续制备包封的调色剂的方法

    公开(公告)号：US5264315A

    公开(公告)日：1993-11-23

    申请号：US871156

    申请日：1992-04-20

    申请人： Hock S. Tan ,  Hadi K. Mahabadi ,  Joseph D. Wright

    发明人： Hock S. Tan ,  Hadi K. Mahabadi ,  Joseph D. Wright

    IPC分类号： B01J13/04 ,  B01J13/14 ,  B01J19/18 ,  G03G9/08 ,  G03G9/093

    CPC分类号： B01J19/1862 ,  G03G9/09392 ,  B01J2219/00099

    摘要： A process for the continuous preparation of an encapsulated toner comprised of a core comprised of polymer and pigment encapsulated within a polymer shell, which process comprises continuously separately feeding an oil phase containing core monomers, oil soluble shell monomers and pigment and an aqueous phase containing surfactant into a continuous flowthrough mixing tank; homogenizing the aforementioned two phases to enable small oil droplets with an average diameter of from between about 3 to about 25 microns; overflowing the resulting droplets to at least one continuously stirred tank reactor while simultaneously feeding water soluble shell monomer to said stirred reactor to effect interfacial polymerization thereby causing shell formation; and thereafter allowing the encapsulated droplets to flow into a reactor or reactors and heating the reactor or reactors to effect free radical polymerization of the core monomers, followed by cooling, and isolating the said encapsulated toner.

    摘要翻译： 用于连续制备包封的调色剂的方法包括由包封在聚合物外壳内的聚合物和颜料组成的芯，该方法包括连续分别进料含有核心单体，油溶性壳单体和颜料的油相和含水相的表面活性剂 进入连续流通的混合罐; 均化上述两相以使平均直径为约3至约25微米的小油滴; 将所得液滴溢流到至少一个连续搅拌的罐式反应器中，同时将水溶性壳单体加入到所述搅拌反应器中以进行界面聚合从而导致壳形成; 然后允许包封的液滴流入反应器或反应器并加热反应器或反应器以实现核心单体的自由基聚合，然后冷却，并分离所述包封的调色剂。