公开(公告)号：US06384085B1

公开(公告)日：2002-05-07

申请号：US09629342

申请日：2000-08-01

Applicant: Bong-Ho Lee ,  Byung-Wook Choi ,  Geon-Seek Ryu ,  Sang-Keun Kim ,  Hyeon-Cheol Shin

Inventor： Bong-Ho Lee ,  Byung-Wook Choi ,  Geon-Seek Ryu ,  Sang-Keun Kim ,  Hyeon-Cheol Shin

IPC: A61K3105

CPC classification number: A61K31/357

Abstract: Disclosed are novel materials separated from Ecklonia cava, a method for extracting and purifying the same, and the use thereof for antioxidants. The method comprises extracting antioxidative ingredients from powdered Ecklonia cava one or more times with an organic solvent; fractionating the antioxidative ingredients one or more times in solvents; and purifying the solvent fractions by chromatography. Superior in scavenging activity and thermal stability, the extract from Ecklonia cava can be used as antioxidants and is suitable in commercialization.

Abstract translation: 公开了从Ecklonia cava分离的新型材料，其提取和纯化方法，以及其用于抗氧化剂的用途。 该方法包括用有机溶剂一次或多次从粉状的Ecklonia cava提取抗氧化成分; 将抗氧化成分在溶剂中分一次或多次; 并通过色谱法纯化溶剂级分。 清澈活性和热稳定性优异，Ecklonia cava的提取物可用作抗氧化剂，适用于商业化。

公开(公告)号：US20120122822A1

公开(公告)日：2012-05-17

申请号：US12948054

申请日：2010-11-17

Applicant: Bong-Ho LEE ,  Seongho KIM ,  Hyeon-Cheol SHIN ,  Haengwoo LEE

Inventor： Bong-Ho LEE ,  Seongho KIM ,  Hyeon-Cheol SHIN ,  Haengwoo LEE

IPC: A61K31/60 ,  A61K31/55 ,  A61K31/335 ,  A61P25/28 ,  A61K31/365 ,  A61K31/42 ,  A61K31/352 ,  A61P25/00 ,  C07D311/78 ,  A61K31/415

CPC classification number: A61K31/357 ,  A61K31/05 ,  A61K31/192 ,  A61K31/352 ,  A61K31/353 ,  A61K31/415 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/635 ,  A61K45/06 ,  C07D493/04 ,  A61K2300/00

Abstract: Disclosed are a composition for reducing beta amyloid-induced neurotoxicity by inhibiting β-secretase activity, comprising a dibenzofuran derivative, and a method for preparing the same. Further disclosed is that the combination of the dibenzofuran derivative with a γ-secretase inhibitor or an anti-inflammatory agent shows higher activity with respect to reducing beta amyloid-induced neurotoxicity.

Abstract translation: 公开了一种通过抑制β-分泌酶活性降低β淀粉样蛋白诱导的神经毒性的组合物，其包含二苯并呋喃衍生物及其制备方法。 进一步公开的是，二苯并呋喃衍生物与γ-分泌酶抑制剂或抗炎剂的组合在降低β-淀粉样蛋白诱导的神经毒性方面表现出较高的活性。

公开(公告)号：US20100184847A1

公开(公告)日：2010-07-22

申请号：US12670062

申请日：2008-07-30

Applicant: Hyeon-Cheol Shin ,  Hye-Jeong Hwang

Inventor： Hyeon-Cheol Shin ,  Hye-Jeong Hwang

IPC: A61K31/335 ,  C07D319/14 ,  A61K8/49 ,  A61Q19/00 ,  A61Q19/08 ,  A61P17/00

CPC classification number: A61K8/498 ,  A61Q19/08

Abstract: The present invention relates to compositions for skin protection and improvement that contain dibenzo-p-dioxine derivatives as effective components. Since the compositions for skin protection and improvement that contain the dibenzo-p-dioxine derivative according to the present invention have excellent functions such as moisturizing and/or wrinkle prevention which are useful in prevention and improvement of various skin diseases, they can be extensively used as cosmetic ingredients or pharmaceutical agents for prevention and improvement of skin diseases.

