公开(公告)号：US20120136258A1

公开(公告)日：2012-05-31

申请号：US13357939

申请日：2012-01-25

申请人： Charles P. Lin ,  Clemens Alt ,  Israel Veilleux ,  Daniel Cote

发明人： Charles P. Lin ,  Clemens Alt ,  Israel Veilleux ,  Daniel Cote

IPC分类号： A61B6/00

CPC分类号： A61B3/1241 ,  A61B3/1233

摘要： The present invention provides methods and devices for performing flow cytometry. In one embodiment, blood circulating through one or more retinal blood vessels of a subject is illuminated in-vivo so as to excite a plurality of fluorescent-labeled cells contained in the blood. The fluorescence radiation emitted by the excited cells is then detected and analyzed to count the cells from which fluorescence is detected.

摘要翻译： 本发明提供了用于进行流式细胞术的方法和装置。 在一个实施方案中，循环通过受试者的一个或多个视网膜血管的血液被体内照射，以激发包含在血液中的多个荧光标记的细胞。 然后检测并分析由激发的细胞发射的荧光辐射以计数检测到荧光的细胞。

公开(公告)号：US20110060232A1

公开(公告)日：2011-03-10

申请号：US12114413

申请日：2008-05-02

申请人： Charles P. Lin ,  Clemens Alt ,  Israel Veilleux ,  Daniel Cote

发明人： Charles P. Lin ,  Clemens Alt ,  Israel Veilleux ,  Daniel Cote

IPC分类号： A61B5/026 ,  A61K51/00

CPC分类号： A61B3/1241 ,  A61B3/1233

摘要： The present invention provides methods and devices for performing flow cytometry. In one embodiment, blood circulating through one or more retinal blood vessels of a subject is illuminated in-vivo so as to excite a plurality of fluorescent-labeled cells contained in the blood. The fluorescence radiation emitted by the excited cells is then detected and analyzed to count the cells from which fluorescence is detected.

摘要翻译： 本发明提供了用于进行流式细胞术的方法和装置。 在一个实施方案中，循环通过受试者的一个或多个视网膜血管的血液被体内照射，以激发包含在血液中的多个荧光标记的细胞。 然后检测并分析由激发的细胞发射的荧光辐射以计数检测到荧光的细胞。

公开(公告)号：US08284483B2

公开(公告)日：2012-10-09

申请号：US13147232

申请日：2010-02-03

申请人： Emmanuel Jean-Marc Beaurepaire ,  Israel Veilleux ,  Nicolas Olivier ,  Delphine Malvina Daniele Marie Debarre ,  Jean-Louis Martin

发明人： Emmanuel Jean-Marc Beaurepaire ,  Israel Veilleux ,  Nicolas Olivier ,  Delphine Malvina Daniele Marie Debarre ,  Jean-Louis Martin

IPC分类号： H01J3/14 ,  G01B9/00 ,  G01B11/00 ,  G01Q60/00

CPC分类号： G02B21/002 ,  G02B21/0048

摘要： A method for acquiring signals in laser scanning microscopy, includes the steps of: moving a focused optical excitation beam relative to an object to be measured so that the focus point of the beam follows a predetermined path in the space of the object; and acquiring optical measurement signals along the path according to at least one acquisition parameter; characterized in that the path of the excitation beam is determined so as to substantially minimize the variations of the optical properties of at least one portion of the environments crossed by the excitation beam between consecutive acquisitions, and in that at least one acquisition parameter among the acquisition parameters is modulated during the movement of the excitation beam. A device for implementing the method is also described.

摘要翻译： 一种用于在激光扫描显微镜中获取信号的方法，包括以下步骤：使聚焦的光学激发光束相对于被测量物体移动，使得光束的聚焦点遵循物体空间中的预定路径; 以及根据至少一个获取参数沿着所述路径获取光学测量信号; 其特征在于，激励光束的路径被确定为基本上最小化在连续采集之间由激励光束交叉的至少一部分环境的光学特性的变化，并且在采集中的至少一个采集参数 参数在激发光束的移动期间被调制。 还描述了用于实现该方法的设备。

公开(公告)号：US20160287211A1

公开(公告)日：2016-10-06

申请号：US15085380

申请日：2016-03-30

申请人： Ralph S. DaCosta ,  Brian C. Wilson ,  Israel Veilleux ,  Jin Ho Chang ,  Jeeun Kang ,  Yangmo Yoo ,  Tai-Kyong Song

发明人： Ralph S. DaCosta ,  Brian C. Wilson ,  Israel Veilleux ,  Jin Ho Chang ,  Jeeun Kang ,  Yangmo Yoo ,  Tai-Kyong Song

IPC分类号： A61B8/00 ,  A61B8/08 ,  A61B8/14

CPC分类号： A61B8/4416 ,  A61B5/0035 ,  A61B5/0071 ,  A61B5/0095 ,  A61B5/7425 ,  A61B8/13 ,  A61B8/14 ,  A61B8/145 ,  A61B8/4405 ,  A61B8/4444 ,  A61B8/4472 ,  A61B8/48 ,  A61B8/5261 ,  G06T7/0012

摘要： Various embodiments are described herein for a method, apparatus and system for performing multi-modal imaging using a common imaging probe having various modes of operation including a fluorescent (FL) imaging mode and at least one of an ultrasound (US) imaging mode, a photoacoustic (PA) imaging mode and a combined US/PA imaging mode. Molecular/functional information may be obtained from FL and PA imaging and anatomical information may be obtained from ultrasound (US) imaging. The system may be implemented to provide for images from each modality in real time as well as provide for co-registration of these images. Experimental results demonstrate that combining the imaging modalities does not significantly compromise the performance of each of the separate US, PA, and FL imaging techniques, while enabling multi-modality registration.

摘要翻译： 在这里描述了用于使用具有各种操作模式的共同成像探头进行多模态成像的方法，装置和系统，包括荧光（FL）成像模式和超声（US）成像模式， 光声（PA）成像模式和US / PA成像模式组合。 可以从FL和PA成像获得分子/功能信息，并且可以从超声（US）成像获得解剖信息。 可以实施该系统以实时地提供来自每个模态的图像，以及提供这些图像的共同配准。 实验结果表明，组合成像模式并不会显着损害每个单独的美国，美国和加拿大成像技术的性能，同时实现多模式注册。