公开(公告)号：US07448267B2

公开(公告)日：2008-11-11

申请号：US11103090

申请日：2005-04-11

Applicant: Thomas D. Williams ,  Steve Haydu ,  Ronald Jan Hall ,  Steve Watson ,  Bill Shaffer ,  Neal Nehrenz ,  James Beebe

Inventor： Thomas D. Williams ,  Steve Haydu ,  Ronald Jan Hall ,  Steve Watson ,  Bill Shaffer ,  Neal Nehrenz ,  James Beebe

IPC: G01M1/16

CPC classification number: G01M1/06 ,  G01M1/045 ,  G01M1/225

Abstract: A machine and method for performing balancing measurements on a tire or tire/wheel assembly that includes a structure defining spaced apart tire centering and tire testing positions. A first conveyor moves a tire to a centering position where a shuttle assembly is operative to center the tire and, after it has been centered, engages the tire and effects the transfer of the tire from the centering station to a testing station. The shuttle assembly includes a pair of grippers that move towards and away from each other, in a lateral direction in order to engage the tire. The first conveyor permits movement of the tire in a lateral direction; whereas it substantially resists relative movement between the tire and conveyor in the longitudinal direction, i.e., the direction of movement of the conveyor. The shuttle assembly is mounted for movement in a longitudinal direction and includes a drive mechanism which allows the shuttle assembly to move relative to a tire in a longitudinal direction as the grippers engage the tire so that the shuttle assembly can align itself, in the longitudinal direction with respect to the tire. The frame structure of the machine includes three spaced apart support members providing a three point support arrangement for the machine. The machine also includes at least four legs which extend downwardly, but are spaced above a plane defined by the support members and inhibit tipping of the machine beyond predetermined limits. The testing station which includes a spindle assembly for rotating the tire also includes an elevator mechanism for lowering the tire on to the spindle and for raising the tire off the spindle. A lower marking mechanism forms part of the elevator and is operative to mark a predetermined location on the tire at the conclusion of a tire testing procedure. The spindle assembly includes a drive motor comprised of a drive motor housing and an armature. The armature is maintained in its operative position by a bearing arrangement associated with a shaft assembly forming part of the spindle assembly which eliminates the need for armature supporting bearings in the drive motor housing.

公开(公告)号：US20070287178A1

公开(公告)日：2007-12-13

申请号：US11449344

申请日：2006-06-08

Applicant: David James Beebe ,  Hongmei Yu ,  Caroline Alexander

Inventor： David James Beebe ,  Hongmei Yu ,  Caroline Alexander

IPC: C12N5/02

CPC classification number: C12N5/0062

Abstract: Co-cultures of heterogeneous cell populations in a diffusion-constrained microenvironment and methods for co-culturing are disclosed.

Abstract translation: 公开了扩散受限微环境中异源细胞群体的共培养和共培养方法。

公开(公告)号：US06915684B2

公开(公告)日：2005-07-12

申请号：US10417291

申请日：2003-04-16

Applicant: James Beebe ,  Barry Cargould ,  Richard Matuszny

Inventor： James Beebe ,  Barry Cargould ,  Richard Matuszny

IPC: G01M1/22 ,  G01M17/02 ,  E01C23/00

CPC classification number: G01M17/022 ,  G01M17/02

Abstract: A method and apparatus for testing tires in a repeatable manner. Testing steps are performed in a manner that minimizes impact on the tire characteristics being measured. In one aspect, tire rotation reversal is performed at a zero crossing of a first harmonic of radial load variation exerted on a load carriage by the tire. In another aspect, load carriage retraction is performed so that the tire is unloaded when the tire stops rotating.

