公开(公告)号：US20060263877A1

公开(公告)日：2006-11-23

申请号：US11415072

申请日：2006-05-02

申请人： Axel Ullrich ,  Mikhail Gishizky ,  Irmingard Sures

发明人： Axel Ullrich ,  Mikhail Gishizky ,  Irmingard Sures

IPC分类号： C12N5/06 ,  C07K16/40

CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K16/40 ,  C07K2319/00 ,  C12N2799/027 ,  C12P21/02

摘要： The present invention relates to novel cytoplasmic tyrosine kinases isolated from megakaryocytes (megakaryocyte kinases or MKKs) which are involved in cellular signal transduction pathways and to the use of these novel proteins in the diagnosis and treatment of disease. The present invention further relates to specific megakaryocyte kinases, designated MKK1, MKK2 and MKK3, and their use as diagnostic and therapeutic agents.

摘要翻译： 本发明涉及从涉及细胞信号转导途径的巨核细胞（巨核细胞激酶或MKK）分离的新型细胞质酪氨酸激酶以及这些新型蛋白在诊断和治疗疾病中的用途。 本发明还涉及称为MKK1，MKK2和MKK3的特异性巨核细胞激酶及其作为诊断和治疗剂的用途。

公开(公告)号：US06326469B1

公开(公告)日：2001-12-04

申请号：US08426509

申请日：1995-04-21

申请人： Axel Ullrich ,  Mikhail Gishizky ,  Irmingard Sures

发明人： Axel Ullrich ,  Mikhail Gishizky ,  Irmingard Sures

IPC分类号： C07K1700

CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/027

摘要： The present invention relates to novel cytoplasmic tyrosine kinases isolated from megakaryocytes (megakaryocyte kinases or MKKs) which are involved in cellular signal transduction pathways and to the use of these novel proteins in the diagnosis and treatment of disease. The present invention further relates to specific megakaryocyte kinases, designated MKK1, MKK2 and MKK3, and their use as diagnostic and therapeutic agents.

摘要翻译： 本发明涉及从涉及细胞信号转导途径的巨核细胞（巨核细胞激酶或MKK）分离的新型细胞质酪氨酸激酶以及这些新型蛋白在诊断和治疗疾病中的用途。 本发明还涉及称为MKK1，MKK2和MKK3的特异性巨核细胞激酶及其作为诊断和治疗剂的用途。

公开(公告)号：US07037677B2

公开(公告)日：2006-05-02

申请号：US09977260

申请日：2001-10-16

申请人： Axel Ullrich ,  Mikhail Gishizky ,  Irmingard Sures

发明人： Axel Ullrich ,  Mikhail Gishizky ,  Irmingard Sures

IPC分类号： C12P21/06 ,  C12P21/04 ,  C12N15/00 ,  C07H21/04

CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K16/40 ,  C07K2319/00 ,  C12N2799/027 ,  C12P21/02

摘要： The present invention relates to novel cytoplasmic tyrosine kinases isolated from megakaryoctyes (megakaryocyte kinases or MKKs) which are involved in cellular signal transduction pathways and to the use of these novel proteins in the diagnosis and treatment of disease. The present invention further relates to specific megakaryocyte kinases, designated MKK1, MKK2, and MKK3, and their use as diagnostic and therapeutic agents.

摘要翻译： 本发明涉及从参与细胞信号转导途径的巨核细胞（megakaryocyte kinases or MKKs）分离的新型细胞质酪氨酸激酶以及这些新型蛋白在诊断和治疗疾病中的应用。 本发明还涉及称为MKK1，MKK2和MKK3的特异性巨核细胞激酶及其作为诊断和治疗剂的用途。

公开(公告)号：US06908984B2

公开(公告)日：2005-06-21

申请号：US09977261

申请日：2001-10-16

申请人： Axel Ullrich ,  Mikhail Gishizky ,  Irmingard Sures

发明人： Axel Ullrich ,  Mikhail Gishizky ,  Irmingard Sures

IPC分类号： A61K38/00 ,  C12N9/12 ,  C12P21/04 ,  C07K14/00 ,  A61K39/00

CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/027

摘要： The present invention relates to novel cytoplasmic tyrosine kinases isolated from megakaryocytes (megakaryocyte kinases or MKKs) which are involved in cellular signal transduction pathways and to the use of these novel proteins in the diagnosis and treatment of disease. The present invention further relates to specific megakaryocyte kinases, designated MKK1, MKK2, and MKK3, and their use as diagnostic and therapeutic agents.

摘要翻译： 本发明涉及从涉及细胞信号转导途径的巨核细胞（巨核细胞激酶或MKK）分离的新型细胞质酪氨酸激酶以及这些新型蛋白在诊断和治疗疾病中的用途。 本发明还涉及称为MKK1，MKK2和MKK3的特异性巨核细胞激酶及其作为诊断和治疗剂的用途。