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1.发明申请GENE THERAPY FOR AMYOTROPHIC LATERAL SCLEROSIS AND OTHER SPINAL CORD DISORDERS 有权脊柱侧凸性脊柱炎及其他脊髓损伤的基因治疗公开(公告)号：US20100267812A1
公开(公告)日：2010-10-21
申请号：US12328267
申请日：2008-12-04
CPC分类号： A61K38/30 , A61K48/00 , A61K48/005 , A61K48/0075 , C12N2750/14143 , C12N2799/025
摘要： This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain.
摘要翻译： 本公开提供了用于治疗影响受试者的运动功能和控制的疾病或损伤的方法和组合物。 一方面，本发明通过将包含转基因的重组神经营养病毒载体给予脑，将转基因产物递送至受试者的脊髓。 病毒载体将转基因递送到易受病毒感染并表达编码的重组病毒基因产物的脑区域。 还提供了通过将含有转基因的重组神经营养病毒载体给予受试者的脑，将转基因产物递送至受试者的脊髓的组合物。
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公开(公告)号：US20100173979A1
公开(公告)日：2010-07-08
申请号：US12631336
申请日：2009-12-04
申请人： James DODGE , Seng Cheng
发明人： James DODGE , Seng Cheng
IPC分类号： A61K31/7088
CPC分类号： A61K48/0075 , A61K38/47 , C12N15/86 , C12N2750/14143 , C12Y302/01045
摘要： This disclosure provides methods and compositions for treating lysosomal storage diseases in a subject. In one aspect of the invention, a transgene product is delivered to a subject by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain. The transgene product may be any that is deficient in a lysosomal storage disease.
摘要翻译： 本公开提供了用于治疗受试者中溶酶体贮积病的方法和组合物。 在本发明的一个方面，通过将包含转基因的重组神经营养病毒载体给予脑，将转基因产物递送至受试者。 病毒载体将转基因递送到易受病毒感染并表达编码的重组病毒基因产物的脑区域。 还提供了通过将含有转基因的重组神经营养病毒载体给予受试者的脑，将转基因产物递送给受试者的组合物。 转基因产物可以是溶酶体贮积病中缺乏的任何一种。
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公开(公告)号：US20090105141A1
公开(公告)日：2009-04-23
申请号：US12175870
申请日：2008-07-18
申请人： James Dodge , Ronald K. Scheule
发明人： James Dodge , Ronald K. Scheule
CPC分类号： A61K38/30
摘要： Amyotrophic Lateral Sclerosis can be successfully treated using intraventricular delivery of a neurotrophic growth factor, IGF-1. The administration can be performed slowly to achieve maximum effect. Effects are seen on both sides of the blood-brain barrier, making this a delivery means for Amyotrophic Lateral Sclerosis which affects both brain and skeletal muscle.
摘要翻译： 肌营养不良性侧索硬化可以使用神经营养生长因子IGF-1的脑室内输送成功治疗。 可以缓慢执行给药以达到最大效果。 在血脑屏障的两侧看到效果，这是影响脑和骨骼肌的肌萎缩性侧索硬化的递送手段。
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公开(公告)号：US20060058601A1
公开(公告)日：2006-03-16
申请号：US10915762
申请日：2004-08-11
申请人： Chad Smith , Kyle Johnson , Timothy Behlmer , James Dodge
发明人： Chad Smith , Kyle Johnson , Timothy Behlmer , James Dodge
IPC分类号： A61B5/05
CPC分类号： A61B6/0457 , Y10S5/943
摘要： A system and method for translating a patient table is described. The described patient table includes a linearly translatable portion, a drive screw assembly, a power transmission assembly, and a drive train. The translatable portion is configured to be positioned in a plurality of selectable positions between a fully inserted position and a fully extracted position. The drive screw assembly includes a drive nut and a screw member. The drive nut is fixedly coupled to the translatable portion of the patient table and threadily engaged to the screw member. The screw member is drivingly coupled to the power transmission assembly. The drive train is configured to drive the translatable portion of the patient table at a predetermined insertion force in the insertion direction, and a predetermined extraction force in the extraction direction. The predetermined extraction force is greater than the predetermined insertion force.
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公开(公告)号：US20130058545A1
公开(公告)日：2013-03-07
申请号：US13223946
申请日：2011-09-01
申请人： PHIL E. PEARSON, JR. , SCOTT SLAVIC , JAMES DODGE
发明人： PHIL E. PEARSON, JR. , SCOTT SLAVIC , JAMES DODGE
IPC分类号： G06K9/00
CPC分类号： G06K9/00221 , A61B6/032 , A61B6/037 , A61B6/0492 , A61B6/4417 , A61B6/46 , A61B6/468 , A61B6/547 , G06K9/3208 , G06T7/73 , G06T2207/10072
摘要： A method for determining a subject's orientation includes receiving, at an imaging system, an input that indicates an orientation of a subject being imaged, automatically determining the orientation of the subject using a feature recognition system, comparing the received input to the automatically determined orientation, and generating an image, the image including orientation indicia based on the comparison. An object orientation recognition system and an imaging system are also described herein.
