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1.发明公开公开(公告)号：US20230176598A1
公开(公告)日：2023-06-08
申请号：US18162057
申请日：2023-01-31
IPC分类号： G05D23/19 , F26B5/06 , G01K1/14 , G01K1/024 , G01K7/34 , H04W4/70 , G05D22/02 , G05D27/02 , G06Q10/0639
CPC分类号： G05D23/1917 , F26B5/06 , G01K1/14 , G01K1/024 , G01K7/34 , H04W4/70 , G05D22/02 , G05D23/1904 , G05D23/1919 , G05D23/1932 , G05D27/02 , G06Q10/06395 , G01K2215/00
摘要： An arrangement for monitoring an aseptic manufacturing process includes product condition sensors capable of making closely spaced measurements of a product condition such as temperature or humidity. The measurements are made using closely spaced sensors arranged in a linear array on a single probe, which may be used to take measurements at multiple levels within the product. Data from the sensors is transmitted to a data collection point via short range wireless digital communications. The sensors may be used to measure temperature and humidity at a single point. For example, when the sensors are used in pharmaceutical freeze drying, the location of a sublimation front may be calculated for each vial, and the freeze drying process may be controlled using the data.
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2.发明授权公开(公告)号：US11609587B2
公开(公告)日：2023-03-21
申请号：US16805785
申请日：2020-03-01
IPC分类号： G05D23/19 , F26B5/06 , G01K1/14 , G01K1/024 , G01K7/34 , H04W4/70 , G05D22/02 , G05D27/02 , G06Q10/06 , G06Q10/0639
摘要： An arrangement for monitoring an aseptic manufacturing process includes product condition sensors capable of making closely spaced measurements of a product condition such as temperature or humidity. The measurements are made using closely spaced sensors arranged in a linear array on a single probe, which may be used to take measurements at multiple levels within the product. Data from the sensors is transmitted to a data collection point via short range wireless digital communications. The sensors may be used to measure temperature and humidity at a single point. For example, when the sensors are used in pharmaceutical freeze drying, the location of a sublimation front may be calculated for each vial, and the freeze drying process may be controlled using the data.
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公开(公告)号：US11359861B2
公开(公告)日：2022-06-14
申请号：US17043263
申请日：2019-04-09
摘要： In a system and method for controlling a freeze drying process, a diagnostics server (718) is connected for receiving time series data from a freeze drying system (710, 711). The diagnostics server uses a tuned freeze drying system mathematical model to analyze the time series data to predict a system event, and alter the freeze drying process. An analytics server (730) is connected for secure communication with the diagnostics server, and creates and tunes the freeze drying system mathematical model. An equipment provider service and diagnostic cloud (735) may apply learning algorithms to the time series data to enhance diagnostic tools and provide predictive maintenance and diagnostic services to the operator of the first production sites using the diagnostic tools.
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公开(公告)号：US20210190425A1
公开(公告)日：2021-06-24
申请号：US16762596
申请日：2017-11-22
发明人： ARNAB GANGULY , FRANCIS W. DEMARCO , ERNESTO RENZI
摘要： A freeze dryer processes a bulk material including a liquid, and produces a product including the freeze dried material borne on a substrate. The material is introduced in a freezing chamber as a droplet stream that impinges on the substrate. The liquid in the material is frozen after it contacts the substrate. The substrate bearing the material is transferred through a vacuum lock into a vacuum drying chamber where the frozen liquid sublimates under vacuum and applied heat.
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公开(公告)号：US09945611B2
公开(公告)日：2018-04-17
申请号：US14678385
申请日：2015-04-03
发明人： Francis W. DeMarco , Ernesto Renzi , Arnab Ganguly
IPC分类号： F26B5/06
CPC分类号： F26B5/065
摘要： A freeze dryer processes bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen. The resultant powder is freeze dried in a vessel, and the vessel contents is agitated to maintain product contact with heated vessel wall and to prevent agglomeration.
