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公开(公告)号：US20210015949A1
公开(公告)日：2021-01-21
申请号：US16980252
申请日：2019-03-07
发明人： Guillermina FERRO FLORES , Blanca Elí OCAMPO GARCÍA , Myrna Alejandra LUNA GUTIÉRREZ , Clara Leticia SANTOS CUEVAS , Erika Patricia AZORÍN VEGA , Nallely Patricia JIMÉNEZ MANCILLA , Tania HERNÁNDEZ JIMÉNEZ , Flor de María RAMÍREZ DE LA CRUZ
IPC分类号： A61K51/04
摘要： The invention relates to a new lutetium-177 therapeutic radiopharmaceutical as an inhibitor of prostate-specific membran antigen (iPSMA), wherein 1,4,7,10-tetraazacyclododecane-N,N′,N″,N″″-tetraacetic acid (DOTA) bonded to the heterocyclic molecule hydrazinonicotinamide (HYNIC), generates a rigid chemical structure that minimises the number of conformers and intramolecular hydrogen bonds, thereby producing a favourable spatial orientation of the active site (Lys(Nal)-NH—CO—NH-Glu) in the molecule, for biological recognition by the PSMA protein. The new 177Lu-DOTA-HYNIC-iPSMA radiopharmaceutical accumulates, with high affinity in vivo, in tumours that overexpress the PSMA protein, acting as a radiotherapeutic agent. The purpose of the invention is to provide a new specific radiopharmaceutical (molecular target radiopharmaceutical) for the treatment of tumours with PSMA over
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公开(公告)号：US11547767B2
公开(公告)日：2023-01-10
申请号：US17135424
申请日：2020-12-28
发明人： Guillermina Ferro Flores , Blanca Eli Ocampo Garcia , Clara Leticia Santos Cuevas , Myrna Alejandra Luna Gutiérrez , Erika Patricia Azorin Vega , Nallely Patricia Jiménez Mancilla
摘要： The invention relates to a novel radiopharmaceutical that inhibits the prostate-specific membrane antigen (iPSMA), containing hydrazinonicotinamide (HYNIC) as a critical chemical group in increasing in the lipophilicity of the molecule for binding to the hydrophobic sites of the PSMA, combined with the conventional use of HYNIC as a chelating agent for radiometal 99mTc, in which the ethylenediaminetetraacetic acid (EDDA) is used to complete the coordination sphere of the radiometal. The novel radiopharmaceutical 99mTc-EDDA/HYNIC-iPSMA detects, with high affinity and sensitivity in vivo, the overexpressed PSMA protein in prostate cancer cells using SPECT molecular imaging techniques in nuclear medicine. The aim of the invention is to provide a novel specific radiopharmaceutical (radiopharmaceutical for molecular targets) for SPECT, with high sensitivity for the detection of tumours with overexpression of PSMA.
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3.发明申请METHOD AND SYSTEM FOR OBTAINING SWEET GAS, SYNTHETIC GAS AND SULPHUR FROM NATURAL GAS 有权从天然气获得甜味气，合成气和硫磺的方法和系统公开(公告)号：US20150008368A1
公开(公告)日：2015-01-08
申请号：US13935313
申请日：2013-07-03
申请人： CENTRO DE INVESTIGACION EN QUIMICA APLICADA , INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES , CENTRO DE INVESTIGACION CIENTIFICA DE YUCATAN, A. C.
发明人： Yibran Argenis PERERA MERCADO , Luis Alfonso GARCIA CERDA , Griselda CASTRUITA DE LEON , Luis Alberto VILLARREAL CARDENAS , Maria Guadalupe NEIRA VELAZQUEZ , Manuel de Jesus AGUILAR VEGA , Maria Isabel de los Dolores LORIA BASTARRACHEA , Jose Luis SANTIAGO GARCIA , Alejandra Aimee GUTIERREZ MEJIA , Joel Osvaldo PACHECO SOTELO , Marquidia Josseline PACHECO PACHECO , Ricardo VALDIVIA BARRIENTOS , Jose Fidel RAMOS FLORES , Miguel Angel DURAN GARCIA , Miguel Angel HIDALGO PEREZ
CPC分类号： B01D63/00 , B01D53/228 , B01D71/54 , B01J19/088 , B01J2219/00006 , B01J2219/0871 , B01J2219/0875 , B01J2219/0894 , C01B3/04 , C01B17/0495 , C10L3/103 , C10L3/104 , C10L3/105 , Y02E60/364
摘要： A method for obtaining sweet gas, synthetic gas, and sulphur from natural gas. The method includes the steps of removing impurities from the natural gas for obtaining pre-treated natural gas; sweetening the pre-treated natural gas through a separation using a plurality of membranes for obtaining sweet gas and acid gases; ionizing the acid gases to dissociate them into sulphur and synthetic gas with remnants of acid gases; and neutralizing the synthetic gas with remnants of acid gases for generating sweet gas. Likewise, a system is presented on how to implement the method.
