公开(公告)号：US08110654B2

公开(公告)日：2012-02-07

申请号：US12303244

申请日：2007-06-04

申请人： Heng Cui ,  Wei Li ,  Xiaohong Chang ,  Jie Feng ,  Hongyan Cheng ,  Huifang Guo ,  Yexia Cheng

发明人： Heng Cui ,  Wei Li ,  Xiaohong Chang ,  Jie Feng ,  Hongyan Cheng ,  Huifang Guo ,  Yexia Cheng

IPC分类号： A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  A61K38/04 ,  A61K38/10 ,  A61K38/08 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K2039/57

摘要： The present invention provides two T-cell epitode peptides of anti-idiotype antibody 6B11 of ovarian cancer, the sequences of which are shown in SEQ ID NO:3 or 6. The present invention also provides the use of such T-cell epitope peptides in the manufacture of vaccines against ovarian cancer and in the treatment and prevention of ovarian cancer. The T-cell epitope peptides of the present invention could specifically kill ovarian cancer cells which are OC166-9 positive, and could find a wide use in the treatment and prevention of ovarian cancer.

摘要翻译： 本发明提供两种卵巢癌抗独特型抗体6B11的T细胞上皮肽，其序列如SEQ ID NO：3或6所示。本发明还提供了这样的T细胞表位肽在 制造针对卵巢癌的疫苗以及治疗和预防卵巢癌。 本发明的T细胞表位肽可以特异性地杀死OC166-9阳性的卵巢癌细胞，可广泛用于治疗和预防卵巢癌。

公开(公告)号：US20090269366A1

公开(公告)日：2009-10-29

申请号：US12303244

申请日：2007-06-04

申请人： Heng Cui ,  Wei Li ,  Xiaohong Chang ,  Jie Feng ,  Hongyan Cheng ,  Huifang Guo ,  Yexia Cheng

发明人： Heng Cui ,  Wei Li ,  Xiaohong Chang ,  Jie Feng ,  Hongyan Cheng ,  Huifang Guo ,  Yexia Cheng

IPC分类号： A61K39/00 ,  C07K7/00 ,  C12N15/11 ,  C12N15/00 ,  A61K38/10 ,  G01N33/68

CPC分类号： A61K39/0011 ,  A61K2039/57

摘要： The present invention provides two T-cell epitode peptides of anti-idiotype antibody 6B11 of ovarian cancer, the sequences of which are shown in SEQ ID NO:3 or 6. The present invention also provides the use of such T-cell epitope peptides in the manufacture of vaccines against ovarian cancer and in the treatment and prevention of ovarian cancer. The T-cell epitope peptides of the present invention could specifically kill ovarian cancer cells which are OC166-9 positive, and could find a wide use in the treatment and prevention of ovarian cancer.

摘要翻译： 本发明提供两种卵巢癌抗独特型抗体6B11的T细胞上皮肽，其序列如SEQ ID NO：3或6所示。本发明还提供了这样的T细胞表位肽在 制造针对卵巢癌的疫苗以及治疗和预防卵巢癌。 本发明的T细胞表位肽可以特异性地杀死OC166-9阳性的卵巢癌细胞，可广泛用于治疗和预防卵巢癌。