Abstract translation: 本发明涉及含有二苯并对二恶英衍生物作为有效成分的皮肤保护和改善用组合物。 由于含有本发明的二苯并对二恶英衍生物的皮肤保护和改善用组合物具有优异的功能，如保湿和/或防皱，可用于预防和改善各种皮肤病，因此可广泛使用 作为用于预防和改善皮肤疾病的化妆品成分或药剂。

公开(公告)号：US06774145B1

公开(公告)日：2004-08-10

申请号：US09629341

申请日：2000-08-01

Applicant: Bong-Ho Lee ,  Byung-Wook Choi ,  Geon-Seek Ryu ,  Sang-Keun Kim ,  Hyeon-Cheol Shin

Inventor： Bong-Ho Lee ,  Byung-Wook Choi ,  Geon-Seek Ryu ,  Sang-Keun Kim ,  Hyeon-Cheol Shin

IPC: A61K3103

CPC classification number: A61K31/343 ,  A61K36/05

Abstract: Disclosed are novel materials separated from Ecklonia cava, a method for extracting and purifying the same, and the use thereof for antioxidants. The method comprises extracting antioxidative ingredients from powdered Ecklonia cava one or more times with an organic solvent; fractionating the antioxidative ingredients one or more times in solvents; and purifying the solvent fractions by chromatography. Superior in scavenging activity and thermal stability, the extract from Ecklonia cava can be used as antioxidants and is suitable in commercialization.

Abstract translation: 公开了从Ecklonia cava分离的新型材料，其提取和纯化方法，以及其用于抗氧化剂的用途。 该方法包括用有机溶剂一次或多次从粉状的Ecklonia cava提取抗氧化成分; 将抗氧化成分在溶剂中分一次或多次; 并通过色谱法纯化溶剂级分。 清澈活性和热稳定性优异，Ecklonia cava的提取物可用作抗氧化剂，适用于商业化。

公开(公告)号：US06221975B1

公开(公告)日：2001-04-24

申请号：US09377305

申请日：1999-08-19

Applicant: Hyeon Cheol Shin ,  Chang Hwan Lee

Inventor： Hyeon Cheol Shin ,  Chang Hwan Lee

IPC: C08F837

CPC classification number: C08F8/32

Abstract: This invention relates to a polymer having functional groups at both terminals comprising the steps of: preparing a difunctional initiator by recating divinyl aromatic material and an organo-lithium compound in the presence of a hydrocarbon solvent; synthesizing a random copolymer derived from an aromatic vinyl and conjugated diene monomer at only one terminal of two anionic terminals; adding a polar additive to activate both terminals of said copolymer, followed by the addition of an electrophilic material. The polymer material, so prepared, has an excellent combination of properties such as improved rolling resistance for use in making tire rubber treads, since it can enhance the polymer-filler interaction.

Abstract translation: 本发明涉及在两端具有官能团的聚合物，其包括以下步骤：通过在烃溶剂存在下重新提取二乙烯基芳族物质和有机锂化合物来制备双官能引发剂; 合成来自芳族乙烯基和共轭二烯单体的无规共聚物仅在两个阴离子末端的一个末端; 加入极性添加剂以活化所述共聚物的两个末端，然后加入亲电材料。 如此制备的聚合物材料具有优异的性能组合，例如用于制造轮胎橡胶胎面的改善的滚动阻力，因为它可以增强聚合物 - 填料相互作用。

公开(公告)号：US5994476A

公开(公告)日：1999-11-30

申请号：US114842

申请日：1998-07-14

Applicant: Hyeon-Cheol Shin ,  Jin-Kyung Kim ,  Jong-Geun Kim

Inventor： Hyeon-Cheol Shin ,  Jin-Kyung Kim ,  Jong-Geun Kim

IPC: C08F279/00 ,  C08F2/60 ,  C08F297/04 ,  C08F12/08 ,  C08F212/08

CPC classification number: C08F297/04

Abstract: This invention relates to a process for preparing a block copolymer composition, wherein it comprises following successive steps:a step in which a vinyl aromatic monomer is polymerized in a reactor in the presence of an inert hydrocarbon solvent and organolithium initiator until depletion of the monomer to generate a living polymer; a step in which a conjugated diene monomer is added to the above polymer to synthesize a living diblock copolymer; a step in which a portion of polymerization terminator is added to partially inactivate the living diblock copolymer; steps in which a conjugated diene monomer and aromatic vinyl monomer are sequentially added to generate a mixture of living triblock copolymer and inactivated diblock copolymer; a step in which a polymerization terminator is added to complete the reaction.This invention has advantages of providing easy, wide-range and fine control of block copolymer compositions in a reactor via well-controlled termination reactions during the sequential block copolymerization.

