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    Encoded variable filter spectrometer
    3.
    发明授权
    Encoded variable filter spectrometer 失效
    编码变量滤光片

    公开(公告)号：US07126682B2

    公开(公告)日：2006-10-24

    申请号：US09832631

    申请日：2001-04-11

    申请人： Robert K. Rowe ,  Russell E. Abbink ,  Stephan P. Corcoran

    发明人： Robert K. Rowe ,  Russell E. Abbink ,  Stephan P. Corcoran

    IPC分类号： G01J3/04

    CPC分类号： G01J3/10 ,  G01J3/0218 ,  G01J3/12 ,  G01J3/32 ,  G01J2003/123 ,  G01J2003/1234 ,  G01N21/255

    摘要： Spectroscopic system and spectrometers including an optical bandpass filter unit having a plurality of bandpass regions and a spatial encoding unit for encoding discrete frequencies of light passing through the optical filter. The incorporation of the encoding unit allows the spectrometer system to use a detector having one or a small number of elements, rather than using a more expensive detector array typically used with filter-based spectrometers. The system can also include an integrating chamber that collects the light that is not transmitted through the bandpass filter unit, and redirects this light to strike the filter unit again, resulting in a significant increase in the optical power passing through the filter. The integrating chamber maximizes the return of the reflected light to the filter assembly and minimizes optical losses. The integrating chamber may be an orthogonal design to preserve the optical geometric characteristics of the light entering the chamber.

    摘要翻译： 光谱系统和光谱仪包括具有多个带通区的光学带通滤波器单元和用于编码通过滤光器的光的离散频率的空间编码单元。 编码单元的结合允许光谱仪系统使用具有一个或少量元件的检测器，而不是使用通常与基于滤光器的光谱仪一起使用的更昂贵的检测器阵列。 该系统还可以包括积分室，其收集不透过带通滤光器单元的光，并且重新定向该光以再次撞击过滤器单元，导致通过过滤器的光功率的显着增加。 积分室使反射光的返回最大化到滤光器组件，并使光损耗最小化。 积分室可以是正交设计，以保持进入室的光的光学几何特性。

    Methods and Apparatuses for Noninvasive Determinations of Analytes
    4.
    发明申请
    Methods and Apparatuses for Noninvasive Determinations of Analytes 有权
    无创测定分析物的方法和设备

    公开(公告)号：US20140303463A1

    公开(公告)日：2014-10-09

    申请号：US14250125

    申请日：2014-04-10

    申请人： M. Ries Robinson ,  Russell E. Abbink ,  Robert D. Johnson

    发明人： M. Ries Robinson ,  Russell E. Abbink ,  Robert D. Johnson

    IPC分类号： A61B5/1455 ,  A61B5/145

    CPC分类号： A61B5/14552 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14558 ,  A61B5/7257 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0262 ,  G01N21/21 ,  G01N21/49 ,  G01N2021/4792

    摘要： The present invention provides methods and apparatuses for accurate noninvasive determination of tissue properties. Some embodiments of the present invention comprise an optical sampler having an illumination subsystem, adapted to communicate light having a first polarization to a tissue surface; a collection subsystem, adapted to collect light having a second polarization communicated from the tissue after interaction with the tissue; wherein the first polarization is different from the second polarization. The difference in the polarizations can discourage collection of light specularly reflected from the tissue surface, and can encourage preferential collection of light that has interacted with a desired depth of penetration or path length distribution in the tissue. The different polarizations can, as examples, be linear polarizations with an angle between, or elliptical polarizations of different handedness.

    摘要翻译： 本发明提供用于精确无创确定组织性质的方法和装置。 本发明的一些实施例包括具有照明子系统的光学采样器，适于将具有第一偏振光的光传送到组织表面; 收集子系统，适于在与所述组织相互作用之后收集从所述组织传递的具有第二极化的光; 其中所述第一极化不同于所述第二极化。 极化的差异可以阻止从组织表面反射的光的收集，并且可以鼓励优先收集与组织中所需的穿透深度或路径长度分布相互作用的光。 作为示例，不同的极化可以是具有不同手性的角度或椭圆偏振之间的线性偏振。

    Apparatus and method for reducing spectral complexity in optical sampling
    6.
    发明授权
    Apparatus and method for reducing spectral complexity in optical sampling 失效
    减少光学采样中光谱复杂度的装置和方法

    公开(公告)号：US06684099B2

    公开(公告)日：2004-01-27

    申请号：US10116271

    申请日：2002-04-04

    申请人： Trent Ridder ,  John D. Maynard ,  Russell E. Abbink ,  Robert D. Johnson

    发明人： Trent Ridder ,  John D. Maynard ,  Russell E. Abbink ,  Robert D. Johnson

    IPC分类号： A61B505

    CPC分类号： A61B5/0059 ,  A61B5/6824

    摘要： An optical sampling subsystem and method that reduces the effect of errors in an optical sampling subsystem when heterogeneously distributed samples are measured in the path of a spectrometer. The optical sampling subsystem is used to collect the non-uniformly distributed radiation exiting the heterogeneous sample and produce a uniform irradiance at its output. The output is then directed into the wavenumber (inverse of wavelength in centimeters) dispersive or modulating device of the spectrometer. The resulting spectra exhibit less spectral complexity arising from components of the sampling subsystem design and the heterogeneous sample, in particular, the effect of wavenumber shift is minimized. Improved quantitative predictions, qualitative analysis and calibration transfer are direct consequences of the reduced spectral complexity.

