公开(公告)号：US06983176B2

公开(公告)日：2006-01-03

申请号：US09832608

申请日：2001-04-11

申请人： Craig Gardner ,  Michael J. Haass ,  Robert K. Rowe ,  Howland Jones ,  Steven T. Strohl ,  Matthew J. Novak ,  Russell E. Abbink ,  David Nuñez ,  William Gruner ,  Robert D. Johnson

发明人： Craig Gardner ,  Michael J. Haass ,  Robert K. Rowe ,  Howland Jones ,  Steven T. Strohl ,  Matthew J. Novak ,  Russell E. Abbink ,  David Nuñez ,  William Gruner ,  Robert D. Johnson

IPC分类号： A61B5/00

CPC分类号： G01N21/278 ,  A61B5/0075

摘要： Systems and methods for establishing and/or maintaining the prediction capability over time of a multivariate calibration model designed for quantitative optical spectroscopic measurement of attributes or analytes in bodily tissues, bodily fluids or other biological samples, which are particularly useful when the spectral absorbance of the attribute or analyte is small relative to the background. The present invention provides an optically similar reference sample to capture the characteristics of instrument and environmental variation and to reduce the effect of such variation on the measurement capability of the model. The optically similar reference is preferably stable over time and is designed such that its optical properties are sufficiently matched to the sample of interest that instrument and environmental variations are captured in the same manner in both the test sample of interest and the optically similar reference sample. The optically similar reference sample may include one or more physical components which are spectroscopically measured in a manner which closely mimics the spectroscopic measurement of the test sample of interest. Spectral similarity may also be achieved by using alternative components with spectral characteristics similar to the components contained in the test sample of interest.

公开(公告)号：US20050280813A1

公开(公告)日：2005-12-22

申请号：US11153596

申请日：2005-06-15

申请人： Howland Jones ,  Mark Robinson ,  Robert Johnson ,  Cliona Fleming ,  Christepher Brown

发明人： Howland Jones ,  Mark Robinson ,  Robert Johnson ,  Cliona Fleming ,  Christepher Brown

IPC分类号： G01J3/00 ,  G01J3/10 ,  G01N21/25 ,  G01N21/35

CPC分类号： G01J3/108 ,  G01N21/253 ,  G01N21/3563

摘要： The present invention provides a method for using infrared light either alone or in conjunction with visible light to create an improved system for cytologic examination. As stated above, infrared light is sensitive to molecular and biochemical changes and can thus be used to identify specific chemical species or substances. This characteristic can be used to identify areas on a slide most likely to contain an abnormality, and can further provide information to overlay on an image of the slide to enhance the visual contrast for the human screener. This process of image enhancement via the use of multivariate spectroscopy can be used to dramatically enhance the information content provided to the medical professional.

摘要翻译： 本发明提供了单独或与可见光结合使用红外光的方法，以创建改进的细胞学检查系统。 如上所述，红外光对分子和生物化学变化敏感，因此可用于鉴定特定的化学物质或物质。 该特征可以用于识别最可能包含异常的幻灯片上的区域，并且可以进一步提供信息以覆盖在幻灯片的图像上，以增强人类筛选器的视觉对比度。 通过使用多变量光谱法，该图像增强过程可用于显着增强提供给医疗专业人员的信息内容。

公开(公告)号：US07027848B2

公开(公告)日：2006-04-11

申请号：US10116269

申请日：2002-04-04

申请人： Mark Ries Robinson ,  Cliona Fleming ,  Howland Jones ,  Mark Rohrscheib

发明人： Mark Ries Robinson ,  Cliona Fleming ,  Howland Jones ,  Mark Rohrscheib

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/1495

摘要： A method is provided for building improved calibration models or for improving modifications to these models or validation of the models used in the non-invasive spectroscopic measurement of an analyte or attribute of tissue. The method uses a matched reference sample and measurement of that sample to ensure that the correct relationship between the spectra and analyte is made during the model building, modification or calibration process. A matched reference sample is one in which the analyte of interest or attribute of interest in the reference sample is representative of the analyte or attribute at the site being non-invasively sampled or the agreement between the reference concentration and the non-invasively sampled concentration is clinically significant.