摘要翻译： 一种用于确定被摄体的方位的方法包括在成像系统处接收指示被成像对象的取向的输入，使用特征识别系统自动确定对象的方位，将接收到的输入与自动确定的方向进行比较， 以及生成图像，所述图像包括基于所述比较的取向标记。 本文还描述了对象方向识别系统和成像系统。
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6.发明授权公开(公告)号：US08265989B2
公开(公告)日：2012-09-11
申请号：US12435874
申请日：2009-05-05
申请人： James Dodge , John Donmyer , Frank J. Slavik
发明人： James Dodge , John Donmyer , Frank J. Slavik
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0202 , G06Q30/02
摘要： Example systems, methods, processes, and apparatus for determining expected base sales for a product include obtaining sales data for a product sold at a point of sale location. The sales data can be organized in a time series according to a predetermined time period. The method further includes identifying a promotional event for at least one of the product and the point of sale location and excluding sales data corresponding to the promotional event. The remaining sales data is processed using a smoothed moving average model involving a plurality of passes through the remaining sales data. Expected base data for the product is generated based on the smoothed moving average model and output to a user.
摘要翻译： 用于确定产品的预期基础销售的示例系统，方法，过程和装置包括获取在销售点位置销售的产品的销售数据。 销售数据可以根据预定时间段以时间序列组织。 该方法还包括识别产品和销售点位置中的至少一个的促销事件，并且排除与促销事件相对应的销售数据。 使用平滑的移动平均模型处理剩余的销售数据，该模型涉及通过剩余销售数据的多次通过。 基于平滑的移动平均模型并向用户输出产生产品的预期基本数据。
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公开(公告)号：US20090123451A1
公开(公告)日：2009-05-14
申请号：US12187896
申请日：2008-08-07
CPC分类号： A61K31/00 , A61K9/0024
摘要： Neurological diseases, including lysosomal storage diseases, can be successfully treated using intraventricular delivery of the therapeutic agents to bypass the blood-brain barrier. Similarly, diagnostic agents and anesthetic agents can be delivered to the brain in this manner. The administration can be performed slowly to achieve maximum effect. Such administration permits greater penetration of distal portions of the brain.
摘要翻译： 可以使用治疗剂的脑室内递送绕过血脑屏障来成功地治疗包括溶酶体贮积病的神经疾病。 类似地，诊断剂和麻醉剂可以以这种方式递送到大脑。 可以缓慢执行给药以达到最大效果。 这样的施用允许脑的远端部分更大的穿透。
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公开(公告)号：US10744210B2
公开(公告)日：2020-08-18
申请号：US11934148
申请日：2007-11-02
IPC分类号： A61K48/00 , C12N15/864 , C07K14/475
摘要： This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention provides a method to deliver a transgene to a subject's spinal cord by administering a recombinant neurotropic viral vector containing the transgene. The viral vector delivers the transgene to a region of the deep cerebellar nuclei region of the brain. Also provided are compositions and methods to deliver a transgene to a subject's spinal cord by administering a recombinant neurotropic viral vector containing the transgene to the motor cortex region of the subject's brain.
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9.发明授权Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders 有权用于肌萎缩性侧索硬化症和其他脊髓障碍的基因治疗公开(公告)号：US09034836B2
公开(公告)日：2015-05-19
申请号：US12328267
申请日：2008-12-04
CPC分类号： A61K38/30 , A61K48/00 , A61K48/005 , A61K48/0075 , C12N2750/14143 , C12N2799/025
摘要： This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain.
摘要翻译： 本公开提供了用于治疗影响受试者的运动功能和控制的疾病或损伤的方法和组合物。 一方面，本发明通过将包含转基因的重组神经营养病毒载体给予脑，将转基因产物递送至受试者的脊髓。 病毒载体将转基因递送到易受病毒感染并表达编码的重组病毒基因产物的脑区域。 还提供了通过将含有转基因的重组神经营养病毒载体给予受试者的脑，将转基因产物递送至受试者的脊髓的组合物。
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公开(公告)号：US08796236B2
公开(公告)日：2014-08-05
申请号：US12631336
申请日：2009-12-04
申请人： James Dodge , Seng Cheng
发明人： James Dodge , Seng Cheng
CPC分类号： A61K48/0075 , A61K38/47 , C12N15/86 , C12N2750/14143 , C12Y302/01045
摘要： This disclosure provides methods and compositions for treating lysosomal storage diseases in a subject. In one aspect of the invention, a transgene product is delivered to a subject by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain. The transgene product may be any that is deficient in a lysosomal storage disease.
摘要翻译： 本公开提供了用于治疗受试者中溶酶体贮积病的方法和组合物。 在本发明的一个方面，通过将含有转基因的重组神经营养病毒载体给予脑，将转基因产物递送至受试者。 病毒载体将转基因递送到易受病毒感染并表达编码的重组病毒基因产物的脑区域。 还提供了通过将含有转基因的重组神经营养病毒载体给予受试者的脑，将转基因产物递送给受试者的组合物。 转基因产物可以是溶酶体贮积病中缺乏的任何一种。
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