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公开(公告)号：US09018580B2
公开(公告)日：2015-04-28
申请号：US13496949
申请日：2010-09-15
CPC分类号： G01N33/6848 , H01J49/0031 , H01J49/42 , H01J49/427
摘要： A method for detecting at least one target molecule in a sample by mass spectrometry, comprising ionizing the molecules of the sample and then conducting the following steps (i) and (ii) n times, n being equal to 0, 1, 2, 3 or 4: (i) at least one ion obtained in the preceding step is selected, according to the target molecule, in a mass analyzer, and (ii) the ion thus selected is fragmented in a fragmentation cell; trapping at least two different sampled ions, when n is zero, or when n is other than zero, in a mass analyzer, the at least two ions thus trapped having a mass-to-charge ratio m/z characteristic of the target molecule; ejecting the trapped ions from the mass analyzer; and detecting the ejected ions ejected by means of a detection device. The method is characterized in that the characteristic ions are ejected simultaneously and detected simultaneously.
摘要翻译： 一种用于通过质谱法检测样品中的至少一种靶分子的方法，包括使样品的分子电离，然后进行以下步骤（i）和（ii）n次，n等于0,1,2,3 或4：（i）根据靶分子在质量分析器中选择前述步骤中获得的至少一种离子，和（ii）所选择的离子在碎裂单元中碎裂; 捕获至少两种不同的采样离子，当n为零时，或当n不为零时，在质量分析器中，至少两个离子因此被捕获，其具有靶分子的质荷比m / z特性; 从质量分析器中排出被捕获的离子; 并且检测通过检测装置喷射的喷射离子。 该方法的特征在于同时喷射特征离子并同时检测。
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公开(公告)号：US20120205535A1
公开(公告)日：2012-08-16
申请号：US13496949
申请日：2010-09-15
IPC分类号： H01J49/26
CPC分类号： G01N33/6848 , H01J49/0031 , H01J49/42 , H01J49/427
摘要： A method for detecting at least one target molecule in a sample by mass spectrometry, comprising ionizing the molecules of the sample and then conducting the following steps (i) and (ii) n times, n being equal to 0, 1, 2, 3 or 4: (i) at least one ion obtained in the preceding step is selected, according to the target molecule, in a mass analyser, and (ii) the ion thus selected is fragmented in a fragmentation cell; trapping at least two different sampled ions, when n is zero, or when n is other than zero, in a mass analyser, the at least two ions thus trapped having a mass-to-charge ratio m/z characteristic of the target molecule; ejecting the trapped ions from the mass analyser; and detecting the ejected ions ejected by means of a detection device. The method is characterized in that the characteristic ions are ejected simultaneously and detected simultaneously.
摘要翻译： 一种用于通过质谱法检测样品中的至少一种靶分子的方法，包括使样品的分子电离，然后进行以下步骤（i）和（ii）n次，n等于0,1,2,3 或4：（i）根据靶分子在质量分析器中选择前述步骤中获得的至少一种离子，和（ii）所选择的离子在碎裂单元中碎裂; 捕获至少两种不同的采样离子，当n为零时，或当n不为零时，在质量分析器中，至少两个离子因此被捕获，其具有靶分子的质荷比m / z特性; 从质量分析器中排出被捕获的离子; 并且检测通过检测装置喷射的喷射离子。 该方法的特征在于同时喷射特征离子并同时检测。
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