利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.012 秒)

    Fluorescent silica-based nanoparticles
    1.
    发明授权
    Fluorescent silica-based nanoparticles 有权
    荧光二氧化硅基纳米粒子

    公开(公告)号：US08298677B2

    公开(公告)日：2012-10-30

    申请号：US10536569

    申请日：2003-11-26

    申请人： Ulrich Wiesner ,  Hooisweng Ow ,  Daniel R. Larson ,  Watt W. Webb

    发明人： Ulrich Wiesner ,  Hooisweng Ow ,  Daniel R. Larson ,  Watt W. Webb

    IPC分类号： B32B19/00 ,  B32B17/00

    CPC分类号： C09K11/025 ,  B82Y30/00 ,  C01B33/18 ,  C01P2002/80 ,  C01P2004/03 ,  C01P2004/64 ,  C07K16/00 ,  C07K2317/52 ,  C09K11/06 ,  G01N33/5005 ,  G01N33/54346 ,  G01N33/582 ,  G01N33/587 ,  Y10T428/2438 ,  Y10T428/31663

    摘要： The invention generally relates to fluorescent nanoparticles and more specifically to silica-based fluorescent nanoparticles of less than 30 nm with covalently attached organic dyes. The invention provides a fluorescent monodisperse silica nanoparticle comprising fluorophore center core and a silica shell wherein the radiative properties of the nanoparticle are dependent upon the chemistry (composition) of the core and presence of the silica shell. In one aspect of the invention, the core-shell architecture provides an enhancement in fluorescence quantum efficiency. The invention generally provides control of photophysical properties of dye molecules encapsulated within silica particles with sizes down to 30 nm and below. This control is accomplished through changes in silica chemistry and particle architecture on the nanometer size scale and results in significant brightness enhancement compared to free dye.

    摘要翻译： 本发明通常涉及荧光纳米颗粒，更具体地涉及小于30nm的具有共价连接的有机染料的二氧化硅基荧光纳米颗粒。 本发明提供了包含荧光团中心核和二氧化硅壳的荧光单分散二氧化硅纳米颗粒，其中纳米颗粒的辐射性质取决于核的化学（组成）和二氧化硅壳的存在。 在本发明的一个方面，核 - 壳结构提供荧光量子效率的增强。 本发明通常提供了封装在尺寸低至30nm及以下的二氧化硅颗粒内的染料分子的光物理性质的控制。 这种控制是通过二氧化硅化学和粒子结构在纳米尺度尺度上的变化来实现的，并且与游离染料相比导致显着的亮度增强。

    Fluorescent silica-based nanoparticles
    2.
    发明授权
    Fluorescent silica-based nanoparticles 有权
    荧光二氧化硅基纳米粒子

    公开(公告)号：US08409876B2

    公开(公告)日：2013-04-02

    申请号：US12579302

    申请日：2009-10-14

    申请人： Ulrich B. Wiesner ,  Hooisweng Ow

    发明人： Ulrich B. Wiesner ,  Hooisweng Ow

    IPC分类号： G01N33/551 ,  B32B19/00

    CPC分类号： C09K11/025 ,  B82Y30/00 ,  C01B33/18 ,  C01P2002/80 ,  C01P2004/03 ,  C01P2004/64 ,  C07K16/00 ,  C07K2317/52 ,  C09K11/06 ,  G01N33/5005 ,  G01N33/54346 ,  G01N33/582 ,  G01N33/587 ,  Y10T428/2438 ,  Y10T428/31663

    摘要： The present invention provides nanoparticle compositions comprising, for example, a core comprising a fluorescent silane compound; and a silica shell on the core. Also provided are methods for the preparation of nanoparticle compositions including fluorescent nanoparticles, ligated-fluorescent nanoparticles, ligated-fluorescent nanoparticles having therapeutic agents, and ligated-fluorescent nanoparticles coupled or associated with an analyte. Also provided are methods: for the detection of the ligated-fluorescent nanoparticles; for associating the linked-fluorescent nanoparticles with a cellular component of interest and recording or monitoring the movement of the cellular component; for improving the therapeutic properties of the therapeutic agent by combining the therapeutic agent with linked-fluorescent nanoparticles and contacting or administering the combination to a cell or organism; for making and using the fluorescent nanoparticles in, for example, diagnostic agents for the detection of various analytes, and like applications.