Abstract translation: 本发明涉及一种制备嵌段共聚物组合物的方法，其中包括以下连续步骤：在惰性烃溶剂和有机锂引发剂存在下，在反应器中聚合乙烯基芳族单体直到单体耗尽 生成活性聚合物; 将共轭二烯单体加入到上述聚合物中以合成活性二嵌段共聚物的步骤; 加入一部分聚合终止剂以部分灭活活性二嵌段共聚物的步骤; 依次加入共轭二烯单体和芳族乙烯基单体以产生活性三嵌段共聚物和失活的二嵌段共聚物的混合物的步骤; 加入聚合终止剂以完成反应的步骤。 本发明的优点是在顺序嵌段共聚期间通过良好控制的终止反应在反应器中提供容易的，宽范围和精细的嵌段共聚物组合的控制。

公开(公告)号：US20120122965A1

公开(公告)日：2012-05-17

申请号：US13297828

申请日：2011-11-16

Applicant: Hyeon-Cheol Shin ,  Hye-Jeong Hwang

Inventor： Hyeon-Cheol Shin ,  Hye-Jeong Hwang

IPC: A61K8/49 ,  A61Q19/00 ,  A61Q19/08

CPC classification number: A61K8/498 ,  A61Q19/08

Abstract: The present invention relates to compositions for skin protection and improvement that contain dibenzo-p-dioxine derivatives as effective components.Since the compositions for skin protection and improvement that contain the dibenzo-p-dioxine derivative according to the present invention have excellent functions such as moisturizing and/or wrinkle prevention which are useful in prevention and improvement of various skin diseases, they can be extensively used as cosmetic ingredients or pharmaceutical agents for prevention and improvement of skin diseases.

Abstract translation: 本发明涉及含有二苯并对二恶英衍生物作为有效成分的皮肤保护和改善用组合物。 由于含有本发明的二苯并对二恶英衍生物的皮肤保护和改善用组合物具有优异的功能，如保湿和/或防皱，可用于预防和改善各种皮肤病，因此可广泛使用 作为用于预防和改善皮肤疾病的化妆品成分或药剂。

公开(公告)号：US20110091532A1

公开(公告)日：2011-04-21

申请号：US12996603

申请日：2009-04-17

Applicant: Haeng Woo Lee ,  Hyeon Cheol Shin ,  Seoung Ho Kim ,  Yong Ju Park

Inventor： Haeng Woo Lee ,  Hyeon Cheol Shin ,  Seoung Ho Kim ,  Yong Ju Park

IPC: A61K31/357 ,  A61K9/127 ,  A61P19/02

CPC classification number: C07D493/04 ,  A61K9/127 ,  A61K31/357 ,  C07D319/24 ,  C07D407/12

Abstract: Disclosed is a composition for treating arthritis containing a dibenzo-p-dioxin derivative as an active ingredient. This dibenzo-p-dioxin derivative is very effective in inhibiting NF-kB and AP-1 activity, alleviates the symptoms of degenerative arthritis and rheumatoid arthritis without irritating the skin or causing side effects, and can continue to exhibit improvement effects for a considerable period of time after discontinuation of treatment. Additionally, when the dibenzo-p-dioxin derivative is contained in liposomes, the composition of the invention exhibits much greater effects on treating arthritis by absorption through skin, and thus is useful for the treatment of degenerative arthritis and rheumatoid arthritis.

Abstract translation: 公开了用于治疗含有二苯并对二恶英衍生物作为活性成分的关节炎的组合物。 这种二苯并对二恶英衍生物在抑制NF-kB和AP-1活性方面非常有效，缓解了退行性关节炎和类风湿关节炎的症状，而不会刺激皮肤或引起副作用，并且可以在相当长的一段时间内继续表现出改善作用 的时间停止治疗。 此外，当二苯并对二恶英衍生物包含在脂质体中时，本发明的组合物通过皮肤吸收对治疗关节炎的影响更大，因此可用于治疗退行性关节炎和类风湿性关节炎。