摘要翻译： 从天然气中获得甜味气，合成气和硫的方法。 该方法包括从天然气中除去杂质以获得预处理天然气的步骤; 通过使用多个膜分离来预处理天然气以获得甜气体和酸性气体; 将酸性气体离子化，将其分解成硫和合成气体，残留酸性气体; 并用残留的酸性气体中和合成气体产生甜味气体。 同样，介绍了如何实现该方法的系统。
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公开(公告)号：US20240216551A1
公开(公告)日：2024-07-04
申请号：US18288838
申请日：2021-10-14
申请人： Guillermina FERRO-FLORES , Blanca Elí OCAMPO-GARCÍA , INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES
发明人： Guillermina FERRO-FLORES , Blanca Elí OCAMPO-GARCÍA , Myrna Alejandra LUNA-GUTIÉRREZ , Clara Leticia SANTOS-CUEVAS , Nallely Patricia JIMÉNEZ-MANCILLA , Erika Patricia AZORIN-VEGA
IPC分类号： A61K51/04
CPC分类号： A61K51/0455 , A61K51/0497 , A61K2123/00
摘要： This invention relates to new fibroblast activation protein (iFAP) inhibitory radiopharmaceuticals based on the molecule ((R)-1-((6-hydrazinylnicotinoyl)-D-alanyl)pyrrolidin-2-yl)boronic acid (HYNIC-iFAP), where the hydrazine nitrogens of HYNIC act as favorable chemical groups for the interaction of the HYNIC-iFAP molecule with phenylalanine (Phe-350 and Phe-351), glutamic acid (Glu-203 and Glu-204) and with serine (Ser-624) in the active center of fibroblast activation protein (FAP), coupled with the conventional use of HYNIC as a chelating agent for the radiometal 99mTc, where ethylenediamine diacetic acid (EDDA) is used to complete the coordination sphere of the radiometal. The new radiopharmaceutical from 99mTc-EDDA/HYNIC-iFAP (99mTc-HYNIC-iFAP) detects, with high affinity in vivo, FAP expressed in the microenvironment of malignant tumors of epithelial origin using nuclear medicine SPECT molecular imaging techniques. The object of this invention is to provide a new SPECT-specific radiopharmaceutical with high sensitivity for the detection of FAP protein expression in the tumor microenvironment, based on boronPro-type inhibitors (molecular target radiopharmaceutical).
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公开(公告)号：US10918745B2
公开(公告)日：2021-02-16
申请号：US16310744
申请日：2017-06-21
发明人： Guillermina Ferro Flores , Blanca Elí Ocampo García , Clara Leticia Santos Cuevas , Myrna Alejandra Luna Gutiérrez , Erika Patricia Azorín Vega , Nallely Patricia Jiménez Mancilla
摘要： The invention relates to a novel radiopharmaceutical that inhibits the prostate-specific membrane antigen (iPSMA), containing hydrazinonicotinamide (HYNIC) as a critical chemical group in increasing in the lipophilicity of the molecule for binding to the hydrophobic sites of the PSMA, combined with the conventional use of HYNIC as a chelating agent for radiometal 99mTc, in which the ethylenediaminetetraacetic acid (EDDA) is used to complete the coordination sphere of the radiometal. The novel radiopharmaceutical 99mTc-EDDA/HYNIC-iPSMA detects, with high affinity and sensitivity in vivo, the overexpressed PSMA protein in prostate cancer cells using SPECT molecular imaging techniques in nuclear medicine. The aim of the invention is to provide a novel specific radiopharmaceutical (radiopharmaceutical for molecular targets) for SPECT, with high sensitivity for the detection of tumours with overexpression of PSMA.
