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公开(公告)号：US20200323788A1
公开(公告)日：2020-10-15
申请号：US16753471
申请日：2018-10-03
发明人： Suresh BORSADIA
IPC分类号： A61K9/70 , A61K31/485
摘要： Provided herein are transdermal delivery devices comprising dextromethorphan. The transdermal delivery device can be characterized by the novel design, for example, with an adhesive layer and a reservoir layer, with an adhesive layer comprising a mixture of two adhesives, and/or with a skin permeation enhancer, e.g., in an amount that can significantly enhance the flux of dextromethorphan. The transdermal delivery device can also be characterized by its in vitro and/or in vivo release profile, for example, that can provide a desired pharmacokinetic profile described herein. Also provided herein are methods of administering dextromethorphan, and methods of treating a disease or disorder described herein, using the transdermal delivery device herein.
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公开(公告)号：US20220362165A1
公开(公告)日：2022-11-17
申请号：US17770857
申请日：2020-10-21
发明人： Krunal RAVAL , Suresh BORSADIA , Hock S. TAN , Kalpana PATEL
IPC分类号： A61K9/70 , A61K31/4745
摘要： Provided herein are compositions, delivery devices, and methods relating to the delivery of tetrabenazine and/or deuterated tetrabenazine, for example, continuous or substantially continuous delivery such as transdermal delivery, for the treatment of a hyperkinetic movement disorder. Also provided are transdermal delivery devices comprising tetrabenazine, a deuterated tetrabenazine, or a combination thereof, pharmaceutical compositions comprising tetrabenazine and/or a deuterated tetrabenazine, methods of preparing the same, and methods of using the same for example, for the treatment of a hyperkinetic movement disorder.
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公开(公告)号：US20220331264A1
公开(公告)日：2022-10-20
申请号：US17858471
申请日：2022-07-06
发明人： Suresh BORSADIA
IPC分类号： A61K9/70 , A61K31/485
摘要： Provided herein are transdermal delivery devices comprising dextromethorphan. The transdermal delivery device can be characterized by the novel design, for example, with an adhesive layer and a reservoir layer, with an adhesive layer comprising a mixture of two adhesives, and/or with a skin permeation enhancer, e.g., in an amount that can significantly enhance the flux of dextromethorphan. The transdermal delivery device can also be characterized by its in vitro and/or in vivo release profile, for example, that can provide a desired pharmacokinetic profile described herein. Also provided herein are methods of administering dextromethorphan, and methods of treating a disease or disorder described herein, using the transdermal delivery device herein.
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公开(公告)号：US20240216358A1
公开(公告)日：2024-07-04
申请号：US17915687
申请日：2021-03-29
发明人： Suresh BORSADIA , Kalpana PATEL , Hock S. TAN , Krunal RAVAL
IPC分类号： A61K31/485 , A61K9/70 , A61K47/14 , A61K47/32
CPC分类号： A61K31/485 , A61K9/7061 , A61K9/7069 , A61K47/14 , A61K47/32
摘要： Provided herein are novel transdermal delivery devices (or patches) comprising dextromethorphan, pharmaceutical compositions comprising dextromethorphan, methods of preparation thereof, and methods of administering dextromethorphan transdermally. Also provided herein are methods of treating various diseases and disorders such as neurological diseases or disorders (e.g., PBA) using the transdermal delivery devices and/or pharmaceutical compositions herein.
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公开(公告)号：US11382869B2
公开(公告)日：2022-07-12
申请号：US16753471
申请日：2018-10-03
发明人： Suresh Borsadia
IPC分类号： A61K31/485 , A61K9/70 , A61P25/00
摘要： Provided herein are transdermal delivery devices comprising dextromethorphan. The transdermal delivery device can be characterized by the novel design, for example, with an adhesive layer and a reservoir layer, with an adhesive layer comprising a mixture of two adhesives, and/or with a skin permeation enhancer, e.g., in an amount that can significantly enhance the flux of dextromethorphan. The transdermal delivery device can also be characterized by its in vitro and/or in vivo release profile, for example, that can provide a desired pharmacokinetic profile described herein. Also provided herein are methods of administering dextromethorphan, and methods of treating a disease or disorder described herein, using the transdermal delivery device herein.
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公开(公告)号：US20210128490A1
公开(公告)日：2021-05-06
申请号：US17050230
申请日：2019-04-24
发明人： Suresh BORSADIA , Kalpana PATEL , Hock S. TAN
摘要： Provided herein are transdermal delivery devices comprising tetrabenazine, a deuterated tetrabenazine, or a combination thereof. Also provided herein are pharmaceutical compositions, such as adhesive compositions, comprising tetrabenazine, a deuterated tetrabenazine, or a combination thereof, for example, homogenously dispersed in an adhesive, such as a pressure sensitive adhesive. Further provided herein are methods of using the transdermal delivery devices or pharmaceutical compositions, for example, for treating a hyperkinetic movement disorder.
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