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1.发明授权Ion population control in a mass spectrometer having mass-selective transfer optics 有权具有质量选择性传输光学的质谱仪中的离子群体控制公开(公告)号：US08552365B2
公开(公告)日：2013-10-08
申请号：US12777088
申请日：2010-05-10
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/065
摘要： Methods for operating a mass spectrometer having at least one component having mass-dependent transmission, comprising: injecting a first sample of ions having a first mass range into an ion accumulator for a first injection time under first operating conditions suitable for optimizing transmission of ions of the first range; acquiring a full-scan mass spectrum of the first sample of ions; selecting ion species having a second mass range different than the first range; calculating a second injection time, the second injection time suitable for injecting a population of the selected ion species into the ion accumulator under second operating conditions suitable for optimizing transmission of ions of the second range; injecting a second sample of ions having the selected ion species into the ion accumulator for the second injection time under the second operating conditions; and acquiring a mass spectrum of ions derived from the selected ion species.
摘要翻译： 用于操作具有至少一种具有质量依赖透射率的组分的质谱仪的方法包括：在适于优化离子的透射的第一操作条件下，将具有第一质量范围的离子的第一样品注入离子蓄积器中用于第一注入时间 第一范围; 获取第一离子样品的全扫描质谱; 选择具有不同于所述第一范围的第二质量范围的离子物质; 计算第二注射时间，所述第二注射时间适合于在适于优化所述第二范围的离子的透射的第二操作条件下将所选择的离子物质的群体注入到所述离子蓄积器中; 在第二操作条件下将具有所选择的离子种类的离子的第二样品注入到离子蓄积器中用于第二注入时间; 并获取从所选择的离子种类衍生的离子的质谱。
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公开(公告)号：US20130175441A1
公开(公告)日：2013-07-11
申请号：US13347754
申请日：2012-01-11
IPC分类号： H01J49/36
CPC分类号： H01J49/065 , H01J49/066
摘要： An ion guide that transports ions from an ion source at generally a high-pressure level to a mass analyzer at generally a low-pressure level has a plurality of identical electrodes fabricated with protruding elements that forming an ion tunnel or an ion funnel, when the electrodes are assembled around a common longitudinal axis. The protruding elements allow the generation of the radio frequency field necessary to radially confine ions. Each electrode may be machined from a solid block of conductive material, such as metal. The disclosed arrangement greatly simplifies the manufacturing process, reducing cost, and improving robustness and reliability of the ion guide itself.
摘要翻译： 将离子通常以高压水平传输到质量分析器的离子导向器通常在低压水平下具有多个相同的电极，该电极用形成离子通道或离子漏斗的突出元件制成， 电极围绕共同的纵向轴线组装。 突出元件允许产生径向限制离子所需的射频场。 每个电极可以由诸如金属的导电材料的固体块来加工。 所公开的装置大大简化了制造过程，降低了成本，提高了离子导向器本身的鲁棒性和可靠性。
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公开(公告)号：US08779353B2
公开(公告)日：2014-07-15
申请号：US13347754
申请日：2012-01-11
CPC分类号： H01J49/065 , H01J49/066
摘要： An ion guide that transports ions from an ion source at generally a high-pressure level to a mass analyzer at generally a low-pressure level has a plurality of identical electrodes fabricated with protruding elements that forming an ion tunnel or an ion funnel, when the electrodes are assembled around a common longitudinal axis. The protruding elements allow the generation of the radio frequency field necessary to radially confine ions. Each electrode may be machined from a solid block of conductive material, such as metal. The disclosed arrangement greatly simplifies the manufacturing process, reducing cost, and improving robustness and reliability of the ion guide itself.
摘要翻译： 将离子通常以高压水平传输到质量分析器的离子导向器通常在低压水平下具有多个相同的电极，该电极用形成离子通道或离子漏斗的突出元件制成， 电极围绕共同的纵向轴线组装。 突出元件允许产生径向限制离子所需的射频场。 每个电极可以由诸如金属的导电材料的固体块来加工。 所公开的装置大大简化了制造过程，降低了成本，提高了离子导向器本身的鲁棒性和可靠性。
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公开(公告)号：US08058611B2
公开(公告)日：2011-11-15
申请号：US12565598
申请日：2009-09-23
IPC分类号： H01J49/26
CPC分类号： H01J49/0445
摘要： A system for preventing backflow as part of an ion source arrangement is introduced. Such a system incorporates a novel continuous flow guide within a source, such as an API ion source. In the spray direction, the cross-sectional area that defines the first portion of the internal volume initially decreases in a convergent-like manner and thereafter increases in a divergent-like manner towards the exit opening of the source housing. Such a flow guide has been designed as an integral part of an ion source housing to provide for an optimal unidirectional flow past a sampling orifice of a mass spectrometer inlet. Accordingly, the novel design of the present invention prevents recirculation and thus minimizes carryover, chemical noise, and source turbulence and as an added benefit, enables a user to easily clean such a system during maintenance.