    摘要翻译： 本发明提供了纳米颗粒组合物，其包含例如包含荧光硅烷化合物的核心; 和核心上的二氧化硅壳。 还提供了制备纳米颗粒组合物的方法，包括荧光纳米颗粒，连接荧光纳米颗粒，具有治疗剂的连接荧光纳米颗粒，以及与分析物偶联或结合的连接荧光纳米颗粒。 还提供了用于检测连接的荧光纳米颗粒的方法： 用于将所述连接的荧光纳米颗粒与感兴趣的细胞组分结合，并记录或监测细胞组分的运动; 用于通过将治疗剂与连接的荧光纳米颗粒组合并将组合接触或施用于细胞或生物体来改善治疗剂的治疗性质; 用于在例如用于检测各种分析物的诊断剂等的应用中制造和使用荧光纳米颗粒。

    PEG-COATED CORE-SHELL SILICA NANOPARTICLES AND METHODS OF MANUFACTURE AND USE
    3.
    发明申请
    PEG-COATED CORE-SHELL SILICA NANOPARTICLES AND METHODS OF MANUFACTURE AND USE 审中-公开
    PEG涂层核心二氧化硅纳米粒子及其制造和使用方法

    公开(公告)号：US20110028662A1

    公开(公告)日：2011-02-03

    申请号：US12675210

    申请日：2008-08-29

    申请人： Ulrich Wiesner ,  Hooisweng Ow

    发明人： Ulrich Wiesner ,  Hooisweng Ow

    IPC分类号： C08G77/00

    CPC分类号： C09K11/025 ,  A61K49/0032 ,  A61K49/0093 ,  C09K11/06

    摘要： Described herein are PEG-coated, core-shell nanoparticles, which display reduced aggregation and/or reduced non-specific or undesired attachment characteristics. These fluorescent nanoparticle include: a silica-based core having an organic functional group that includes a mercapto substituent, an organic fluorescent compound, a silica shell; and a silane-PEG compound. The silica shell of the nanoparticle encapsulates the silica-based core and the silane-PEG compound is conjugated to the silica shell.

    摘要翻译： 本文描述的是PEG-包覆的核 - 壳纳米颗粒，其显示减少的聚集和/或降低的非特异性或不期望的附着特征。 这些荧光纳米粒子包括：具有巯基取代基的有机官能团的二氧化硅系核心，有机荧光化合物，二氧化硅壳; 和硅烷-PEG化合物。 纳米颗粒的二氧化硅壳包封二氧化硅基核，硅烷-PEG化合物与二氧化硅壳结合。

    Fluorescent Silica-Based Nanoparticles
    6.
    发明申请
    Fluorescent Silica-Based Nanoparticles 有权
    荧光二氧化硅基纳米颗粒

    公开(公告)号：US20100035365A1

    公开(公告)日：2010-02-11

    申请号：US12579302

    申请日：2009-10-14

    申请人： Ulrich Wiesner ,  Hooisweng Ow

    发明人： Ulrich Wiesner ,  Hooisweng Ow

    IPC分类号： G01N33/566

    CPC分类号： C09K11/025 ,  B82Y30/00 ,  C01B33/18 ,  C01P2002/80 ,  C01P2004/03 ,  C01P2004/64 ,  C07K16/00 ,  C07K2317/52 ,  C09K11/06 ,  G01N33/5005 ,  G01N33/54346 ,  G01N33/582 ,  G01N33/587 ,  Y10T428/2438 ,  Y10T428/31663

    摘要： The present invention provides nanoparticle compositions comprising, for example, a core comprising a fluorescent silane compound; and a silica shell on the core. Also provided are methods for the preparation of nanoparticle compositions including fluorescent nanoparticles, ligated-fluorescent nanoparticles, ligated-fluorescent nanoparticles having therapeutic agents, and ligated-fluorescent nanoparticles coupled or associated with an analyte. Also provided are methods: for the detection of the ligated-fluorescent nanoparticles; for associating the linked-fluorescent nanoparticles with a cellular component of interest and recording or monitoring the movement of the cellular component; for improving the therapeutic properties of the therapeutic agent by combining the therapeutic agent with linked-fluorescent nanoparticles and contacting or administering the combination to a cell or organism; for making and using the fluorescent nanoparticles in, for example, diagnostic agents for the detection of various analytes, and like applications.

    摘要翻译： 本发明提供了纳米颗粒组合物，其包含例如包含荧光硅烷化合物的核心; 和核心上的二氧化硅壳。 还提供了制备纳米颗粒组合物的方法，包括荧光纳米颗粒，连接荧光纳米颗粒，具有治疗剂的连接荧光纳米颗粒，以及与分析物偶联或相关联的连接荧光纳米颗粒。 还提供了用于检测连接的荧光纳米颗粒的方法： 用于将所述连接的荧光纳米颗粒与感兴趣的细胞组分结合，并记录或监测细胞组分的运动; 用于通过将治疗剂与连接的荧光纳米颗粒组合并将组合接触或施用于细胞或生物体来改善治疗剂的治疗性质; 用于在例如用于检测各种分析物的诊断剂等的应用中制造和使用荧光纳米颗粒。