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1.发明申请HETEROCYCLIC COMPOUNDS BASED ON N6-SUBSTITUTED ADENINE, METHODS OF THEIR PREPARATION, THEIR USE FOR PREPARATION OF DRUGS, COSMETIC PREPARATIONS AND GROWTH REGULATORS, PHARMACEUTICAL PREPARATIONS, COSMETIC PREPARATIONS AND GROWTH REGULATORS CONTAINING THESE COMPOUNDS 有权基于N6取代腺嘌呤的杂环化合物，其制备方法，其制备药物，化妆品制剂和生长调节剂，药物制剂，化妆品制剂和含有这些化合物的生长调节剂的使用公开(公告)号：US20080014227A1
公开(公告)日：2008-01-17
申请号：US11779828
申请日：2007-07-18
申请人： Igor Popa , Jan Holub , Rene Lenobel , Stefaan Werbrouck , Karel Dolezal , Miroslav Strnad , Marek Zatloukal , Frank Massino
发明人： Igor Popa , Jan Holub , Rene Lenobel , Stefaan Werbrouck , Karel Dolezal , Miroslav Strnad , Marek Zatloukal , Frank Massino
CPC分类号： A01N43/90 , A61K8/4953 , A61Q19/00 , A61Q19/08
摘要： Novel heterocyclic derivatives based on N6-substituted adenine, having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译： 基于N 6 - 取代腺嘌呤的新型杂环衍生物，具有植物，动物和人细胞的抗癌，有丝分裂，免疫抑制和抗衰老特性及其制备方法。 还包括药物组合物，化妆品制剂和生长调节剂，其含有这些衍生物作为活性化合物，以及这些衍生物在制备药物，化妆品制剂，生物技术方法，化妆品和农业中的用途。
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2.发明申请Substitution derivatives of n6-benzyladenosine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds 有权n6-苄基腺苷的取代衍生物，其制备方法，其用于制备药物，化妆品制剂和生长调节剂，药物制剂，化妆品制剂和含有这些化合物的生长调节剂公开(公告)号：US20060166925A1
公开(公告)日：2006-07-27
申请号：US10540993
申请日：2003-12-29
申请人： Karel Dolezal , Igor Popa , Marek Zatloukal , Rene Lenobel , Dana Hradecka , Borivoj Vojtesek , Stjepan Uldrijan , Petr Mlejnek , Stefaan Werbrouck , Miroslav Strnad
发明人： Karel Dolezal , Igor Popa , Marek Zatloukal , Rene Lenobel , Dana Hradecka , Borivoj Vojtesek , Stjepan Uldrijan , Petr Mlejnek , Stefaan Werbrouck , Miroslav Strnad
IPC分类号： C07H19/16 , A61K31/7076
摘要： The invention concerns novel substitution derivatives of N6-benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N6-benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译： 本发明涉及对植物，动物和人类细胞具有抗癌，有丝分裂，免疫抑制和抗衰老特性的N 6 - 苄基腺苷的新型取代衍生物。 本发明还涉及这些N 6 - 苄基腺苷衍生物的制备方法及其作为药物，化妆品制剂和包含这些衍生物作为活性化合物的生长调节剂的用途，以及这些衍生物用于制备药物组合物的用途 ，在生物技术过程中，在化妆品和农业领域。
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3.发明申请Heterocyclic compound based on n6-substituted adenine, methods, of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds 有权基于n6取代腺嘌呤的杂环化合物，其制备方法，其用于制备药物，化妆品制剂和生长调节剂的用途，药物制剂，化妆品制剂和含有这些化合物的生长调节剂公开(公告)号：US20050043328A1
公开(公告)日：2005-02-24
申请号：US10485091
申请日：2002-08-01
申请人： Karel Dolezal , Igor Popa , Jan Holub , Rene Lenobel , Stefaan Werbrouck , Miroslav Strnad , Marek Zatloukal
发明人： Karel Dolezal , Igor Popa , Jan Holub , Rene Lenobel , Stefaan Werbrouck , Miroslav Strnad , Marek Zatloukal
IPC分类号： C07D473/00 , A01N43/48 , A01N43/90 , A61K8/00 , A61K8/49 , A61K31/52 , A61P3/10 , A61P9/00 , A61P13/12 , A61P17/06 , A61P19/02 , A61P19/06 , A61P25/00 , A61P25/28 , A61P29/00 , A61P33/00 , A61P35/00 , A61P37/06 , A61P43/00 , A61Q19/00 , A61Q19/08 , C07D473/16 , C07D473/34 , C07H19/16 , A61K31/522 , C07D473/10
CPC分类号： A01N43/90 , A61K8/4953 , A61Q19/00 , A61Q19/08
摘要： New heterocyclic derivatives based on N6-substituted adenine, having anticancer, mitotic, imunosuppressive and antisenescent propoerties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译： 基于N 6取代腺嘌呤的新型杂环衍生物，具有抗癌，有丝分裂，免疫抑制和抗衰老的植物，动物和人类细胞的优势及其制备方法。 还包括药物组合物，化妆品制剂和生长调节剂，其含有这些衍生物作为活性化合物，以及这些衍生物在制备药物，化妆品制剂，生物技术方法，化妆品和农业中的用途。