Abstract translation: 一种以可重复的方式测试轮胎的方法和装置。 测试步骤以最小化对所测量的轮胎特性的影响的方式进行。 在一个方面，在通过轮胎施加在负载滑架上的径向载荷变化的一次谐波的零交叉处进行轮胎旋转反转。 在另一方面，执行负载滑架收回，使得轮胎在轮胎停止转动时卸载。

公开(公告)号：US20150087006A1

公开(公告)日：2015-03-26

申请号：US14491701

申请日：2014-09-19

Applicant: Chorom Pak ,  Edmond Wai Keung Young ,  Natalie Callander ,  David James Beebe ,  Shigeki Miyamoto

Inventor： Chorom Pak ,  Edmond Wai Keung Young ,  Natalie Callander ,  David James Beebe ,  Shigeki Miyamoto

IPC: G01N33/50

CPC classification number: G01N33/5008 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0472 ,  C12M23/16 ,  G01N33/5044 ,  G01N33/54366 ,  G01N33/57426 ,  G01N2500/04

Abstract: The invention relates to systems and methods for studying patient cancer samples in cis-co-culture. For example, the invention provide systems and methods for testing therapeutic agents in vitro in an environment that simulates an in vivo environment to identify agents that are therapeutically effective for the patient.

Abstract translation: 本发明涉及用于研究顺式共培养中的患者癌症样品的系统和方法。 例如，本发明提供了在模拟体内环境以鉴定对患者有治疗效力的药剂的环境中体外测试治疗剂的系统和方法。

公开(公告)号：US08124410B2

公开(公告)日：2012-02-28

申请号：US11449344

申请日：2006-06-08

Applicant: David James Beebe ,  Hongmei Yu ,  Caroline Alexander

Inventor： David James Beebe ,  Hongmei Yu ,  Caroline Alexander

IPC: C12N5/02

CPC classification number: C12N5/0062

Abstract: Co-cultures of heterogeneous cell populations in a diffusion-constrained microenvironment and methods for co-culturing are disclosed.

Abstract translation: 公开了扩散受限微环境中异源细胞群体的共培养和共培养方法。

公开(公告)号：US20060016258A1

公开(公告)日：2006-01-26

申请号：US11103090

申请日：2005-04-11

Applicant: Thomas Williams ,  Steve Haydu ,  Ronald Hall ,  Steve Watson ,  Bill Shaffer ,  Neal Nehrenz ,  James Beebe

Inventor： Thomas Williams ,  Steve Haydu ,  Ronald Hall ,  Steve Watson ,  Bill Shaffer ,  Neal Nehrenz ,  James Beebe

IPC: G01M1/06

CPC classification number: G01M1/06 ,  G01M1/045 ,  G01M1/225

Abstract: A machine and method for performing balancing measurements on a tire or tire/wheel assembly that includes a structure defining spaced apart tire centering and tire testing positions. A first conveyor moves a tire to a centering position where a shuttle assembly is operative to center the tire and, after it has been centered, engages the tire and effects the transfer of the tire from the centering station to a testing station. The shuttle assembly includes a pair of grippers that move towards and away from each other, in a lateral direction in order to engage the tire. The first conveyor permits movement of the tire in a lateral direction; whereas it substantially resists relative movement between the tire and conveyor in the longitudinal direction, i.e., the direction of movement of the conveyor. The shuttle assembly is mounted for movement in a longitudinal direction and includes a drive mechanism which allows the shuttle assembly to move relative to a tire in a longitudinal direction as the grippers engage the tire so that the shuttle assembly can align itself, in the longitudinal direction with respect to the tire. The frame structure of the machine includes three spaced apart support members providing a three point support arrangement for the machine. The machine also includes at least four legs which extend downwardly, but are spaced above a plane defined by the support members and inhibit tipping of the machine beyond predetermined limits. The testing station which includes a spindle assembly for rotating the tire also includes an elevator mechanism for lowering the tire on to the spindle and for raising the tire off the spindle. A lower marking mechanism forms part of the elevator and is operative to mark a predetermined location on the tire at the conclusion of a tire testing procedure. The spindle assembly includes a drive motor comprised of a drive motor housing and an armature. The armature is maintained in its operative position by a bearing arrangement associated with a shaft assembly forming part of the spindle assembly which eliminates the need for armature supporting bearings in the drive motor housing.