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公开(公告)号：US20080146598A1
公开(公告)日：2008-06-19
申请号：US12072070
申请日：2008-02-22
申请人： James A. Bianco
发明人： James A. Bianco
IPC分类号： A61K31/513 , A61K31/337 , A61P35/00
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/08 , A61K31/00 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/7072 , A61K33/24 , A61K41/0038 , A61K47/547 , A61K47/645 , A61K51/0497 , A61K2300/00
摘要： The present invention discloses combinations of drug conjugates with other therapeutic agents, including chemotherapy drugs. The invention also provides methods of using the combinations for the treatment of diseases associated with cell proliferation, such as tumors.
摘要翻译： 本发明公开了药物偶联物与其它治疗剂的组合，包括化疗药物。 本发明还提供了使用组合来治疗与细胞增殖相关的疾病如肿瘤的方法。
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2.发明授权Enantiomerically pure hydroxylated xanthine compounds to treat autoimmune diabetes 失效对映异构纯羟基化黄嘌呤化合物治疗自身免疫性糖尿病
公开(公告)号：US5739138A
公开(公告)日：1998-04-14
申请号：US457703
申请日：1995-06-01
申请人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
发明人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
IPC分类号： C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
CPC分类号： A61K31/522 , A61K31/519 , A61K31/52 , C07D473/10 , Y02P20/582 , Y10S514/814 , Y10S514/866 , Y10S514/921
摘要： There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
摘要翻译： 公开了化合物和药物组合物，其是在3,7-二取代的黄嘌呤的1-位取代的直链烷基（C5-8）的ω-1醇的分解的R或S（优选R）对映异构体。 本发明化合物有效地调节对外部或原位初级刺激的细胞反应，以及有效量的这些化合物的特定给药模式。
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公开(公告)号：US5621102A
公开(公告)日：1997-04-15
申请号：US456897
申请日：1995-06-01
申请人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
发明人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
IPC分类号： C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10 , C07D473/08 , C07D473/12
CPC分类号： A61K31/522 , A61K31/519 , A61K31/52 , C07D473/10 , Y02P20/582 , Y10S514/814 , Y10S514/866 , Y10S514/921
摘要： There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
摘要翻译： 公开了化合物和药物组合物，其是在3,7-二取代的黄嘌呤的1-位取代的直链烷基（C5-8）的ω-1醇的分解的R或S（优选R）对映异构体。 本发明化合物有效地调节对外部或原位初级刺激的细胞反应，以及有效量的这些化合物的特定给药模式。
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4.发明授权
公开(公告)号：US5652243A
公开(公告)日：1997-07-29
申请号：US343810
申请日：1994-11-22
申请人： James A. Bianco , Jack Singer
发明人： James A. Bianco , Jack Singer
IPC分类号： C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
CPC分类号： A61K31/522 , A61K31/519 , A61K31/52 , C07D473/10 , Y02P20/582 , Y10S514/814 , Y10S514/866 , Y10S514/921
摘要： There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
摘要翻译： 公开了化合物和药物组合物，其是在3,7-二取代的黄嘌呤的1-位取代的直链烷基（C5-8）的ω-1醇的分解的R或S（优选R）对映异构体。 本发明化合物有效地调节对外部或原位初级刺激的细胞反应，以及有效量的这些化合物的特定给药模式。
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公开(公告)号：US5580874A
公开(公告)日：1996-12-03
申请号：US457685
申请日：1995-06-01
申请人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
发明人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
IPC分类号： A61K31/52 , A61K31/522 , C07D473/10
CPC分类号： A61K31/52 , A61K31/522 , C07D473/10 , Y02P20/582
摘要： Them is disclosed compounds and pharmaceutical compositions that is R enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in treating the side effects of immunosuppressive agent and interleukin-2 therapy.
