公开(公告)号：US20110313320A1

公开(公告)日：2011-12-22

申请号：US13003986

申请日：2009-08-18

申请人： Ira H. Gewolb ,  Frank L. Vice

发明人： Ira H. Gewolb ,  Frank L. Vice

IPC分类号： A61B7/00

CPC分类号： A61B7/008 ,  A61B5/11 ,  A61B5/4211 ,  A61B5/6823 ,  A61B5/7257 ,  A61B5/726 ,  A61B2562/0204 ,  A61B2562/0219

摘要： The present invention provides compositions and methods useful in the diagnosis and management of Gastroesophageal Reflux. Specifically, the inventions provide a device and methods of using the device for accurately, quantitatively, and non-invasively diagnosing Gastroesophageal reflux disease (GERD) in both patients at risk for GERD and patients demonstrating reflux-like symptoms. In particular, the inventions relate to detecting and analyzing upward esophageal movements in patients, such as human infants, children, and adults.

摘要翻译： 本发明提供了用于诊断和治疗胃食管反流的组合物和方法。 具体地说，本发明提供了一种使用该装置的装置和方法，用于准确，定量和非侵入性地诊断患有GERD风险的患者和表现出类似反流症状的患者的胃食管反流病（GERD）。 特别地，本发明涉及检测和分析患者（例如人类婴儿，儿童和成人）中的向上食管运动。

公开(公告)号：US5981590A

公开(公告)日：1999-11-09

申请号：US819624

申请日：1997-03-17

申请人： Pinaki Panigrahi ,  Karoly Horvath ,  Ira H. Gewolb

发明人： Pinaki Panigrahi ,  Karoly Horvath ,  Ira H. Gewolb

IPC分类号： A61K31/198 ,  A61K31/195

CPC分类号： A61K31/198

摘要： A method of preventing necrotizing tissue injury in the gastrointestinal tract comprising orally administering glutamine is disclosed. Glutamine protects tissues along the gastrointestinal tract by blocking translocation of bacterial agents such as gram (-) bacteria, other infectious agents, toxins, chemicals and injurious substances. The intraluminal/apical presence of the glutamine optimizes mucosal defense and increases nutrient absorption. Enteral glutamine is useful in treating neonatal necrotizing enterocolitis for reducing inflammation caused by bacterial translocation and injury. Oral glutamine is also useful in treating gastrointestinal dysfunctions. When glutamine is orally administered, it coats gastrointestinal mucosa thereby treating infectious and/or inflammatory conditions of the gastrointestinal tract. It is useful in treating pathologic conditions with lowered transepithelial electrical resistance (TEER) by acting as a curative agent.

摘要翻译： 公开了一种预防胃肠道坏死组织损伤的方法，其包括口服施用谷氨酰胺。 谷氨酰胺通过阻止细菌剂如克（ - ）细菌，其他感染因子，毒素，化学物质和有害物质的移位来保护沿着胃肠道的组织。 谷氨酰胺的管腔内/顶端存在优化粘膜防御并增加营养吸收。 肠内谷氨酰胺可用于治疗新生儿坏死性小肠结肠炎，以减少由细菌易位和损伤引起的炎症。 口服谷氨酰胺也可用于治疗胃肠功能障碍。 当口服施用谷氨酰胺时，其涂覆胃肠粘膜，从而治疗胃肠道的感染性和/或炎性病症。 通过作为治疗剂治疗具有降低的跨上皮电阻（TEER）的病理状况是有用的。

公开(公告)号：US08568336B2

公开(公告)日：2013-10-29

申请号：US13003986

申请日：2009-08-18

申请人： Ira H. Gewolb ,  Frank L. Vice

发明人： Ira H. Gewolb ,  Frank L. Vice

IPC分类号： A61B6/00

CPC分类号： A61B7/008 ,  A61B5/11 ,  A61B5/4211 ,  A61B5/6823 ,  A61B5/7257 ,  A61B5/726 ,  A61B2562/0204 ,  A61B2562/0219

摘要： The present invention provides compositions and methods useful in the diagnosis and management of Gastroesophageal Reflux. Specifically, the inventions provide a device and methods of using the device for accurately, quantitatively, and non-invasively diagnosing Gastroesophageal reflux disease (GERD) in both patients at risk for GERD and patients demonstrating reflux-like symptoms. In particular, the inventions relate to detecting and analyzing upward esophageal movements in patients, such as human infants, children, and adults.

摘要翻译： 本发明提供了用于诊断和治疗胃食管反流的组合物和方法。 具体地说，本发明提供了一种使用该装置的装置和方法，用于准确，定量和非侵入性地诊断患有GERD风险的患者和表现出类似反流症状的患者的胃食管反流病（GERD）。 特别地，本发明涉及检测和分析患者（例如人类婴儿，儿童和成人）中的向上食管运动。

公开(公告)号：US6132710A

公开(公告)日：2000-10-17

申请号：US818995

申请日：1997-03-17

申请人： Pinaki Panigrahi ,  Ira H. Gewolb ,  J. Glenn Morris, Jr.

发明人： Pinaki Panigrahi ,  Ira H. Gewolb ,  J. Glenn Morris, Jr.

IPC分类号： A61K35/74 ,  A61K35/747 ,  A01N63/00 ,  C12N1/00 ,  C12N1/20

CPC分类号： C12R1/225 ,  A61K35/747 ,  C12R1/25 ,  Y10S435/853 ,  Y10S435/857

摘要： Gastrointestinal tissue injury and infections are treated by orally administering Lactobacilli strains. The Lactobacilli strains prevent neonatal necrotizing enterocolitis tissue injury and necrotizing enterocolitis in preterm infants. Preterm infants, full-term infants, children and adults as well as animals may be given the Lactobacilli strains. The strains are Lactobacillus salivarius strain ATCC 202196 and Lactobacillus plantarum strain ATCC 202195. Further, the strains may be given individually or as a combination of the two strains. In addition, the strains are useful in treating diarrhea. The Lactobacilli strains normalize and balance bacterial milieu in the gastro-intestinal tract. The Lactobacilli strains may be in lyophilized capsule form. The capsule may be an enteric coated slow-release microcapsule. The Lactobacilli strains may also be administered by means of a naso-gastric tube, especially for preterm infants.

摘要翻译： 胃肠道组织损伤和感染通过口服施用乳杆菌菌株进行治疗。 乳杆菌菌株预防早产儿新生儿坏死性小肠结肠炎组织损伤和坏死性小肠结肠炎。 早产儿，足月婴儿，儿童和成年人以及动物可能会获得乳杆菌菌株。 菌株是唾液乳杆菌菌株ATCC 202196和植物乳杆菌菌株ATCC 202195.此外，菌株可以单独给予或作为两种菌株的组合给予。 此外，该菌株可用于治疗腹泻。 乳杆菌菌株使胃肠道中的细菌环境正常化和平衡。 乳杆菌菌株可以是冻干胶囊形式。 胶囊可以是肠溶包衣缓释微胶囊。 乳杆菌菌株也可以通过鼻胃管，特别是早产儿来施用。