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公开(公告)号：US12128114B2
公开(公告)日：2024-10-29
申请号：US16980252
申请日：2019-03-07
发明人： Guillermina Ferro Flores , Blanca Elí Ocampo García , Myrna Alejandra Luna Gutiérrez , Clara Leticia Santos Cuevas , Erika Patricia Azorín Vega , Nallely Patricia Jiménez Mancilla , Tania Hernández Jiménez , Flor de María Ramírez De La Cruz
CPC分类号： A61K51/041
摘要： The invention relates to a new lutetium-177 therapeutic radiopharmaceutical as an inhibitor of prostate-specific membrane antigen (iPSMA), wherein 1,4,7,10-tetraazacyclododecane-N,N′,N″,N″″-tetraacetic acid (DOTA) bonded to the heterocyclic molecule hydrazinonicotinamide (HYNIC), generates a rigid chemical structure that minimises the number of conformers and intramolecular hydrogen bonds, thereby producing a favourable spatial orientation of the active site (Lys(Nal)-NH—CO—NH-Glu) in the molecule, for biological recognition by the PSMA protein. The new 177Lu-DOTA-HYNIC-iPSMA radiopharmaceutical accumulates, with high affinity in vivo, in tumours that overexpress the PSMA protein, acting as a radiotherapeutic agent. The purpose of the invention is to provide a new specific radiopharmaceutical (molecular target radiopharmaceutical) for the treatment of tumours with PSMA overexpression.
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公开(公告)号：US20210187132A1
公开(公告)日：2021-06-24
申请号：US17135424
申请日：2020-12-28
发明人： Guillermina FERRO FLORES , Blanca Elí OCAMPO GARCÍA , Clara Leticia SANTOS CUEVAS , Myrna Alejandra LUNA GUTIÉRREZ , Erika Patricia AZORÍN VEGA , Nallely Patricia JIMÉNEZ MANCILLA
摘要： The invention relates to a novel radiopharmaceutical that inhibits the prostate-specific membrane antigen (iPSMA), containing hydrazinonicotinamide (HYNIC) as a critical chemical group in increasing in the lipophilicity of the molecule for binding to the hydrophobic sites of the PSMA, combined with the conventional use of HYNIC as a chelating agent for radiometal 99mTc, in which the ethylenediaminetetraacetic acid (EDDA) is used to complete the coordination sphere of the radiometal. The novel radiopharmaceutical 99mTc-EDDA/HYNIC-iPSMA detects, with high affinity and sensitivity in vivo, the overexpressed PSMA protein in prostate cancer cells using SPECT molecular imaging techniques in nuclear medicine. The aim of the invention is to provide a novel specific radiopharmaceutical (radiopharmaceutical for molecular targets) for SPECT, with high sensitivity for the detection of tumours with overexpression of PSMA.
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8.发明授权Method and system for obtaining sweet gas, synthetic gas and sulphur from natural gas 有权从天然气中获得甜味气，合成气和硫的方法和系统公开(公告)号：US09533260B2
公开(公告)日：2017-01-03
申请号：US13935313
申请日：2013-07-03
申请人： CENTRO DE INVESTIGACION EN QUIMICA APLICADA , CENTRO DE INVESTIGACION CIENTIFICA DE YUCATAN, A. C. , INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES
发明人： Yibran Argenis Perera Mercado , Luis Alfonso Garcia Cerda , Griselda Castruita De Leon , Luis Alberto Villarreal Cardenas , Maria Guadalupe Neira Velazquez , Manuel de Jesus Aguilar Vega , Maria Isabel de los Dolores Loria Bastarrachea , Jose Luis Santiago Garcia , Alejandra Aimee Gutierrez Mejia , Joel Osvaldo Pacheco Sotelo , Marquidia Josseline Pacheco Pacheco , Ricardo Valdivia Barrientos , Jose Fidel Ramos Flores , Miguel Angel Duran Garcia , Miguel Angel Hidalgo Perez
IPC分类号： B01J19/08 , C01B17/04 , C01B3/06 , C07C7/144 , B01D63/00 , B01D53/22 , B01D71/54 , C10L3/10 , C01B3/04
CPC分类号： B01D63/00 , B01D53/228 , B01D71/54 , B01J19/088 , B01J2219/00006 , B01J2219/0871 , B01J2219/0875 , B01J2219/0894 , C01B3/04 , C01B17/0495 , C10L3/103 , C10L3/104 , C10L3/105 , Y02E60/364
摘要： A method for obtaining sweet gas, synthetic gas, and sulphur from natural gas. The method includes the steps of removing impurities from the natural gas for obtaining pre-treated natural gas; sweetening the pre-treated natural gas through a separation using a plurality of membranes for obtaining sweet gas and acid gases; ionizing the acid gases to dissociate them into sulphur and synthetic gas with remnants of acid gases; and neutralizing the synthetic gas with remnants of acid gases for generating sweet gas. Likewise, a system is presented on how to implement the method.
摘要翻译： 从天然气中获得甜味气，合成气和硫的方法。 该方法包括从天然气中除去杂质以获得预处理天然气的步骤; 通过使用多个膜分离来预处理天然气以获得甜气体和酸性气体; 将酸性气体离子化，将其分解成硫和合成气体，残留酸性气体; 并用残留的酸性气体中和合成气体产生甜味气体。 同样，介绍了如何实现该方法的系统。
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