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公开(公告)号：US20110200638A1
公开(公告)日：2011-08-18
申请号：US13081549
申请日：2011-04-07
申请人： Arthur Keith Turner , Judith Greenwood , Jonathan Clive Stephens , Juliet Claire Beavis , Michael James Darsley
发明人： Arthur Keith Turner , Judith Greenwood , Jonathan Clive Stephens , Juliet Claire Beavis , Michael James Darsley
IPC分类号： A61K39/108 , A61P31/04
CPC分类号： C12N15/70 , A61K39/00 , A61K39/0258 , A61K2039/521 , A61K2039/522 , A61K2039/53 , C07K14/245 , Y02A50/474
摘要： A bacterial cell which expresses three or more coli surface (CS) antigens and methods of making such a cell. The cell is useful in making vaccines against diarrhea.
摘要翻译： 表达三个或更多个大肠杆菌表面（CS）抗原的细菌细胞和制备这种细胞的方法。 该细胞可用于制造针对腹泻的疫苗。
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公开(公告)号：US20110189225A1
公开(公告)日：2011-08-04
申请号：US13073999
申请日：2011-03-28
申请人： ARTHUR KEITH TURNER , JUDITH GREENWOOD , JONATHAN CLIVE STEPHENS , JULIET CLAIRE BEAVIS , MICHAEL JAMES DARSLEY
发明人： ARTHUR KEITH TURNER , JUDITH GREENWOOD , JONATHAN CLIVE STEPHENS , JULIET CLAIRE BEAVIS , MICHAEL JAMES DARSLEY
IPC分类号： A61K39/108 , A61K39/02 , A61P37/04
CPC分类号： C12N15/70 , A61K39/00 , A61K39/0258 , A61K2039/521 , A61K2039/522 , A61K2039/53 , C07K14/245 , Y02A50/474
摘要： The invention provides strains of bacteria, especially enterotoxigenic E. coli, attenuated by mutations in the genes encoding enterotoxins (LT, ST, EAST1) and optionally further attenuated by deletion of additional chromosomal genes. In addition the invention provides strains of attenuated bacteria expressing immunogenic but non-toxic variants of one or more of these enterotoxins. These bacteria are useful as a vaccine against diarrhoeal disease.
摘要翻译： 本发明提供了通过在编码肠毒素（LT，ST，EAST1）的基因中的突变而减毒的细菌，特别是肠致毒性大肠杆菌菌株，并且任选地通过缺失其它染色体基因进一步减弱。 此外，本发明提供表达一种或多种这些肠毒素的免疫原性但无毒变体的减毒细菌菌株。 这些细菌可用作抗腹泻疾病的疫苗。
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公开(公告)号：US08318148B2
公开(公告)日：2012-11-27
申请号：US13073999
申请日：2011-03-28
申请人： Arthur Keith Turner , Judith Greenwood , Jonathan Clive Stephens , Juliet Claire Beavis , Michael James Darsley
发明人： Arthur Keith Turner , Judith Greenwood , Jonathan Clive Stephens , Juliet Claire Beavis , Michael James Darsley
IPC分类号： A61K39/02 , A61K39/108 , A61K48/00 , A01N63/00 , A01N65/00
CPC分类号： C12N15/70 , A61K39/00 , A61K39/0258 , A61K2039/521 , A61K2039/522 , A61K2039/53 , C07K14/245 , Y02A50/474
摘要： The invention provides strains of bacteria, especially enterotoxigenic E. coli, attenuated by mutations in the genes encoding enterotoxins (LT, ST, EAST1) and optionally further attenuated by deletion of additional chromosomal genes. In addition the invention provides strains of attenuated bacteria expressing immunogenic but non-toxic variants of one or more of these enterotoxins. These bacteria are useful as a vaccine against diarrhoeal disease.
摘要翻译： 本发明提供了通过在编码肠毒素（LT，ST，EAST1）的基因中的突变而减毒的细菌，特别是肠致毒性大肠杆菌菌株，并且任选地通过缺失其它染色体基因进一步减弱。 此外，本发明提供表达一种或多种这些肠毒素的免疫原性但无毒变体的减毒细菌菌株。 这些细菌可用作抗腹泻疾病的疫苗。
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公开(公告)号：US07951361B2
公开(公告)日：2011-05-31
申请号：US10489242
申请日：2002-09-11
申请人： Arthur Keith Turner , Judith Greenwood , Jonathan Clive Stephens , Juliet Claire Beavis , Michael James Darsley
发明人： Arthur Keith Turner , Judith Greenwood , Jonathan Clive Stephens , Juliet Claire Beavis , Michael James Darsley
IPC分类号： A61K39/02 , A61K39/108 , A61K48/00 , A01N63/00 , A01N65/00
CPC分类号： C12N15/70 , A61K39/00 , A61K39/0258 , A61K2039/521 , A61K2039/522 , A61K2039/53 , C07K14/245 , Y02A50/474
摘要： A bacterial cell which expresses three or more coli surface (CS) antigens and methods of making such a cell. The cell is useful in making vaccines against diarrhea.