摘要翻译： 引入了用于防止作为离子源装置的一部分的回流的系统。 这样的系统在源内包含新颖的连续流动引导件，例如API离子源。 在喷射方向上，限定内部容积的第一部分的横截面面积首先以收敛方式减小，然后以发散方式朝向源壳体的出口开口增加。 这种流动引导件已被设计为离子源壳体的组成部分，以提供通过质谱仪入口的采样孔的最佳单向流动。 因此，本发明的新颖设计防止再循环，从而使携带，化学噪声和源湍流最小化，并且作为附加的益处，使得用户能够在维护期间容易地清洁这样的系统。
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公开(公告)号：US20110068263A1
公开(公告)日：2011-03-24
申请号：US12565598
申请日：2009-09-23
IPC分类号： H01J49/26
CPC分类号： H01J49/0445
摘要： A system for preventing backflow as part of an ion source arrangement is introduced. Such a system incorporates a novel continuous flow guide within a source, such as an API ion source. In the spray direction, the cross-sectional area that defines the first portion of the internal volume initially decreases in a convergent-like manner and thereafter increases in a divergent-like manner towards the exit opening of the source housing. Such a flow guide has been designed as an integral part of an ion source housing to provide for an optimal unidirectional flow past a sampling orifice of a mass spectrometer inlet. Accordingly, the novel design of the present invention prevents recirculation and thus minimizes carryover, chemical noise, and source turbulence and as an added benefit, enables a user to easily clean such a system during maintenance.
摘要翻译： 引入了用于防止作为离子源装置的一部分的回流的系统。 这样的系统在源内包含新颖的连续流动引导件，例如API离子源。 在喷射方向上，限定内部容积的第一部分的横截面面积首先以收敛方式减小，然后以发散方式朝向源壳体的出口开口增加。 这种流动引导件已被设计为离子源壳体的组成部分，以提供通过质谱仪入口的采样孔的最佳单向流动。 因此，本发明的新颖设计防止再循环，从而使携带，化学噪声和源湍流最小化，并且作为附加的益处，使得用户能够在维护期间容易地清洁这样的系统。
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6.发明申请Ion Population Control in a Mass Spectrometer Having Mass-Selective Transfer Optics 有权具有质量选择性转移光学质谱仪的离子人口控制公开(公告)号：US20100282957A1
公开(公告)日：2010-11-11
申请号：US12777088
申请日：2010-05-10
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/065
摘要： Methods for operating a mass spectrometer having at least one component having mass-dependent transmission, comprising: injecting a first sample of ions having a first mass range into an ion accumulator for a first injection time under first operating conditions suitable for optimizing transmission of ions of the first range; acquiring a full-scan mass spectrum of the first sample of ions; selecting ion species having a second mass range different than the first range; calculating a second injection time, the second injection time suitable for injecting a population of the selected ion species into the ion accumulator under second operating conditions suitable for optimizing transmission of ions of the second range; injecting a second sample of ions having the selected ion species into the ion accumulator for the second injection time under the second operating conditions; and acquiring a mass spectrum of ions derived from the selected ion species.
摘要翻译： 用于操作具有至少一种具有质量依赖透射率的组分的质谱仪的方法包括：在适于优化离子的透射的第一操作条件下，将具有第一质量范围的离子的第一样品注入离子蓄积器中用于第一注入时间 第一范围; 获取第一离子样品的全扫描质谱; 选择具有不同于所述第一范围的第二质量范围的离子物质; 计算第二注射时间，所述第二注射时间适合于在适于优化所述第二范围的离子的透射的第二操作条件下将所选择的离子物质的群体注入到所述离子蓄积器中; 在第二操作条件下将具有所选择的离子种类的离子的第二样品注入到离子蓄积器中用于第二注入时间; 并获取从所选择的离子种类衍生的离子的质谱。
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7.发明授权公开(公告)号：US07915580B2
公开(公告)日：2011-03-29
申请号：US12252013
申请日：2008-10-15
申请人： Maurizio A. Splendore , Eloy R. Wouters , Michael W. Senko , Paul R. Atherton , Jean Jacques Dunyach , Christopher Mullen
发明人： Maurizio A. Splendore , Eloy R. Wouters , Michael W. Senko , Paul R. Atherton , Jean Jacques Dunyach , Christopher Mullen
IPC分类号： H01J49/06
CPC分类号： H01J49/0404 , H01J49/066
摘要： A device for improved transportation and focusing of ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from one or more electro-dynamic or electrostatic focusing lenses that is/are coupled to the first electrode of a stacked ring ion guide (SRIG) to which oscillatory (e.g., radio-frequency) voltages are applied. Such configurations as disclosed herein, minimizes deleterious field effects and/or repositioning problems of desired ion transfer instruments that utilize such stacked ring ion guides by generally configuring the outlet end of the ion transfer device to a desired position within the electro-dynamic or electro-static focusing lens(es).