摘要翻译： 他们公开了化合物和药物组合物，其是在3,7-二取代黄嘌呤的1-位取代的直链烷基（C5-8）的ω-1醇的R对映异构体。 本发明化合物有效治疗免疫抑制剂和白细胞介素-2治疗的副作用。
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公开(公告)号：US5792772A
公开(公告)日：1998-08-11
申请号：US458957
申请日：1995-06-01
申请人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
发明人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
IPC分类号： C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
CPC分类号： A61K31/522 , A61K31/519 , A61K31/52 , C07D473/10 , Y02P20/582 , Y10S514/814 , Y10S514/866 , Y10S514/921
摘要： There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
摘要翻译： 公开了化合物和药物组合物，其是在3,7-二取代的黄嘌呤的1-位取代的直链烷基（C5-8）的ω-1醇的分解的R或S（优选R）对映异构体。 本发明化合物有效地调节对外部或原位初级刺激的细胞反应，以及有效量的这些化合物的特定给药模式。
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7.发明授权Treatment of diseases using enantiomerically pure hydroxylated xanthine compounds 失效使用对映体纯的羟基化黄嘌呤化合物治疗疾病
公开(公告)号：US5629315A
公开(公告)日：1997-05-13
申请号：US456900
申请日：1995-06-01
申请人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
发明人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
IPC分类号： C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
CPC分类号： A61K31/522 , A61K31/519 , A61K31/52 , C07D473/10 , Y02P20/582 , Y10S514/814 , Y10S514/866 , Y10S514/921
摘要： There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
摘要翻译： 公开了化合物和药物组合物，其是在3,7-二取代的黄嘌呤的1-位取代的直链烷基（C5-8）的ω-1醇的分解的R或S（优选R）对映异构体。 本发明化合物有效地调节对外部或原位初级刺激的细胞反应，以及有效量的这些化合物的特定给药模式。
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8.发明授权Enatiomerically pure hydroxylated xanthine compounds to treat inflammatory diseases 失效对羟基化黄嘌呤类化合物治疗炎性疾病
公开(公告)号：US5620984A
公开(公告)日：1997-04-15
申请号：US456898
申请日：1995-06-01
申请人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
发明人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
IPC分类号： C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
CPC分类号： A61K31/522 , A61K31/519 , A61K31/52 , C07D473/10 , Y02P20/582 , Y10S514/814 , Y10S514/866 , Y10S514/921
摘要： There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in treating inflammatory disease.
摘要翻译： 公开了化合物和药物组合物，其是在3,7-二取代的黄嘌呤的1-位取代的直链烷基（C5-8）的ω-1醇的分解的R或S（优选R）对映异构体。 本发明化合物有效治疗炎性疾病。
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9.发明授权Enantiomerically pure hydroxylated xanthine compounds to treat shock symptoms 失效对映异构纯羟基化黄嘌呤化合物治疗休克症状
公开(公告)号：US5612349A
公开(公告)日：1997-03-18
申请号：US457062
申请日：1995-06-01
申请人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
发明人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
IPC分类号： C07D473/06 , A61K20060101 , A61K31/44 , A61K31/519 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/06 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/10 , A61P25/20 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P39/02 , A61P43/00 , C07D473/04 , C07D473/10
CPC分类号： A61K31/522 , A61K31/519 , A61K31/52 , C07D473/10 , Y02P20/582 , Y10S514/814 , Y10S514/866 , Y10S514/921
摘要： There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in modulating cellular response to external or in situ primary stimuli, as well as to specific modes of administration of such compounds in effective amounts.
摘要翻译： 公开了化合物和药物组合物，其是在3,7-二取代的黄嘌呤的1-位取代的直链烷基（C5-8）的ω-1醇的分解的R或S（优选R）对映异构体。 本发明化合物有效地调节对外部或原位初级刺激的细胞反应，以及有效量的这些化合物的特定给药模式。
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10.发明授权
公开(公告)号：US5567704A
公开(公告)日：1996-10-22
申请号：US457683
申请日：1995-06-01
申请人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
发明人： James A. Bianco , Paul Woodson , David Porubek , Jack Singer
IPC分类号： A61K31/52 , A61K31/522 , C07D473/10
CPC分类号： A61K31/52 , A61K31/522 , C07D473/10 , Y02P20/582
摘要： There is disclosed compounds and pharmaceutical compositions that are a resolved R or S (preferably R) enantiomer of an .omega.-1 alcohol of a straight chain alkyl (C.sub.5-8) substituted at the 1-position of 3,7-disubstituted xanthine. The inventive compounds are effective in treating baldness.
摘要翻译： 公开了化合物和药物组合物，其是在3,7-二取代的黄嘌呤的1-位取代的直链烷基（C5-8）的ω-1醇的分解的R或S（优选R）对映异构体。 本发明化合物有效治疗秃发。
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