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1.发明授权Heterocyclic compounds based on N6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds 有权基于N6取代腺嘌呤的杂环化合物，其制备方法，其用于制备药物，化妆品制剂和生长调节剂，药物制剂，化妆品制剂和含有这些化合物的生长调节剂公开(公告)号：US08552013B2
公开(公告)日：2013-10-08
申请号：US11779828
申请日：2007-07-18
申请人： Igor Popa , Jan Holub , René Lenobel , Stefaan Werbrouck , Karel Dolezal , Miroslav Strnad , Marek Zatloukal , Frank J. Massino
发明人： Igor Popa , Jan Holub , René Lenobel , Stefaan Werbrouck , Karel Dolezal , Miroslav Strnad , Marek Zatloukal , Frank J. Massino
IPC分类号： A01N43/90 , A01N43/48 , A61K8/00 , A61K31/52 , A61K8/49 , A61P43/00 , A61P17/06 , C07D473/34 , C07D473/00 , A61Q19/00 , A61Q19/08
CPC分类号： A01N43/90 , A61K8/4953 , A61Q19/00 , A61Q19/08
摘要： Novel heterocyclic derivatives based on N6-substituted adenine, having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.
摘要翻译： 基于N6取代腺嘌呤的新型杂环衍生物，具有植物，动物和人细胞的抗癌，有丝分裂，免疫抑制和抗衰老特性及其制备方法。 还包括药物组合物，化妆品制剂和生长调节剂，其含有这些衍生物作为活性化合物，以及这些衍生物在制备药物，化妆品制剂，生物技术方法，化妆品和农业中的用途。
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2.发明申请公开(公告)号：US20110224238A1
公开(公告)日：2011-09-15
申请号：US13116636
申请日：2011-05-26
申请人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Ludek Frolich , Karel Dolezal , Miroslav Strnad , Frank J. Massino
发明人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Ludek Frolich , Karel Dolezal , Miroslav Strnad , Frank J. Massino
CPC分类号： A61K8/49 , A61K8/4953 , A61K9/0014 , A61K31/52 , A61Q19/08
摘要： The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives.
摘要翻译： 本发明提供了用于抵抗老化对体外和体内哺乳动物细胞，特别是人皮肤细胞和人皮肤的不利影响以及哺乳动物过度增殖和相关皮肤疾病的治疗的方法和组合物，通过施用含有6,9-二取代 嘌呤衍生物
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3.发明申请公开(公告)号：US20100234401A1
公开(公告)日：2010-09-16
申请号：US12786027
申请日：2010-05-24
申请人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Ludek Frohlich , Karel Dolezal , Miroslav Strnad , Frank J. Massino
发明人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Ludek Frohlich , Karel Dolezal , Miroslav Strnad , Frank J. Massino
CPC分类号： A61K8/49 , A61K8/4953 , A61K9/0014 , A61K31/52 , A61Q19/08
摘要： The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives.
摘要翻译： 本发明提供了用于抵抗老化对体外和体内哺乳动物细胞，特别是人皮肤细胞和人皮肤的不利影响以及哺乳动物过度增殖和相关皮肤疾病的治疗的方法和组合物，通过施用含有6,9-二取代 嘌呤衍生物
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4.发明申请6,9-Disubstituted Purine Derivatives and Their Use as Cosmetics and Cosmetic Compositions 有权6,9-二取代的嘌呤衍生物及其作为化妆品和化妆品组合物的用途公开(公告)号：US20090170879A1
公开(公告)日：2009-07-02
申请号：US11966559
申请日：2007-12-28
申请人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Jiri Voller , Karel Dolezal , Miroslav Strnad , Frank J. Massino
发明人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Jiri Voller , Karel Dolezal , Miroslav Strnad , Frank J. Massino
IPC分类号： A61K31/52 , C07D473/00 , A61P17/00
CPC分类号： C07D473/00
摘要： Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.
摘要翻译： 提供了某些6,9-二取代的嘌呤衍生物及其药学上可接受的盐。 这些6,9-二取代的嘌呤衍生物及其药学上可接受的盐可用于治疗哺乳动物细胞，特别是人类皮肤细胞的组合物，以改善老化的不利影响，治疗皮肤疾病状态，治疗由于或相关的 与炎症等。
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5.发明申请公开(公告)号：US20080009508A1
公开(公告)日：2008-01-10
申请号：US11774652
申请日：2007-07-09
申请人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Ludek Frohlich , Karel Dolezal , Miroslav Strnad , Frank J. Massino
发明人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Ludek Frohlich , Karel Dolezal , Miroslav Strnad , Frank J. Massino
CPC分类号： A61K8/49 , A61K8/4953 , A61K9/0014 , A61K31/52 , A61Q19/08
摘要： The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives.
