公开(公告)号：US20140127214A1

公开(公告)日：2014-05-08

申请号：US13859054

申请日：2013-04-09

Applicant: Immune Disease Institute, Inc. ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

Inventor： Michael C. Carroll ,  Francis D. Moore, JR. ,  Herbert B. Hechtman

IPC: C07K16/18

CPC classification number: C07K7/08 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/57 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/52

Abstract: The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.

Abstract translation: 本发明提供可用于治疗各种炎性疾病或病症的天然IgM抗体抑制剂。

公开(公告)号：US20130287857A1

公开(公告)日：2013-10-31

申请号：US13844100

申请日：2013-03-15

Applicant: Massachusetts Institute of Technology ,  Immune Disease Institute ,  President and Fellows of Harvard College ,  Partners Healthcare System, Inc.

Inventor： Ulrich H. von Andrian ,  Omid C. Farokhzad ,  Robert S. Langer ,  Tobias Junt ,  Elliott Ashley Moseman ,  Liangfang Zhang ,  Pamela Basto ,  Matteo Iannacone ,  Frank Alexis

IPC: A61K39/12 ,  A61K39/00

CPC classification number: A61K9/14 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K47/6911 ,  A61K47/6937 ,  A61K2039/555 ,  A61K2039/60 ,  Y02A50/464 ,  Y02A50/472

Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at last one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.

公开(公告)号：US20130158101A1

公开(公告)日：2013-06-20

申请号：US13761444

申请日：2013-02-07

Applicant: IMMUNE DISEASE INSTITUTE, INC.

Inventor： Anjana Rao ,  Patrick Hogan ,  Sonia Sharma

IPC: A61K31/713

CPC classification number: A61K31/713 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y306/01

Abstract: Embodiments of the inventions relate to modulating NFAT activity, modulating store-operated Ca2+ entry into a cell and treating and/or preventing hyperactivity or inappropriate immune response by inhibiting the expression or activities of proteins involved in the calcineurin/NFAT axis.

Abstract translation: 本发明的实施方案涉及通过抑制参与钙调神经磷酸酶/ NFAT轴的蛋白质的表达或活性来调节NFAT活性，调节储存操作的Ca 2+进入细胞并治疗和/或预防多动症或不适当的免疫应答。

公开(公告)号：US20130136732A1

公开(公告)日：2013-05-30

申请号：US13747307

申请日：2013-01-22

Applicant: Baxter Healthcare S.A. ,  Baxter International Inc. ,  Immune Disease Institute, Inc.

Inventor： Denisa Wagner ,  Anil Kumar Chauhan ,  Friedrich Scheiflinger ,  Barbara Plaimauer

IPC: C12N9/64

CPC classification number: C12N9/6489 ,  A61K38/17 ,  A61K38/4886

Abstract: This invention relates to a pharmaceutical composition having thrombolytic activity comprising ADAMTS13, and to methods for treating or preventing a disorder associated with the formation and/or the presence of one or more thrombus and to methods of disintegrating one or more thrombus in a patient in need thereof. Furthermore, the invention relates to the use of a pharmaceutically effective amount of ADAMTS13 for the preparation of a pharmaceutical composition for treating or preventing a disorder associated with the formation or the presence of one or more thrombus and for disintegrating one or more thrombus in a patient in need thereof.

Abstract translation: 本发明涉及具有包含ADAMTS13的溶栓活性的药物组合物，以及用于治疗或预防与一种或多种血栓的形成和/或存在相关的病症的方法以及在需要的患者中分解一种或多种血栓的方法 其中。 此外，本发明涉及药物有效量的ADAMTS13用于制备用于治疗或预防与形成或存在一种或多种血栓并且在患者中分解一种或多种血栓有关的病症的药物组合物的用途 需要它。

公开(公告)号：US20130236533A1

公开(公告)日：2013-09-12

申请号：US13844258

申请日：2013-03-15

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  PARTNERS HEALTHCARE SYSTEM, INC. ,  IMMUNE DISEASE INSTITUTE

Inventor： Ulrich H. von Andrian ,  Omid C. Farokhzad ,  Robert S. Langer ,  Tobias Junt ,  Elliott Ashley Moseman ,  Liangfang Zhang ,  Pamela Basto ,  Matteo Iannacone ,  Frank Alexis

IPC: A61K39/39

CPC classification number: A61K9/14 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K47/6911 ,  A61K47/6937 ,  A61K2039/555 ,  A61K2039/60 ,  Y02A50/464 ,  Y02A50/472

Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at last one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.

Abstract translation: 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供了在一些实施方案中能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，其包含至少一种免疫调节剂，并且任选地包含最后一个靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含本发明疫苗纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明疫苗纳米载体及其药物组合物的方法。 本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种本发明的疫苗纳米载体。

公开(公告)号：US20140314865A1

公开(公告)日：2014-10-23

申请号：US13844382

申请日：2013-03-15

Applicant: Massachusetts Institute of Technology ,  Partners Healthcare System, Inc. ,  President and Fellows of Harvard College ,  Immune Disease Institute

Inventor： Ulrich H. von Andrian ,  Omid C. Farokhzad ,  Robert S. Langer ,  Tobias Junt ,  Elliott Ashley Moseman ,  Liangfang Zhang ,  Pamela Basto ,  Matteo Iannacone ,  Frank Alexis

IPC: A61K9/14 ,  A61K39/39

CPC classification number: A61K9/14 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K47/6911 ,  A61K47/6937 ,  A61K2039/555 ,  A61K2039/60 ,  Y02A50/464 ,  Y02A50/472

Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at last one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.

Abstract translation: 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供了在一些实施方案中能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，其包含至少一种免疫调节剂，并且任选地包含最后一个靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含本发明疫苗纳米载体的药物组合物。 本发明提供了设计，制造和使用本发明疫苗纳米载体及其药物组合物的方法。 本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种本发明的疫苗纳米载体。