摘要翻译： 表达三个或更多个大肠杆菌表面（CS）抗原的细菌细胞和制备这种细胞的方法。 该细胞可用于制造针对腹泻的疫苗。
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公开(公告)号：US07943122B2
公开(公告)日：2011-05-17
申请号：US10489273
申请日：2002-09-11
申请人： Arthur Keith Turner , Judith Greenwood , Jonathan Clive Stephens , Juliet Claire Beavis , Michael James Darsley
发明人： Arthur Keith Turner , Judith Greenwood , Jonathan Clive Stephens , Juliet Claire Beavis , Michael James Darsley
IPC分类号： A61K39/02 , A61K39/108 , A61K48/00 , A01N63/00 , A01N65/00
CPC分类号： C12N15/70 , A61K39/00 , A61K39/0258 , A61K2039/521 , A61K2039/522 , A61K2039/53 , C07K14/245 , Y02A50/474
摘要： The invention provides strains of bacteria, especially enterotoxigenic E. coli, attenuated by mutations in the genes encoding enterotoxins (LT, ST, EAST1) and optionally further attenuated by deletion of additional chromosomal genes. In addition the invention provides strains of attenuated bacteria expressing immunogenic but non-toxic variants of one or more of these enterotoxins. These bacteria are useful as a vaccine against diarrhoeal disease.
摘要翻译： 本发明提供了通过在编码肠毒素（LT，ST，EAST1）的基因中的突变而减毒的细菌，特别是肠致毒性大肠杆菌菌株，并且任选地通过缺失其它染色体基因进一步减弱。 此外，本发明提供表达一种或多种这些肠毒素的免疫原性但无毒变体的减毒细菌菌株。 这些细菌可用作抗腹泻疾病的疫苗。
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6.发明申请Epitopes or mimotopes derived from the C-epsilon-3 or C-epsilon-4 domains of IgE, antagonists thereof, and their therapeutic uses 审中-公开衍生自IgE的C-ε-3或C-ε-4结构域的表位或模拟表位，其拮抗剂及其治疗用途公开(公告)号：US20050214285A1
公开(公告)日：2005-09-29
申请号：US11005794
申请日：2004-12-07
申请人： Michael Dyson , Martin Friede , Judith Greenwood , Ellen Hewitt , Alan Lamont , Sean Mason , Roger Randall , William Turnell , Marcelle Van Mechelen , Carlotta y de Bassols
发明人： Michael Dyson , Martin Friede , Judith Greenwood , Ellen Hewitt , Alan Lamont , Sean Mason , Roger Randall , William Turnell , Marcelle Van Mechelen , Carlotta y de Bassols
IPC分类号： A61K39/00 , A61K39/395 , C07K16/42 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6875 , A61K39/0008 , A61K2039/505 , A61K2039/6056 , C07K16/4291 , G01N2800/24
摘要： The present invention relates to the provision of novel medicaments for the treatment, prevention or amelioration of allergic disease. In particular, the novel medicaments are isolated peptides incorporating epitopes or mimotopes of surface exposed regions of the Cε2 domain of IgE. The inventors have found that these novel regions may be the target for both passive and active immunoprophylaxis or immunotherapy. The invention further relates to methods for production of the medicaments, pharmaceutical compositions containing them and their use in medicine. Also forming an aspect of the present invention are ligands, especially monoclonal antibodies, which are capable of binding the surface exposed IgE regions of the present invention, and their use in medicine as passive immunotherapy or in immunoprophylaxis.
摘要翻译： 本发明涉及提供用于治疗，预防或改善过敏性疾病的新型药物。 特别地，新型药物是包含IgE的Cepsilon2结构域的表面暴露区域的表位或模拟表位的分离肽。 发明人已经发现，这些新的区域可能是被动和主动免疫预防或免疫治疗的目标。 本发明还涉及制备药物的方法，含有它们的药物组合物及其在药物中的用途。 还形成本发明的一个方面是能够结合本发明的表面暴露的IgE区域的配体，特别是单克隆抗体，以及它们在医学中作为被动免疫治疗或免疫预防的用途。
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公开(公告)号：US20050054075A1
公开(公告)日：2005-03-10
申请号：US10489273
申请日：2002-09-11
IPC分类号： A61K39/00 , A61K39/02 , A61K39/108 , C07K14/245 , C12N15/70 , C12N1/00
CPC分类号： C12N15/70 , A61K39/00 , A61K39/0258 , A61K2039/521 , A61K2039/522 , A61K2039/53 , C07K14/245 , Y02A50/474
摘要： The invention provides strains of bacteria, especially enterotoxigenic E. coli, attenuated by mutations in the genes encoding enterotoxins (LT, ST, EAST1) and optionally further attenuated by deletion of additional chromosomal genes. In addition the invention provides strains of attenuated bacteria expressing immunogenic but non-toxic variants of one or more of these enterotoxins. These bacteria are useful as a vaccine against diarrhoeal disease.
摘要翻译： 本发明提供了通过在编码肠毒素（LT，ST，EAST1）的基因中的突变而减毒的细菌，特别是肠致毒性大肠杆菌菌株，并且任选地通过缺失其它染色体基因进一步减弱。 此外，本发明提供表达一种或多种这些肠毒素的免疫原性但无毒变体的减毒细菌菌株。 这些细菌可用作抗腹泻疾病的疫苗。
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