摘要翻译： 本发明提供了用于抵抗老化对体外和体内哺乳动物细胞，特别是人皮肤细胞和人皮肤的不利影响以及哺乳动物过度增殖和相关皮肤疾病的治疗的方法和组合物，通过施用含有6,9-二取代 嘌呤衍生物
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6.发明授权6,9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions 有权6,9-二取代嘌呤衍生物及其作为化妆品和化妆品组合物的用途公开(公告)号：US07960397B2
公开(公告)日：2011-06-14
申请号：US11966559
申请日：2007-12-28
申请人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Jiri Voller , Karel Dolezal , Miroslav Strnad , Frank J. Massino
发明人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Jiri Voller , Karel Dolezal , Miroslav Strnad , Frank J. Massino
IPC分类号： A61P17/16 , A61K31/52 , C07D473/34 , A61P37/06
CPC分类号： C07D473/00
摘要： Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the following general formula are provided wherein R6 and R9 are as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for application to mammalian cells, and especially human skin cells, in order to improve the cosmetic appearance of the mammalian cells, especially human skin.
摘要翻译： 提供了某些6,9-二取代的嘌呤衍生物及其药学上可接受的下列通式的盐，其中R6和R9如说明书中所定义。 这些6,9-二取代的嘌呤衍生物及其药学上可接受的盐可用于用于哺乳动物细胞，特别是人皮肤细胞的组合物中，以改善哺乳动物细胞，特别是人类皮肤的美容外观。
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7.发明授权6, 9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions 有权6,9-二取代嘌呤衍生物及其作为化妆品和化妆品组合物的用途公开(公告)号：US08575182B2
公开(公告)日：2013-11-05
申请号：US13116725
申请日：2011-05-26
申请人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Jiri Voller , Karel Dolezal , Miroslav Strnad , Frank J. Massino
发明人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Jiri Voller , Karel Dolezal , Miroslav Strnad , Frank J. Massino
IPC分类号： A61K31/52 , A61P17/16 , C07D473/34 , A61P37/06
CPC分类号： C07D473/00
摘要： Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the general formula are provided wherein R6 and R9 are as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.
摘要翻译： 提供某些6,9-二取代的嘌呤衍生物及其通式的药学上可接受的盐，其中R6和R9如说明书中所定义。 这些6,9-二取代的嘌呤衍生物及其药学上可接受的盐可用于治疗哺乳动物细胞，特别是人类皮肤细胞的组合物，以改善老化的不利影响，治疗皮肤疾病状态，治疗由于或相关的 与炎症等。
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8.发明申请6, 9-Disubstituted Purine Derivatives and Their Use as Cosmetics and Cosmetic Compositions 有权6,9-二取代嘌呤衍生物及其作为化妆品和化妆品组合物的用途公开(公告)号：US20110230503A1
公开(公告)日：2011-09-22
申请号：US13116725
申请日：2011-05-26
申请人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Jiri Voller , Karel Dolezal , Miroslav Strnad , Frank J. Massino
发明人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Jiri Voller , Karel Dolezal , Miroslav Strnad , Frank J. Massino
CPC分类号： C07D473/00
摘要： Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.
摘要翻译： 提供了某些6,9-二取代的嘌呤衍生物及其药学上可接受的盐。 这些6,9-二取代的嘌呤衍生物及其药学上可接受的盐可用于治疗哺乳动物细胞，特别是人类皮肤细胞的组合物，以改善老化的不利影响，治疗皮肤疾病状态，治疗由于或相关的 与炎症等。
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9.发明申请公开(公告)号：US20130072505A1
公开(公告)日：2013-03-21
申请号：US13630673
申请日：2012-09-28
申请人： Lucie Szucova , Marek Zatioukai , Lukas Spichal , Ludek Frohich , Karel Dolezal , Miroslav Stmad , Frank J. Massino
发明人： Lucie Szucova , Marek Zatioukai , Lukas Spichal , Ludek Frohich , Karel Dolezal , Miroslav Stmad , Frank J. Massino
CPC分类号： A61K8/49 , A61K8/4953 , A61K9/0014 , A61K31/52 , A61Q19/08
摘要： The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives.
摘要翻译： 本发明提供了用于抵抗老化对体外和体内哺乳动物细胞，特别是人皮肤细胞和人皮肤的不利影响以及哺乳动物过度增殖和相关皮肤疾病的治疗的方法和组合物，通过施用含有6,9-二取代 嘌呤衍生物
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