公开(公告)号：US06306860B1

公开(公告)日：2001-10-23

申请号：US09674844

申请日：2000-11-07

Applicant: Sung Joon Yoon ,  Sang Wook Lee ,  Hyeong Su Sim ,  Yong Kyun Park ,  Wang Yong Yang ,  Jong Woo Kim ,  Jae Jin Han ,  Je In Yoon ,  Sang Jin Park ,  Hee Jeoung Park ,  Dong Hyuk Sin ,  Hwan Bong Chang

Inventor： Sung Joon Yoon ,  Sang Wook Lee ,  Hyeong Su Sim ,  Yong Kyun Park ,  Wang Yong Yang ,  Jong Woo Kim ,  Jae Jin Han ,  Je In Yoon ,  Sang Jin Park ,  Hee Jeoung Park ,  Dong Hyuk Sin ,  Hwan Bong Chang

IPC: C07D40114

CPC classification number: C07D213/82 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Anti-viral agents of formula (1) have been identified. Their preparation method is described. These 2,5-pyridinedicarboxylic acid derivatives or their pharmaceutically acceptable salts are useful in countering the proliferation of viruses such as hepatitis B virus and human immunodeficiency virus.

Abstract translation: 已经鉴定了式（1）的抗病毒剂。 描述了它们的制备方法。 这些2,5-吡啶二羧酸衍生物或其药学上可接受的盐可用于对抗乙型肝炎病毒和人类免疫缺陷病毒等病毒的增殖。

公开(公告)号：US5922871A

公开(公告)日：1999-07-13

申请号：US956948

申请日：1997-10-23

Applicant: Sung Joon Yoon ,  Yong Ho Chung ,  Sang Wook Lee ,  Hyeong Su Sim ,  Yong Kyun Park ,  Jong Woo Kim ,  Yong Huh ,  Jae In Yoon ,  Sang Jin Park

Inventor： Sung Joon Yoon ,  Yong Ho Chung ,  Sang Wook Lee ,  Hyeong Su Sim ,  Yong Kyun Park ,  Jong Woo Kim ,  Yong Huh ,  Jae In Yoon ,  Sang Jin Park

IPC: C07D213/74 ,  C07D405/12 ,  C07D413/00 ,  A61K31/495 ,  C07D401/00

CPC classification number: C07D213/74 ,  C07D405/12

Abstract: The present invention relates to novel terephthalamide derivatives and in particular to novel terephthalamide derivatives of the following formula 1, its pharmaceutically acceptable salts as antiviral agents having remarkable inhibitory actions against the proliferation of various viruses including HIV and HBV, and preparing method thereof ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same as defined in the detailed description of the present invention.

Abstract translation: 本发明涉及新型对苯二酰胺衍生物，特别涉及下式1的新型对苯二甲酰胺衍生物，其药学上可接受的盐作为抗病毒剂，对各种病毒（包括HIV和HBV）具有显着的抑制作用及其制备方法，其中R1， R2和R3与本发明的详细描述中所定义的相同。