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4.发明授权Heterocyclic compounds based on N6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds 有权基于N6取代腺嘌呤的杂环化合物，其制备方法，其用于制备药物，化妆品制剂和生长调节剂，药物制剂，化妆品制剂和含有这些化合物的生长调节剂公开(公告)号：US08552013B2
公开(公告)日：2013-10-08
申请号：US11779828
申请日：2007-07-18
申请人： Igor Popa , Jan Holub , René Lenobel , Stefaan Werbrouck , Karel Dolezal , Miroslav Strnad , Marek Zatloukal , Frank J. Massino
发明人： Igor Popa , Jan Holub , René Lenobel , Stefaan Werbrouck , Karel Dolezal , Miroslav Strnad , Marek Zatloukal , Frank J. Massino
IPC分类号： A01N43/90 , A01N43/48 , A61K8/00 , A61K31/52 , A61K8/49 , A61P43/00 , A61P17/06 , C07D473/34 , C07D473/00 , A61Q19/00 , A61Q19/08
CPC分类号： A01N43/90 , A61K8/4953 , A61Q19/00 , A61Q19/08
摘要： Novel heterocyclic derivatives based on N6-substituted adenine, having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译： 基于N6取代腺嘌呤的新型杂环衍生物，具有植物，动物和人细胞的抗癌，有丝分裂，免疫抑制和抗衰老特性及其制备方法。 还包括药物组合物，化妆品制剂和生长调节剂，其含有这些衍生物作为活性化合物，以及这些衍生物在制备药物，化妆品制剂，生物技术方法，化妆品和农业中的用途。
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5.发明授权Substitution derivatives of N6-benzyladenosine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds 有权N6-苄基腺苷的取代衍生物，其制备方法，其用于制备药物，化妆品制剂和生长调节剂，药物制剂，化妆品制剂和含有这些化合物的生长调节剂公开(公告)号：US08119614B2
公开(公告)日：2012-02-21
申请号：US10540993
申请日：2003-12-29
申请人： Karel Dolezal , Igor Popa , Marek Zatloukal , René Lenobel , Dana Hradecká , Borivoj Vojtesek , Stjepan Uldrijan , Petr Mlejnek , Stefaan Werbrouck , Miroslav Strnad
发明人： Karel Dolezal , Igor Popa , Marek Zatloukal , René Lenobel , Dana Hradecká , Borivoj Vojtesek , Stjepan Uldrijan , Petr Mlejnek , Stefaan Werbrouck , Miroslav Strnad
IPC分类号： C07H19/167 , C07H19/173 , A01N43/04 , A61K31/70 , A61K8/02
摘要： The invention concerns novel substitution derivatives of N6-benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N6-benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译： 本发明涉及对植物，动物和人类细胞具有抗癌，有丝分裂，免疫抑制和抗衰老特性的N6-苄基腺苷的新型取代衍生物。 本发明还涉及这些N6-苄基腺苷衍生物的制备方法及其作为药物，化妆品制剂和包含这些衍生物作为活性化合物的生物调节剂的用途，以及这些衍生物在制备药物组合物中的用途，在生物技术方法中在化妆品中的用途 在农业。
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6.发明申请Substituted 6-(alkylbenzylamino)purine derivatives for use as cytokinin receptor antagonists and preparations containing these derivatives 审中-公开用作细胞分裂素受体拮抗剂和含有这些衍生物的制剂的6-（烷基苄基氨基）嘌呤衍生物公开(公告)号：US20100240537A1
公开(公告)日：2010-09-23
申请号：US12680762
申请日：2008-10-03
申请人： Lukas Spichal , Igor Popa , Jiri Voller , Karel Dolezal , Miroslav Strnad , Tomas Werner , Thomas Schmulling
发明人： Lukas Spichal , Igor Popa , Jiri Voller , Karel Dolezal , Miroslav Strnad , Tomas Werner , Thomas Schmulling
IPC分类号： A01N43/90 , C07D473/34
CPC分类号： A01N43/90 , C07D473/34
摘要： The invention relates to 6-(alkylbenzylamino)purine derivatives of the general formula I for use as cytokinin receptor antagonists, wherein R1 is selected from the group comprising hydroxyl, amino, nitro, thio and alkyl group, and R2 denotes one to four alkyl groups. The invention also relates to preparations containing these derivatives.
