公开(公告)号：US20160091485A1

公开(公告)日：2016-03-31

申请号：US14785594

申请日：2014-04-11

Applicant: Ho Man CHAN ,  Veronica GIBAJA ,  Kristy HAAS ,  Jacob JAFFE ,  Mariela JASKELIOFF ,  Frank STEGMEIER ,  Wei QI ,  THE BROAD INSTITUTE, INC.

Inventor： Ho Man CHAN ,  Veronica GIBAJA ,  Kristy HAAS ,  Jacob JAFFE ,  Mariela JASKELIOFF ,  Frank Peter STEGMEIER ,  Wei QI

IPC: G01N33/50

CPC classification number: G01N33/5011 ,  G01N33/57426 ,  G01N33/57484 ,  G01N2560/00 ,  G01N2800/52

Abstract: The invention provides methods of detecting an EZH2 mutation and associated epigenetic markers in a cancer cell, methods cancer diagnosis and methods of screening for EZH2 inhibitors.

Abstract translation: 本发明提供检测癌细胞中EZH2突变和相关表观遗传标记的方法，方法癌症诊断和EZH2抑制剂筛选方法。

公开(公告)号：US20150354006A1

公开(公告)日：2015-12-10

申请号：US14434063

申请日：2013-10-15

Applicant: Ho Man CHAN ,  Nathan P. ENGLUND ,  Levi GARRAWAY ,  Min HU ,  Jacob JAFFE ,  Gregory KRYUKOV ,  Jun LIU ,  Xianghui LIU ,  Rob MCDONALD ,  Frank Peter STEGMEIER ,  Zhaofu WANG ,  Yan WANG ,  Haiping WU ,  Feng YAN

Inventor： Ho Man Chan ,  Nathan P. Englund ,  Levi Garraway ,  Min Hu ,  Jacob Jaffe ,  Gregory Kryukov ,  Jun Liu ,  Xianghui Liu ,  Rob McDonald ,  Frank Peter Stegmeier ,  Zhaofu Wang ,  Yan Wang ,  Haiping Wu ,  Feng Yan

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/156 ,  G01N33/5011 ,  G01N33/57426 ,  G01N2333/91017 ,  G01N2440/12 ,  G01N2500/04 ,  G01N2500/10

Abstract: The invention provides methods of detecting a NSD2 mutation in a cancer cell, methods cancer diagnosis and methods of screening for NSD2 inhibitors.

Abstract translation: 本发明提供检测癌细胞NSD2突变的方法，方法癌症诊断和筛选NSD2抑制剂的方法。