摘要翻译： 用于改善离子在质谱仪的低真空或大气压力区域中的运输和聚焦的装置由一个或多个电动或静电聚焦透镜构成，所述电动或静电聚焦透镜被耦合到堆叠环离子导向件的第一电极 （SRIG），施加振荡（例如，射频）电压。 通过将离子转移装置的出口端大致配置到电动态或电动式离子转移装置中的期望位置，使这种堆叠的环形离子引导件的所需离子传递装置的有害场效应和/或重新定位问题最小化， 静态聚焦透镜。
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8.发明申请公开(公告)号：US20100090104A1
公开(公告)日：2010-04-15
申请号：US12252013
申请日：2008-10-15
申请人： Maurizio A. Splendore , Eloy R. Wouters , Michael W. Senko , Paul R. Atherton , Jean Jacques Dunyach , Christopher Mullen
发明人： Maurizio A. Splendore , Eloy R. Wouters , Michael W. Senko , Paul R. Atherton , Jean Jacques Dunyach , Christopher Mullen
IPC分类号： B01D59/46
CPC分类号： H01J49/0404 , H01J49/066
摘要： A device for improved transportation and focusing of ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from one or more electro-dynamic or electrostatic focusing lenses that is/are coupled to the first electrode of a stacked ring ion guide (SRIG) to which oscillatory (e.g., radio-frequency) voltages are applied. Such configurations as disclosed herein, minimizes deleterious field effects and/or repositioning problems of desired ion transfer instruments that utilize such stacked ring ion guides by generally configuring the outlet end of the ion transfer device to a desired position within the electro-dynamic or electro-static focusing lens(es).
摘要翻译： 用于改善离子在质谱仪的低真空或大气压力区域中的运输和聚焦的装置由一个或多个电动或静电聚焦透镜构成，所述电动或静电聚焦透镜被耦合到堆叠环离子导向件的第一电极 （SRIG），施加振荡（例如，射频）电压。 通过将离子转移装置的出口端大致配置到电动态或电动式离子转移装置中的期望位置，使这种堆叠的环形离子引导件的所需离子传递装置的有害场效应和/或重新定位问题最小化， 静态聚焦透镜。
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公开(公告)号：US20140014747A1
公开(公告)日：2014-01-16
申请号：US13550061
申请日：2012-07-16
IPC分类号： F23D11/32
CPC分类号： H01J49/10 , H01J49/165 , H01J49/167
摘要： An assembly for use in an electrospray ion source includes a capillary for guiding a flow of liquid generally containing analyte(s) of interest, which is to be electrosprayed into an ionization chamber, a first tube at least partially encasing the capillary such that a first conduit for guiding a first heatable gas is created proximate the capillary and a hollow member that has an internal evacuated space and is located at the outer circumference of the capillary such that heat transfer from the first heatable gas flowing proximate the capillary to the liquid in the capillary is impeded. The assembly provides a simple and lean/compact way of preventing excessive heat transfer to the liquid in the capillary of an electrospray ion source.
摘要翻译： 用于电喷雾离子源的组件包括毛细管，用于引导通常含有目标分析物的液体流，所述分析物将被电喷雾到电离室中，第一管至少部分地封装毛细管，使得第一 在毛细管附近产生用于引导第一可加热气体的导管，以及具有内部抽真空空间并位于毛细管外周的中空构件，使得来自第一可加热气体的热量传递到毛细管附近流到液体中 毛细管受阻。 该组件提供了一种简单且精益/紧凑的方法来防止电喷雾离子源的毛细管中的液体过度传热。
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10.发明授权Method and apparatus for an ion transfer tube and mass spectrometer system using same 有权用于离子转移管和使用其的质谱仪系统的方法和装置公开(公告)号：US08242440B2
公开(公告)日：2012-08-14
申请号：US12434540
申请日：2009-05-01
IPC分类号： H01J49/04
CPC分类号： H01J49/0404
摘要： A method for analyzing a sample comprising the steps of: generating ions from the sample within an ionization chamber at substantially atmospheric pressure; entraining the ions in a background gas; transferring the background gas and entrained ions to an evacuated chamber of a mass spectrometer system using a single-piece capillary having an inlet end and an outlet end, wherein a portion of the capillary adjacent to the outlet end comprises an inner diameter that is greater than an inner diameter of an adjoining portion of the capillary; and analyzing the ions using a mass analyzer of the mass spectrometer system.
摘要翻译： 一种用于分析样品的方法，包括以下步骤：在基本上大气压下在离子化室内从样品产生离子; 在背景气体中夹带离子; 将背景气体和夹带的离子转移到使用具有入口端和出口端的单件式毛细管的质谱仪系统的真空室中，其中与出口端相邻的毛细管的一部分包括大于 毛细管的邻接部分的内径; 并使用质谱仪系统的质量分析仪分析离子。
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