摘要翻译： 本发明涉及用作细胞分裂素受体拮抗剂的通式I的6-（烷基苄基氨基）嘌呤衍生物，其中R1选自羟基，氨基，硝基，硫代和烷基，R2表示一至四个烷基 。 本发明还涉及含有这些衍生物的制剂。
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7.发明授权Heterocyclic compound based on N6-substituted adenine, methods, of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds 有权基于N6-取代腺嘌呤的杂环化合物，其制备方法，其用于制备药物，化妆品制剂和生长调节剂的用途，药物制剂，化妆品制剂和含有这些化合物的生长调节剂公开(公告)号：US07279482B2
公开(公告)日：2007-10-09
申请号：US10485091
申请日：2002-08-01
申请人： Karel Dolezal , Igor Popa , Jan Holub , René Lenobel , Stefaan Werbrouck , Miroslav Strnad , Marek Zatloukal
发明人： Karel Dolezal , Igor Popa , Jan Holub , René Lenobel , Stefaan Werbrouck , Miroslav Strnad , Marek Zatloukal
IPC分类号： C07D473/34 , A61K31/52 , A61P37/06 , A61P35/00 , A01N43/54
CPC分类号： A01N43/90 , A61K8/4953 , A61Q19/00 , A61Q19/08
摘要： Heterocyclic derivatives based on N6-substituted adenine of, e.g.,a formula: wherein R2 is hydrogen, R6 is R6′-X, X is —NH—, and R6′ is substituted phenyl or substituted benzyl. The derivatives possess anticancer, mitotic, imunosuppressive and antisenescent properties for plant, animal and human cells, and methods of their preparation are disclosed. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译： 基于N 6 - 取代腺嘌呤的杂环衍生物，例如下式：其中R2是氢，R6是R6'-X，X是-NH-，R6'是取代的苯基或取代的苄基 。 该衍生物具有植物，动物和人类细胞的抗癌，有丝分裂，抑制和抗衰老特性，并且公开了它们的制备方法。 还包括药物组合物，化妆品制剂和生长调节剂，其含有这些衍生物作为活性化合物，以及这些衍生物在制备药物，化妆品制剂，生物技术方法，化妆品和农业中的用途。
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8.发明授权Substituted 6-(2-hydroxybenzylamino)purine derivatives, their use as medicaments and compositions containing these derivatives 失效取代的6-（2-羟基苄基氨基）嘌呤衍生物，它们用作药物和含有这些衍生物的组合物公开(公告)号：US08492391B2
公开(公告)日：2013-07-23
申请号：US13375343
申请日：2010-06-02
申请人： Marek Zatloukal , Vladimir Krystof , Libor Havlicek , Igor Popa , Karel Dolezal , Miroslav Strnad , Radek Jorda
发明人： Marek Zatloukal , Vladimir Krystof , Libor Havlicek , Igor Popa , Karel Dolezal , Miroslav Strnad , Radek Jorda
IPC分类号： C07D473/16 , A61K31/52
CPC分类号： C07D473/16
摘要： The invention relates to substituted 6-(2-hydroxybenzylamino)purines of general formula I, to their activity as cyclin-dependent kinases 2, 5, 7 and 9 inhibitors and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation or inflammation. The invention further includes pharmaceutical compositions containing the substituted 6-(2-hydroxybenzylamino)purines.
摘要翻译： 本发明涉及通式I的取代的6-（2-羟基苄基氨基）嘌呤，其作为细胞周期蛋白依赖性激酶2,5,7和9抑制剂的活性及其作为药物的用途，特别是用于治疗涉及细胞增殖的疾病 或炎症。 本发明还包括含有取代的6-（2-羟基苄基氨基）嘌呤的药物组合物。
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9.发明申请Substituted 6-(2-hydroxybenzylamino)purine Derivatives, Their Use as Medicaments and Compositions Containing These Derivatives 失效取代的6-（2-羟基苄基氨基）嘌呤衍生物，它们用作含有这些衍生物的药物和组合物公开(公告)号：US20120070512A1
公开(公告)日：2012-03-22
申请号：US13375343
申请日：2010-06-02
申请人： Marek Zatloukal , Vladimir Krystof , Libor Havlicek , Igor Popa , Karel Dolezal , Miroslav Strnad , Radek Jorda
发明人： Marek Zatloukal , Vladimir Krystof , Libor Havlicek , Igor Popa , Karel Dolezal , Miroslav Strnad , Radek Jorda
IPC分类号： A61K33/24 , A61K31/52 , A61P35/00 , A61P11/06 , A61P9/00 , A61P25/16 , A61P29/00 , A61P37/06 , A61P3/10 , A61P19/06 , A61P25/00 , C07D473/16 , A61P25/28
CPC分类号： C07D473/16
摘要： The invention relates to substituted 6-(2-hydroxybenzylamino)purines of general formula I, to their activity as cyclin-dependent kinases 2, 5, 7 and 9 inhibitors and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation or inflammation. The invention further includes pharmaceutical compositions containing the substituted 6-(2-hydroxybenzylamino)purines.
摘要翻译： 本发明涉及通式I的取代的6-（2-羟基苄基氨基）嘌呤，其作为细胞周期蛋白依赖性激酶2,5,7和9抑制剂的活性及其作为药物的用途，特别是用于治疗涉及细胞增殖的疾病 或炎症。 本发明还包括含有取代的6-（2-羟基苄基氨基）嘌呤的药物组合物。
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