Compositions and Methods for the Production of Alpha-Herpesviruses
    8.
    发明申请
    Compositions and Methods for the Production of Alpha-Herpesviruses 有权
    疱疹病毒生产的组成和方法

    公开(公告)号:US20110201087A1

    公开(公告)日:2011-08-18

    申请号:US13057788

    申请日:2009-08-11

    Abstract: The present invention relates to virus growth media that improve the yield of alpha-herpesviruses (e.g., HSV-2) grown in cell cultures. The growth media of the invention include two additives, a disaccharide and a lipid mixture, that can be added to serum-free or serum-enriched growth media to improve the efficiency of virus production. The invention further provides methods of producing alpha-herpesviruses (e.g., HSV-2) in such growth media.

    Abstract translation: 本发明涉及提高细胞培养物中生长的α-疱疹病毒(例如HSV-2)产量的病毒生长培养基。 本发明的生长培养基包括可添加到无血清或富含血清的生长培养基中以提高病毒生产效率的两种添加剂,二糖和脂质混合物。 本发明还提供了在这种生长培养基中产生α-疱疹病毒(例如,HSV-2)的方法。

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