    摘要翻译： 当在光谱仪的路径中测量非均匀分布的样本时，光采样子系统和方法可减少光采样子系统中误差的影响。 光采样子系统用于收集离散异质样品的非均匀分布的辐射，并在其输出端产生均匀的辐照度。 然后将输出引导到光谱仪的波数（以厘米为单位的波长的倒数）色散或调制装置。 所得到的光谱表现出较小的光谱复杂度，由采样子系统设计和异质样本的组成部分引起，特别是波数偏移的影响被最小化。 改进的定量预测，定性分析和校准转移是降低光谱复杂度的直接后果。

    Methods and Apparatuses for Noninvasive Determinations of Analytes
    7.
    发明申请
    Methods and Apparatuses for Noninvasive Determinations of Analytes 审中-公开
    无创测定分析物的方法和设备

    公开(公告)号：US20110184260A1

    公开(公告)日：2011-07-28

    申请号：US13036012

    申请日：2011-02-28

    申请人： M. Ries Robinson ,  Russell E. Abbink ,  Robert D. Johnson

    发明人： M. Ries Robinson ,  Russell E. Abbink ,  Robert D. Johnson

    IPC分类号： A61B5/1455

    CPC分类号： G01N21/21 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14558 ,  A61B5/7257 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0262 ,  G01N21/49 ,  G01N2021/4792

    摘要： The present invention provides methods and apparatuses for accurate noninvasive determination of tissue properties. Some embodiments of the present invention comprise an optical sampler having an illumination subsystem, adapted to communicate light having a first polarization to a tissue surface; a collection subsystem, adapted to collect light having a second polarization communicated from the tissue after interaction with the tissue; wherein the first polarization is different from the second polarization. The difference in the polarizations can discourage collection of light specularly reflected from the tissue surface, and can encourage preferential collection of light that has interacted with a desired depth of penetration or path length distribution in the tissue. The different polarizations can, as examples, be linear polarizations with an angle between, or elliptical polarizations of different handedness.

    摘要翻译： 本发明提供用于精确无创确定组织性质的方法和装置。 本发明的一些实施例包括具有照明子系统的光学采样器，适于将具有第一偏振光的光传送到组织表面; 收集子系统，适于在与所述组织相互作用之后收集从所述组织传递的具有第二极化的光; 其中所述第一极化不同于所述第二极化。 极化的差异可以阻止从组织表面反射的光的收集，并且可以鼓励优先收集与组织中所需的穿透深度或路径长度分布相互作用的光。 作为示例，不同的极化可以是具有不同手性的角度或椭圆偏振之间的线性偏振。

    Alignment System for Optically Sampling a Hand
    10.
    发明申请
    Alignment System for Optically Sampling a Hand 审中-公开
    用于光学取样的对准系统

    公开(公告)号：US20100113899A1

    公开(公告)日：2010-05-06

    申请号：US12614056

    申请日：2009-11-06

    申请人： Mark Ries Robinson ,  Andrea Magee ,  Michael U. Haass ,  Russell E. Abbink ,  William Radigan ,  V. Gerald Grafe

    发明人： Mark Ries Robinson ,  Andrea Magee ,  Michael U. Haass ,  Russell E. Abbink ,  William Radigan ,  V. Gerald Grafe

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/6825 ,  A61B5/6826 ,  A61B5/6838

    摘要： This invention relates to measurements of material properties by determination of the response of a sample to incident radiation, and more specifically to the measurement of analytes such as glucose or alcohol in human tissue. Some example embodiments of the present invention provide an optical sampling apparatus including an optical subsystem, having a receiver for receiving light expressed from tissue; and an alignment subsystem, adapted to urge a portion of a hand placed in operative relationship with the alignment subsystem into a defined configuration relative to the receiver. In some such example embodiments, the alignment subsystem includes a substrate having a plurality of projections therefrom disposed in a pattern such that the projections urge a portion of a hand placed on the substrate to a defined configuration relative to the receiver. In some such example embodiments, the alignment subsystem includes a substrate having a surface defining a volume approximating the shape of a portion of a hand such that the volume urges a portion of a hand placed therein to a defined configuration relative to the receiver. In some such example embodiments, the alignment subsystem includes a surface having a generally U-shaped cross-section and extending for a distance, wherein the surface is mounted relative to the sampling means such that a finger placed in the U-shaped cross-section of the surface is urged to a defined configuration relative to the receiver. In some such sample embodiments, the alignment subsystem is customized to portion of the hand of a specific individual.

    摘要翻译： 本发明涉及通过测定样品对入射辐射的响应，更确切地说，涉及人体组织中分析物如葡萄糖或醇的测量来测量材料性质。 本发明的一些示例性实施例提供一种包括光学子系统的光采样装置，其具有用于接收从组织表达的光的接收器; 以及对准子系统，其适于将与所述对准子系统处于可操作关系的手的一部分相对于所述接收器推定为限定的配置。 在一些这样的示例性实施例中，对准子系统包括具有多个突起的衬底，该突出部设置成图案，使得突起将放置在衬底上的手的一部分相对于接收器推压到限定的构型。 在一些这样的示例性实施例中，对准子系统包括具有限定近似手部的形状的体积的表面的衬底，使得该体积将其中放置的手的一部分相对于接收器施加到限定的构型。 在一些这样的示例性实施例中，对准子系统包括具有大致U形横截面并延伸一定距离的表面，其中相对于采样装置安装表面，使得手指放置在U形横截面 的表面被推动到相对于接收器的限定的配置。 在一些这样的示例性实施例中，对准子系统被定制为特定个体的手的部分。