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公开(公告)号：US20240085106A1
公开(公告)日：2024-03-14
申请号：US18273097
申请日：2022-01-20
摘要： A freeze drying vessel having a drying chamber and moveable transfer belts each moved by a driven drum. Each transfer belt includes a transfer surface that transports frozen particles. Each transfer surface is arranged vertically in the chamber and moves in an opposite direction than a lower transfer surface. A removal device is located adjacent each driven drum that removes frozen particles from an end of each transfer surface, respectively, to enable removed frozen particles to flow downward to a lower transfer surface. A heating element is located adjacent each transfer belt to sublimate the frozen particles to form freeze dried product.
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公开(公告)号：US11448463B2
公开(公告)日：2022-09-20
申请号：US17282585
申请日：2019-10-01
发明人： Arnab Ganguly , Francis W. Demarco , Ernesto Renzi
摘要： A freeze drying vessel (302) having a freeze drying chamber (304) that includes sloped horizontal shelves (352) that receive frozen particles (282). Each shelf is sloped relative to a horizontal axis (390) and arranged such that a downward slope between successive shelves alternates between first (392) and second (394) directions. At least one connecting member (374, 376, 378, 380, 382, 384, 386, 386, 388) is attached between pairs of shelves. At least one connecting member is attached to an associated vibration element (396, 398, 400, 402) located outside the drying chamber. Each vibration element vibrates a pair of shelves to cause the frozen particles to advance relative to an associated shelf and drop downward from shelf to shelf wherein the shelves heat the frozen particles to promote sublimation to form freeze dried product (284).
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公开(公告)号：US10465985B2
公开(公告)日：2019-11-05
申请号：US15573718
申请日：2016-05-25
发明人： Arnab Ganguly , Francis W. Demarco , Ernesto Renzi , David Debo
摘要： A freeze dryer processes aseptic bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen to produce a frozen powder. The frozen powder is freeze dried in a vessel by dielectrically heating the frozen powder using electromagnetic radiation such as microwave radiation or infrared radiation, and the frozen powder is continuously agitated using a sterilizable apparatus such as a series of vibrating shelves to maintain even heating and to prevent agglomeration.
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公开(公告)号：US20180274986A1
公开(公告)日：2018-09-27
申请号：US15544592
申请日：2016-01-27
摘要： An arrangement for monitoring a freeze drying process includes product condition sensors for product condition measurement within product vials. The product condition sensors are bimetal junctions deposited on a substrate using an ink jet printing process. The substrate may be a flexible film applied to an interior surface of the product vial, or may be the vial surface itself. The bimetal junction may be printed using a roll-roll inkjet printing process with metallic nanoparticle inks. Multiple closely-spaced bi-metal junctions are provided in each measurement vial. Data from the sensors is transmitted to a data collection point via short range wireless digital communications. The location of a sublimation front may be calculated for each measured vial, and the freeze drying process may be controlled using the data.
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10.发明申请公开(公告)号：US20180011502A1
公开(公告)日：2018-01-11
申请号：US15546023
申请日：2016-01-26
CPC分类号： G05D23/1917 , F26B5/06 , G01K1/024 , G01K1/14 , G01K7/34 , G01K2215/00 , G05D22/02 , G05D23/1904 , G05D23/1919 , G05D23/1932 , G05D27/02 , G06Q10/06395 , H04W4/70
摘要： An arrangement for monitoring an aseptic manufacturing process includes product condition sensors capable of making closely spaced measurements of a product condition such as temperature or humidity. The measurements are made using closely spaced sensors arranged in a linear array on a single probe, which may be used to take measurements at multiple levels within the product. Data from the sensors is transmitted to a data collection point via short range wireless digital communications. The sensors may be used to measure temperature and humidity at a single point. For example, when the sensors are used in pharmaceutical freeze drying, the location of a sublimation front may be calculated for each vial, and the freeze drying process may be controlled using the data.
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